Impact of healthy lifestyles on the risk of metabolic dysfunction‐associated steatotic liver disease among adults with comorbid hypertension and diabetes: Novel insight from a largely middle‐aged and elderly cohort in South China DOI
Jun‐Yan Xi, Yijing Wang, Xiaoheng Li

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

The association between lifestyle and metabolic dysfunction-associated steatotic liver disease (MASLD) has been well documented. However, evidence is still limited from vulnerable populations, especially middle-aged elderly adults with comorbid hypertension diabetes, who are at higher risk of developing MASLD than the general population. We aimed to examine potential causal links a healthy in this A total 41,964 participants diabetes were included longitudinal cohort 2010 2023. Weighted scores for evaluated by exercise frequency, alcohol consumption, smoking status salt intake. Marginal structural models used estimate single lifestyle-MASLD associations, which further stratified quartile ranges weighted scores. mean follow-up period 5.2 years (217 972 person-years) revealed that 21 697 developed MASLD. hazard ratio (HR) daily exercise, never consuming alcohol, low intake was 0.617 (95% confidence interval: 0.365 ~ 1.042), 0.237 (0.093 0.603), 0.153 (0.097 0.240) 0.945 (0.919 0.971), respectively. Compared below 25th percentile, HR 0.952 (0.902 1.005), 0.747 (0.694 0.803) 0.097 (0.065 0.144) 25th, 50th 75th percentiles, In population, abstinence low-salt diet may reduce MASLD, most stringent combination lifestyles could over 90%.

Language: Английский

Cigarette Smoke Contributes to the Progression of MASLD: From the Molecular Mechanisms to Therapy DOI Creative Commons
Jihao Xu, Yifan Li,

Zhaolan Feng

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 221 - 221

Published: Feb. 4, 2025

Cigarette smoke (CS), an intricate blend comprising over 4000 compounds, induces abnormal cellular reactions that harm multiple tissues. Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic (CLD), encompassing non-alcoholic (NAFL), steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Recently, the term NAFLD has been changed to metabolic dysfunction-associated steatotic (MASLD), NASH renamed (MASH). A multitude of experiments have confirmed association between CS incidence progression MASLD. However, specific signaling pathways involved need be updated with new scientific discoveries. exposure can disrupt lipid metabolism, induce inflammation apoptosis, stimulate fibrosis through promote Currently, there no officially approved efficacious pharmaceutical intervention in clinical practice. Therefore, lifestyle modifications emerged as primary therapeutic approach for managing Smoking cessation application series natural ingredients shown ameliorate pathological changes induced by CS, potentially serving effective decelerating MASLD development. This article aims elucidate which smoking promotes MASLD, while summarizing reversal factors identified recent studies, thereby offering novel insights future research on treatment

Language: Английский

Citations

2
Impact of healthy lifestyles on the risk of metabolic dysfunction‐associated steatotic liver disease among adults with comorbid hypertension and diabetes: Novel insight from a largely middle‐aged and elderly cohort in South China DOI
Jun‐Yan Xi, Yijing Wang, Xiaoheng Li

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

The association between lifestyle and metabolic dysfunction-associated steatotic liver disease (MASLD) has been well documented. However, evidence is still limited from vulnerable populations, especially middle-aged elderly adults with comorbid hypertension diabetes, who are at higher risk of developing MASLD than the general population. We aimed to examine potential causal links a healthy in this A total 41,964 participants diabetes were included longitudinal cohort 2010 2023. Weighted scores for evaluated by exercise frequency, alcohol consumption, smoking status salt intake. Marginal structural models used estimate single lifestyle-MASLD associations, which further stratified quartile ranges weighted scores. mean follow-up period 5.2 years (217 972 person-years) revealed that 21 697 developed MASLD. hazard ratio (HR) daily exercise, never consuming alcohol, low intake was 0.617 (95% confidence interval: 0.365 ~ 1.042), 0.237 (0.093 0.603), 0.153 (0.097 0.240) 0.945 (0.919 0.971), respectively. Compared below 25th percentile, HR 0.952 (0.902 1.005), 0.747 (0.694 0.803) 0.097 (0.065 0.144) 25th, 50th 75th percentiles, In population, abstinence low-salt diet may reduce MASLD, most stringent combination lifestyles could over 90%.

Language: Английский

Citations

0