Hemoglobin-to-red blood cell distribution width ratio as a protective factor against coronary artery disease: a cross-sectional analysis of NHANES (2011-2018)

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Background Coronary artery disease (CAD) is the leading cause of death worldwide, and inflammation a significant factor in its development. While hemoglobin-to-red blood cell distribution width ratio (HRR), an indicator inflammation, has been linked to various diseases, association with CAD not well established. Methods We conducted analysis using data from National Health Nutrition Examination Survey (NHANES) spanning 2011 2018. After excluding participants due age, missing data, potential confounding factors, 6,881 individuals were included our study. was identified through self-reported questionnaires, HRR determined laboratory measurements. controlled for factors such as hypertension, waist circumference, systolic pressure, fasting plasma glucose, others logistic regression explore relationship between CAD. Results found that higher levels associated lower risk In fully adjusted model, odds ratios second, third, fourth quartiles 0.38, 0.42, 0.51, respectively, compared first quartile (P < 0.001). An increase by one unit 49% decrease likelihood Furthermore, linear models indicated 74% reduction each one-unit = 0.0002). There notable threshold at 1.02; beyond this point, 91% odds. This suggests above 1.02, strategies body water content reduce viscosity could potentially their developing Conclusion Our study revealed inverse risk, indicating may serve protective against

Language: Английский

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Systemic Immune-Inflammatory Index as a Prognostic Biomarker in Patients with Heart Failure: A Comprehensive Analysis

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Objective This study aimed to assess the prognostic significance of Systemic Immune-Inflammatory Index (SII) in chronic heart failure (CHF) patients and evaluate its potential as a predictive biomarker. Methods A retrospective analysis was conducted on 2748 CHF from First Affiliated Hospital Xinjiang Medical University 2012 2022. The primary outcome all-cause mortality (ACM), with readmission rates secondary endpoints. An optimal SII cutoff value 916.68 determined for predicting ACM. Results Elevated levels were significantly correlated an increased risk ACM across all left ventricular ejection fraction (LVEF) categories. high group had 43.8% compared low group. Conclusion is significant biomarker CHF, independent traditional factors, highlighting importance stratification clinical decision-making, necessitating further investigation prospective studies.

Language: Английский

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Association between dietary oxidative balance scores and myocardial infarction in diabetic patients: insights from NHANES 1999–2018

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Myocardial infarction (MI) poses a serious health threat to diabetic patients, who are particularly vulnerable due heightened oxidative stress. The dietary balance score (DOBS) quantifies the overall profile of diet and may reflect diet-related cardiovascular risk. This study aimed evaluate association between DOBS risk MI among individuals using nationally representative U.S. We analyzed data from 5,002 participants in NHANES 1999-2018 cycles. was calculated based on 16 pro- antioxidant nutrients two 24-hour recalls. Logistic regression models 1:1 propensity matching (PSM) were employed assess self-reported history MI, adjusting for demographic, clinical, lifestyle covariates. Restricted cubic spline (RCS) used potential nonlinear relationships. A one-point increase associated with 3% lower odds both unadjusted fully adjusted (adjusted OR = 0.97, 95% CI: 0.95-0.99). Participants highest tertile had 38% compared lowest (OR 0.62, 0.43-0.87), this remained consistent matched cohort 0.72, 0.48-0.88). While formal tests nonlinearity not significant, RCS curves suggested threshold effect diminishing benefits at higher levels. Subgroup sensitivity analyses confirmed robustness findings. Higher is likelihood patients. These findings highlight value antioxidant-rich patterns assessment. However, given geographic cultural variability diet, further validation needed diverse populations prospective settings.

Language: Английский

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Association between oxidative balance score and gallstone disease: a population-based study from NHANES

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Background Oxidative stress has been reported to participant in the pathogenesis of gallstones. balance score (OBS) represents pro-oxidant and antioxidant exposures diet lifestyle, closely associated with multiple metabolic disorders. However, relationship between OBS gallstones remains unclear. Methods This study analyzed cross-sectional data from National Health Nutrition Examination Survey (NHANES) 2017–2020. was calculated based on 24-h recall interviews or questionnaires. We used weighted logistic regression, restricted cubic splines (RCS), quantile sum (WQS) regression Bayesian kernel machine (BKMR) model identify Subgroup analysis sensitivity were explore potential heterogeneity stability results. Mediation performed assess mediating effects serum lipid association Results A total 7,618 participants finally included this study. Weighted logistics showed that risk (OR = 0.98, p 0.03), particularly individuals who under 60 years old, Hispanic, educated below high school, non-smokers, had hypertension malignancy. Dietary lifestyle independently contribute protection against RCS indicated a non-linear ( 0.03). WQS BKMR identified BMI, vitamin E, B6, magnesium carotene played relatively important role among 20 components. TG HDL as mediators Conclusion Higher increased oxidative are positively reduction gallstone risk. findings provide valuable insights for surveillance interventions targeting antioxidant-rich disease.

Language: Английский

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Associations between oxidative balance scores and heart failure among americans: NHANES (2007–2018)

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 23, 2025

The relationship between oxidative balance score (OBS) and heart failure (HF) is controversial. OBS was used to assess systemic stress status, with higher scores implying exposure more antioxidants. This study aimed explore whether associated in US adults. A cross-sectional investigation carried out using information from the National Health Nutrition Examination Survey 2007–2018. linear link HF adults aged ≥ 45 years investigated multivariate regression models. Interaction tests subgroup analysis were also conducted. prevalence of 3.84%. There a significant negative (OR: 0.96 ,95%CI: 0.95–0.98, P < 0.0001) HF. In fully adjusted model, compared lowest quartile OBS, subjects highest had 45% lower likelihood developing 0.55, 95% CI: 0.41–0.74, p 0.0001). stratified analysis, showed no obvious correlation. strongly negatively failure. findings underline significance adhering an antioxidant diet lifestyle, which helps prevent

Language: Английский

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Associations Between Folate Intake, Serum Folate, and Stroke Risk: The Mediating Role of Dietary Inflammatory Index from NHANES 2007-2018

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108318 - 108318

Published: April 1, 2025

Language: Английский

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The effect of dietary oxidation balance scores and volatile organic compounds exposures on inflammation

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117163 - 117163

Published: Oct. 12, 2024

Language: Английский

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Association between oxidative balance score and cardiovascular diseases: mediating analysis of methylmalonic acid based on the NHANES database

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 11, 2024

To explore the association between oxidative balance score (OBS) and cardiovascular diseases (CVD) in patients with hypertension, further clarify mediating role of methylmalonic acid (MMA) relationship OBS CVD risk.

Language: Английский

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Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

Oxidative stress has an important role in type 2 diabetes (T2D). balance score (OBS) is emerging assessment of dietary and lifestyle oxidative balance. We aimed to explore the association OBS with cardiovascular disease (CVD) all-cause CVD mortality T2D population through NHANES 1999-2018.

Language: Английский

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Effects of the Interaction Between Oxidative Balance Score and Polygenic Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean Adults

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1556 - 1556

Published: Dec. 18, 2024

Oxidative stress is implicated in insulin resistance, obesity, and metabolic syndromes (MetSs). However, the interplay between oxidative genetic predisposition during development of MetS remains unclear. In this study, we aimed to investigate effects interaction balance score (OBS) polygenic risk (PRS) on incidence middle-aged Korean adults. We analyzed data from 25,879 participants aged ≥40 years Health Examinees Cohort Genome Epidemiology Study. The OBS was calculated using 11 antioxidant five pro-oxidant factors. A genome-wide association study clumping analysis identified 16 independent single-nucleotide polymorphisms associated with that were used calculate individual PRSs. Multivariable Cox proportional hazard models adjusted for confounding variables assess impact PRS MetS. During a mean follow-up period 4.3 years, recorded 3153 cases both men women, group lowest high had 1.50-fold (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.07–2.11) 1.89-fold (HR 1.89, CI 1.40–2.56) higher incidence, respectively, compared those highest low PRS. Among women PRS, HRs decreased significantly across quintiles 1 through 5 (p trend = 0.009). These findings suggest managing may be particularly crucial individuals

Language: Английский

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