High-Intensity Interval Training Reduces Liver Enzyme Levels and Improves MASLD-Related Biomarkers in Overweight/Obese Girls

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 164 - 164

Published: Jan. 1, 2025

Background/Objectives: Despite the abundant body of evidence linking high-intensity interval training (HIIT) to cardiometabolic markers, little is known about how HIIT affects liver enzymes, particularly in obese adolescents. This study aimed investigate effects on metabolic dysfunction-associated steatotic disease (MASLD)-related biomarkers overweight/obese adolescent girls. Methods: Thirty-three girls (age, 17.0 ± 1.15 yr.; mass index, 33.3 4.77 kg/m2) were randomly assigned (n = 17) or control 16) groups. The group participated a nine-week program (three times weekly) without caloric restriction. Maximal aerobic speed, composition indexes, blood pressure, MASLD-related [liver enzymes (alanine aminotransferase (ALT) and aspartate (AST)), plasma lipids, uric acid, platelet count, homeostasis model assessment index for insulin-resistance (HOMA-IR)] examined at baseline after intervention. Results: Significant “time × group” interactions found systolic maximal ALT AST, glucose, HOMA-IR. resulted an increase speed (p 0.035) decrease lipids < 0.01), pressure 0.011), 0.013), AST 0.012), HOMA-IR but no significant changes acid count. None these markers changed group. Conclusions: improvement biomarkers. could be effective exercise therapy prevent reverse MASLD adolescents with obesity.

Language: Английский

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Exploring the association between dietary indices and metabolic dysfunction-associated steatotic liver disease: Mediation analysis and evidence from NHANES

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321251 - e0321251

Published: April 17, 2025

Background The association between dietary indices and metabolic dysfunction-associated steatotic liver disease (MASLD) has shown inconsistent results in previous studies. Additionally, the potential mediating variables linking quality to MASLD have not been adequately explored. Methods We analyzed data from 6,369 participants National Health Nutrition Examination Survey (NHANES) 2007–2018. Three indices—Healthy Eating Index (HEI), Energy-adjusted Dietary Inflammatory (EDII), Composite Antioxidant (CDAI)—were evaluated for their associations with using logistic regression models adjusted a comprehensive range of covariates. Mediation analysis was performed evaluate roles mediators four domains: insulin resistance (homeostatic model assessment resistance, HOMA-IR; score METS-IR), systemic inflammation (systemic inflammatory response index, SIRI; immune-inflammation SII), obesity or visceral fat distribution (a body shape ABSI; roundness BRI), oxidative stress (Gamma-Glutamyltransferase, GGT; Bilirubin; Uric Acid). Results After adjusting all covariates, only HEI showed consistent inverse MASLD, while EDII CDAI no significant associations. identified METS-IR, HOMA-IR, BRI, ABSI as relationship mediation proportion accounting 47.16%, 48.84%, 52.69%, 13.84%, respectively. Conclusion Higher is associated reduced risk MASLD. findings suggest that partially mediate providing insights into mechanisms diet health.

Language: Английский

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Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

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CSE/H2S Signaling Pathways in Enhancing Muscle Function and Insulin Sensitivity During Exercise

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1741 - 1741

Published: Feb. 18, 2025

Exercise plays a crucial role in maintaining metabolic health, enhancing muscle function, and improving insulin sensitivity, thereby preventing diseases such as type 2 diabetes. Emerging evidence highlights the significance of cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) signaling pathway pivotal regulator molecular physiological adaptations induced by exercise. This review comprehensively examines biosynthesis metabolism H2S, its distribution different tissues, mechanisms which CSE/H2S influences contraction, repair, protein synthesis. Additionally, it explores how modulates pathways, glucose uptake, lipid metabolism, sensitivity. The potential H2S donors exercise supplements is also discussed, highlighting their ability to improve performance health. Current research advancements, including application multi-omics approaches, are reviewed provide deeper understanding complex networks involved. Furthermore, challenges future directions addressed, emphasizing need for further mechanistic studies clinical applications. underscores therapeutic targeting optimize benefits

Language: Английский

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The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1257 - 1257

Published: April 3, 2025

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, optimal approach remains uncertain. Objectives: This systematic review aims to investigate impact model patterns on metabolic outcomes in patients evaluate their effects individuals coexisting conditions, such as obesity, syndrome, type 2 diabetes mellitus (T2DM). Methods: To conduct review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) adult population, published between January 2019 September 2024, following PRISMA principles. The quality included RCTs was assessed qualitatively based study characteristics. Results: main findings this demonstrated that use interventions Mediterranean diet (MED) intermittent fasting (IF) approaches, alternative-day (ADF) time-restricted feeding regimens (TRF) may have potential reducing body weight, BMI, waist circumference, additional benefits improving glycemic control inflammation. hepatic functions, although limited, be reduced enzyme activity stiffness. Additionally, lacto-ovo-vegetarian (LOV-D) Dietary Approaches Stop Hypertension (DASH) offer benefits, including blood pressure management. Conclusions: suggests MED IF-based strategies reduce BW, improve control, lower inflammation, function. Further long-term studies are needed confirm these underlying mechanisms, which will allow optimization protocols ensure safety MASLD.

Language: Английский

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The Relationship Between Gut Health and Sports Performance

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 307 - 342

Published: Feb. 28, 2025

The gut-brain-muscle axis is a dynamic network illustrating the interaction between gut health, cognitive function, and physical performance. This chapter delves into critical role of health in influencing sports performance, highlighting interplay microbiota, neurotransmitters, metabolic pathways. By fostering optimal through diet, exercise, stress management, athletes can enhance nutrient absorption, energy metabolism, immune function. Furthermore, impacts mental resilience recovery, underscoring its significance for peak athletic Emphasizing personalized nutrition training strategies, work provides actionable insights optimizing performance well-being contexts.

Language: Английский

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The association between lifelines diet score and metabolic associated fatty liver disease: a case–control study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 15, 2025

Introduction Adherence to a healthy dietary pattern is fundamental recommendation for the prevention of Metabolic Associated Fatty Liver Disease (MAFLD); however, conclusive evidence regarding optimal remains elusive. Objectives The Lifelines Diet Score (LLDS) novel, evidence-based scoring system designed evaluate diet quality. However, despite extensive research on patterns and liver health, specific relationship between LLDS MAFLD underexplored. This study aims investigate association MAFLD, providing insights into how adherence, as measured by LLDS, may influence risk prevalence MAFLD. Methods case–control enrolled 215 individuals who had recently been diagnosed with 430 controls at King Khalid University Hospital. All participants were aged 20 60 years, data collection occurring from February 2023 January 2025. intake was assessed through utilization validated semi-quantitative food frequency questionnaire, which comprised total 168 distinct items. Logistic regression used estimate Results Out 645 participants, newly patients analyzed. After stratifying based tertiles, those in highest group 78% lower odds than lowest tertile (odds ratio (OR): 0.22; 95% Confidence interval (CI): 0.12–0.36, p trend &lt;0.001). remained robust even after adjustment major confounders. These findings highlight novel assessment health research. Conclusion Our strengthens that adherence (as LLDS) associated risk, accounting further integrating genetic molecular needed refine personalized recommendations prevention.

Language: Английский

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Diet quality and physical activity affect metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and etiology-associated steatohepatitis, and compensated advanced chronic liver disease among United States adults: NHANES 2017–2020

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 8, 2025

Clinical data on the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and dysfunction etiology-associated steatohepatitis (MetALD) in a multi-ethnic U.S. population are limited. Additionally, impact physical activity (PA) diet quality (DQ) risk MASLD, MetALD, compensated advanced chronic (cACLD) remains unclear. This study aimed to investigate associations PA with risks cACLD. cross-sectional analyzed from 7,125 participants National Health Nutrition Examination Survey (NHANES) 2017-2020. Diet was assessed using Healthy Eating Index-2015 (HEI-2015). based 2020 WHO Physical Activity Guidelines, reporting intensity, frequency, duration their activities over past 7 days. MASLD MetALD were diagnosed clinical criteria, cACLD defined by fibrosis. Bivariate multivariable logistic regression models used assess between PA, quality, outcomes. The 35.07 21.46%, respectively. HQD associated significantly lower (OR: 0.49, 95% CI: 0.38-0.62) 0.45, 0.36-0.56). High levels linked reduced 0.47, 0.38-0.58) 0.53, 0.39-0.72). lowest for both observed highly active an (MASLD OR: 0.41, 0.32-0.53; 0.54, 0.41-0.71). Significant interactions HQD, age, BMI, SES, which further MetALD. For cACLD, increased risk. Compared non-high-activity non-HQD, physically had 0.44, 0.24-0.82). proportions US have or high

Language: Английский

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Ballaststoffe und Intervallausdauertraining – 2 Strategien zur Verbesserung von MASLD, Adipositas und kardiometabolischer Gesundheit

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

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Ernährung und körperliches Training bei Lebererkrankungen

Journal für Gastroenterologische und Hepatologische Erkrankungen, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

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