Principles of Nutrition in Patients with Nonalcoholic Fatty Liver Disease DOI Creative Commons
Narges Mobasheri, Leila Ghahremani, Mahin Nazari

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

This chapter will comprehensively address the nutritional principles essential for managing nonalcoholic fatty liver disease (NAFLD). It explore critical role of diet in prevention and treatment NAFLD, providing evidence-based dietary recommendations to improve health overall well-being patients. Key topics include importance balanced macronutrient intake, specific nutrients food groups (e.g., antioxidants, fiber, healthy fats), impact patterns such as Mediterranean Dietary Approaches Stop Hypertension (DASH) on fat reduction inflammation. Additionally, discuss significance weight management, outlining standard amount loss beneficial NAFLD Practical guidelines how implement these changes, overcome common barriers, maintain long-term adherence be provided. aims equip healthcare professionals patients with knowledge tools necessary effectively manage through diet, ultimately improving patient outcomes quality life.

Language: Английский

The Effect of Flavonoids and Topiramate on Glucose Carbon Metabolism in a HepG2 Steatosis Cell Culture Model: A Stable Isotope Study DOI Open Access
Li Ma, Qing‐Yi Lu,

Shu Lim

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 564 - 564

Published: Jan. 31, 2025

Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied weight loss but need investigation into their effects on metabolism. This study’s aim was to examine the of flavonoids or glucose carbon flux in a cell culture model steatosis. Methods: Steatosis induced HepG2 cells through exposure oleic acid (OA, 0.5 mml/L) conjugated bovine serum albumin (2:1). Additionally, 50% U13C-glucose supplied medium as stable isotope tracer. Cells were treated with DMSO, 10 μM naringenin, morin, silibinin, (44 μM) 72 h. A non-steatotic, untreated control included. Cell extracts analyzed by gas chromatography/mass spectrometry mass isotopomer distribution analysis glycogen synthesis, de novo fatty tricarboxylic (TCA) cycle activity, ribose synthesis. Groups compared ANOVA Tukey’s pair-wise testing. Results: Compared controls, OA-exposed exhibited increased lipid accumulation ORO staining (1.6-fold), enhanced palmitate reduced pyruvate carboxylase/pyruvate dehydrogenase (PC/PDH) ratio, Treatment silibinin ameliorated (1.3-fold) mitigated enhancement Morin-treated synthesis suppressed Conclusions: Potential mechanisms may include suppression relative decrease PDH pathway. Further studies needed potential utility MASLD based specific effects.

Language: Английский

Citations

1
Metabolite Signatures and Their Mediation Effects on the Relationship Between Mediterranean Diet Adherence and MASLD Progression DOI Creative Commons
Kai Wang, Shijian Xiang,

Qiangsheng He

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Background Mediterranean Diet (MED) is recommended for managing patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). However, the potential metabolic changes involved in this relationship remain unclear. This study aims to investigate how biomarkers mediate association between MED adherence and liver-related events (LRE) mortality MASLD.Methods We performed a prospective analysis using UK Biobank data, including 47,429 MASLD participants free of LRE at baseline. was assessed as alternate (aMED) score through validated questionnaire covering 206 foods 32 beverages. were measured high-throughput nucleic magnetic resonance (NMR) spectroscopy. Cox regression restricted cubic splines aMED, its components, risk mortality. Mediation evaluated role metabolites progression.Results Over median follow-up 13.3 years, 296 cases 3,616 deaths occurred. Higher aMED scores (6–9) associated lower risks (HR: 0.553, 95% CI: 0.351–0.874) 0.854, 0.762–0.956) compared lowest (0–3). Linear dose-response relationships observed both incidence (Pnonlinear = 0.91) 0.07). Certain vegetables legumes, reduced LRE, while vegetables, nuts, fish, MUFA:SFA ratio, moderate alcohol intake linked risk. Of 143 metabolites, 46 significantly aMED. Positive associations included very large HDL particles (n 3), unsaturated fatty acids 8), albumin, acetate, negative found VLDL 11), small middle 13), saturated 2), Apo-AI, creatinine. Five aMED-related lipid negatively five positively revealed that omega-3 acids, total acid albumin accounted 7.9%, 11.9%, 2.6% reduction 19.4%, 23.1%, 4.7% mitigation mortality, respectively.Conclusions Adherence patients. such may mitigate progression.

Language: Английский

Citations

0
Dragon Fruit Peel (Hylocereus undatus) Modulates Hepatic Lipid Metabolism and Inflammation in a Rat Model of High-Fat, High-Fructose-Induced Metabolic Dysfunction DOI Creative Commons

Siriwan Chumroenvidhayakul,

Thavaree Thilavech, Mahinda Y. Abeywardena

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 319 - 319

Published: March 6, 2025

Metabolic dysfunction and hepatic abnormalities, such as those associated with high-fat, high-fructose (HFHFr) diets, are major contributors to obesity-related health issues. The growing interest in sustainable dietary interventions has highlighted the potential of plant-based byproducts. Dragon fruit (Hylocereus undatus) peel waste, rich bioactive compounds fibers, phenolics, betacyanins, represents a promising functional ingredient for managing these disorders. This study investigated effects dragon powder (DFP) on metabolic abnormalities induced by HFHFr diet rats. Over 12 weeks, rats were fed standard AIN-93M (control or C), C 5% (w/w) DFP (C + DFP), diet, (HFHFr DFP). supplementation significantly reduced HFHFr-induced body weight gain, visceral adiposity, insulin resistance, dyslipidemia while also lowering systolic blood pressure systemic oxidative stress markers. In liver, attenuated fat accumulation lipid peroxidation, glycogen storage modulated expression metabolism inflammatory genes. These findings suggest that may serve supplement preventing disorders liver excessive fructose consumption.

Language: Английский

Citations

0
Early childhood adiposity, lifestyle and gut microbiome are linked to steatotic liver disease development in adolescents DOI
Chenxi Cai, Zhengxiao Zhang, Gigliola Alberti

et al.

International Journal of Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD DOI Open Access
Giovanna Mercurio, Antonia Giacco,

Nicla Scopigno

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1214 - 1214

Published: March 30, 2025

Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern that closely linked to metabolic syndrome, yet no approved pharmacological treatment exists. The Mediterranean diet (MD) emerged as first-line dietary intervention for NAFLD, offering and hepatoprotective benefits. Now conceptualized complex chemical matrix rich in bioactive compounds, the MD exerts antioxidant anti-inflammatory effects, improving insulin sensitivity lipid metabolism. Mitochondria play central role NAFLD pathophysiology, influencing energy metabolism, oxidative stress, homeostasis. Emerging evidence suggests MD's compounds enhance mitochondrial function by modulating phosphorylation, biogenesis, mitophagy. However, most research has focused on individual rather than whole, leaving gaps understanding its collective impact pattern. This narrative review explores how influence highlighting key pathways such substrate control, dynamics, efficiency. A literature search was conducted identify relevant studies MD, mitochondria, NAFLD. While promising, our remains incomplete, particularly when current knowledge limited lack of mechanistic comprehensive holistic impact. Future integrating cutting-edge experimental approaches needed elucidate intricate diet-mitochondria interactions. deeper influences essential developing precision-targeted nutritional strategies can effectively prevent manage disease.

Language: Английский

Citations

0
LAdherence to the Dietary Approaches to Stop Hypertension Diet was Associated with the Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Observational Studies DOI

Shokouh Momeni,

Fatemeh Hajizadeh‐Sharafabad, Mohammad Reza Pashaei

et al.

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Mediterranean diet for the management of metabolic dysfunction‐associated steatotic liver disease in non‐Mediterranean, Western countries: What's known and what's needed? DOI Creative Commons
Ayesha Sualeheen, Sze‐Yen Tan, Ekavi N. Georgousopoulou

et al.

Nutrition Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common worldwide, affecting 30% of population in Western countries. MASLD considered hepatic manifestation metabolic syndrome, pathophysiologically underpinned by insulin resistance and frequently co‐exists with hypertension, central obesity dyslipidaemia. Currently, safe effective pharmacotherapies for are limited, making weight loss lifestyle changes mainstay therapy. A Mediterranean diet (MedDiet) has emerged as an dietary pattern preventing managing MASLD, but studies have been conducted countries, necessitating further investigation into its benefits populations. Additionally, effect holistic multimodal interventions, including physical activity combined MedDiet, not well established. Finally, MASLD's widespread prevalence rapid growth require improved accessibility to interventions. Digital health delivery platforms, designed remote access, could be a promising approach providing timely support individuals MASLD. This narrative review summarises current evidence related effects MedDiet Western, multicultural populations includes detailed description composition, prescription adherence interventions terms how they applied. The role or exercise prescribed combination will also reviewed. recommendations design inform future randomised controlled trials facilitate optimal management outlined.

Language: Английский

Citations

2
Principles of Nutrition in Patients with Nonalcoholic Fatty Liver Disease DOI Creative Commons
Narges Mobasheri, Leila Ghahremani, Mahin Nazari

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

This chapter will comprehensively address the nutritional principles essential for managing nonalcoholic fatty liver disease (NAFLD). It explore critical role of diet in prevention and treatment NAFLD, providing evidence-based dietary recommendations to improve health overall well-being patients. Key topics include importance balanced macronutrient intake, specific nutrients food groups (e.g., antioxidants, fiber, healthy fats), impact patterns such as Mediterranean Dietary Approaches Stop Hypertension (DASH) on fat reduction inflammation. Additionally, discuss significance weight management, outlining standard amount loss beneficial NAFLD Practical guidelines how implement these changes, overcome common barriers, maintain long-term adherence be provided. aims equip healthcare professionals patients with knowledge tools necessary effectively manage through diet, ultimately improving patient outcomes quality life.

Language: Английский

Citations

0