Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, other death mechanisms. It implicated the advancement multiple diseases across body. Researchers currently know that osteosarcoma, osteoporosis, orthopedic disorders are caused NRF2, GPX4, star proteins. effective relief osteoarthritis symptoms from deterioration been confirmed clinical treatment with inhibitors. At same time, it should be reminded mechanisms involved regulate not understood. In this manuscript, we present discovery ferroptosis, role variety diseases. We expect manuscript can provide new perspective on diagnosis related

Language: Английский