Association between oxidative balance score and lung function and FeNO and mortality in the US population

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

The Oxidative Balance Score (OBS) is a new indicator of overall antioxidant/oxidant balance that provides comprehensive picture the body's oxidative stress status, with higher OBS indicating greater antioxidant exposure. A limited number studies have examined association between and lung function FeNO, we aimed to investigate possible relationship FeNO. Data utilized in this study were sourced from 2007-2012 NHANES. Multivariable logistic regression was employed OBS/lifestyle (lifestyle antioxidants such as physical activity, etc., lifestyle pro-oxidants alcohol, smoking, etc.)/dietary (dietary fiber, β-carotene, riboflavin, dietary pro-oxidants, total fat, etc.) FEV1, FVC, PEF, FEF 25%- 75%, well obstructive ventilation dysfunction. dose-response FVC PEF explored using RCS analysis. Subgroup analysis interaction tests also conducted. We used multivariable Cox modeling explore OBS/dietary all-cause respiratory-related mortality. 8,568 participants enrolled. statistically significant observed levels. There no statistical OBS, FeNO revealed linear both FEV1 Notably, positive correlation more male participants. Conversely, levels influenced by gender BMI. effects on parameters independent whether had restrictive ventilatory dysfunction or dysfunction.In addition, demonstrated inverse associations mortality, whereas relationships these scores only exhibited In study, positively correlated (FEV1, PEF) U.S. adults. Exploring can enhance our understanding how homeostasis influences changes. This could provide valuable interventions for decline. found associated lower Adopting healthy consuming an antioxidant-rich diet may significantly improve prognosis patients reducing stress-related damage.

Language: Английский

The negative linear relationship between oxidative balance scores and constipation: a cross-sectional study from NHANES 2005–2010

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 15, 2024

Background This study aimed to investigate the relationship between oxidation balance score (OBS) and constipation. Methods All data was collected from 2005–2010 cycles of National health nutrition examination survey (NHANES) database. The OBS constipation analyzed by logistic regression, restricted cubic spline. Trend analysis used explore whether there is a linear quartiles constipation, while interaction conducted determine other factors influence Subgroup examine two in different subgroups. three machine learning algorithms including Xgboost, Randomforest, AdaBoost analyze important component Results A total 8,074 participants were involved. We found that negative also existed after adjusting for all possible confounders. trend test showed higher OBS, lower likelihood developing ( P trend<0.05). marital status diabetes interact with on receiver operating characteristic indicated had good prediction efficiency especially without married or living partner. body mass index magnesium components related Conclusion Oxidation negatively associated occurrence adults. Moreover,

Language: Английский