The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 DOI Creative Commons

Miaoyan Liu,

Chaofeng Gao,

Jinggeng Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

Background This research aims to explore the potential association between lung function and ratio of non-high-density lipoprotein cholesterol (NHL) high-density (NHHR). Previous has shown that lipid metabolism imbalance is closely linked cardiovascular disease, however, there a lack information regarding its impact on function. Methods used from National Health Nutrition Examination Survey (NHANES) spanning years 2007 2012, including large-scale sample 9,498 adults aged 20 older. A cross-sectional study employing multivariable regression models was aimed at examining relevance NHHR indicators (FEV1, FVC, FEV1/FVC). Adjustments were made for wide range confounding factors, encompassing race, gender, age, BMI, smoking status, physical activity, diabetes, alcohol consumption, education level. Data analysis included categorizing into quartiles using trend tests evaluate dose–response relationships Sensitivity analyses conducted by excluding participants with asthma COPD ensure reliability results. Results The results manifested significant correlation decreased FEV1 FVC values elevated NHHR, most notably within highest quartile (Q4), where pronounced. Additionally, test indicated linear negative both FVC. However, FEV1/FVC showed nonlinear U-shaped pattern. Suggesting differential impacts various indicators. findings’ robustness sensitivity analysis, which revealed even after omitting people COPD, remained significant. Conclusion emphasizes significance tracking levels in evaluating respiratory health offers early evidence favor as probable biomarker Further longitudinal occasion prove causal relationship underlying biological mechanisms.

Language: Английский

Associations of the planetary health diet index (PHDI) with asthma: the mediating role of body mass index DOI Creative Commons

Shaoqun Huang,

Qiao He,

Xiaoxuan Wang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 26, 2024

Given the global shifts in environmental conditions and dietary habits, understanding potential impact of factors body mass index (BMI) on respiratory diseases, including asthma, is paramount. Investigating these relationships can contribute to formulation more effective prevention strategies. The Planetary Health Diet Index (PHDI), a scoring system that balances human health with sustainability, underscores importance increasing consumption plant-based foods while reducing intake red meat, sugar, highly processed foods. objective this study was assess association between PHDI prevalence asthma mediation effect BMI US general population. This utilized data from 32,388 participants National Nutrition Examination Survey (NHANES) spanning 2005 2018. Multivariate logistic regression weighted quantile sum (WQS) regressions were employed investigate PHDI, individual nutrients, asthma. Restricted cubic spline (RCS) analysis explored linear or non-linear relationship Interaction analyses conducted subgroups validate findings. Mediation performed examine There significant negative After adjusting for covariates, every 10-point increase there 4% decrease (P = 0.025). Moreover, as increased, trend towards lower < 0.05). WQS showed consistent associations (OR 0.93, 95%CI: 0.88, 0.98), Fiber, Vitamin C, Protein factors. dose-response curve indicated higher associated prevalence. Additionally, significantly positively 0.001), decreases increases (β -0.64, P 0.001). indicates mediates proportion 33.85% results show strong correlation In addition, mediated relationship.

Language: Английский

Citations

11
Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011–2018 DOI Creative Commons
Sijia Yu,

Shiping Wu,

Shouxin Wei

et al.

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

Asthma is a common chronic respiratory disease whose increasing prevalence poses significant burden to human health and the economy. Several studies indicate that insulin resistance (IR) associated with asthma development. The triglyceride-glucose body mass index (TyG-BMI) novel biomarker used evaluate resistance; however, limited research exists on relationship between TyG-BMI asthma. This study aimed investigate in U.S. adults. cross-sectional utilized data from National Health Nutrition Examination Survey (NHANES) database for 2011-2018 cycles. exposure variable was of participants at baseline, which calculated based triglycerides (TG), fasting blood glucose (FBG), (BMI). primary outcome status, determined via questionnaire. We analyzed participants' baseline characteristics employed weighted multivariate logistic regression models assess correlation A subgroup analysis conducted whether influenced by other factors. In total, 8,553 were analyzed, revealing positive association as continuous variable, after adjusting confounding variables, Odds ratio (OR)(95% CI) 1.003. After further dividing into quartiles potential confounders Model 3, 0.561 times higher those highest than lowest quartile (OR: 1.561, 95% CI: 1.181, 2.065). There interaction among subgroups defined gender, coronary heart disease, stroke (interaction P < 0.05). found These results suggest has be an indicator monitor asthma, but longitudinal are needed confirm causality its utility management long-term comorbidities. Not applicable.

Language: Английский

Citations

0
The J-shaped relationship between body roundness index and adult asthma: insights from NHANES 2001–2018 DOI Creative Commons
Kai Sun, Ya‐Hui Chang, Jing Jie

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 20, 2025

Background Many studies have used Body Mass Index (BMI) to define obesity and examine its potential link adult asthma. However, BMI overlooks body fat distribution, which may significantly impact health. Unlike BMI, the Roundness (BRI) can more accurately reflect distribution. Therefore, this study examined BRI’s relationship with asthma prevalence in U.S. adults. Methods This was based on data from National Health Nutrition Examination Survey (NHANES) between 2001 2018 covered 40,052 participants. Participants were categorized into four quartile groups their BRI levels: Quartile 1 (1.05, 3.80); 2 (3.80, 5.06); 3 (5.06, 6.61); 4 (6.61, 23.48). The association assessed via weighted multivariate logistic regression, smoothed curve fitting, threshold effects, subgroup, sensitivity analysis. predictive power compared waist circumference using z -scores. Results Of population, 5,605 participants had (13.99% prevalence). After adjusting for possible confounders, results showed that higher linked greater (OR = 1.41, 95% CI:1.27, 1.56, p &lt; 0.0001). A J-shaped ( -nonlinearity 0) found, rising when surpassed 4.34. outperformed predicting (BRI: OR 1.180; BMI: 1.169; W.C.: 1.166). Subgroup analyses confirmed our results’ robustness. Conclusion Adult increases increasing levels, showing a relationship. Keeping under 4.34 is vital lowering prevalence, especially overweight or obese individuals. In addition, occurrence.

Language: Английский

Citations

0
Association between body roundness index and weight-adjusted waist index with asthma prevalence among US adults: the NHANES cross-sectional study, 2005–2018 DOI Creative Commons
Jie Xu,

Jingwen Xiong,

Xue Jiang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 21, 2025

This study investigated the connection between asthma in US individuals and their body roundness index (BRI) weight-adjusted waist (WWI). According to data from 2005–2018 National Health Nutrition Examination Survey (NHANES), 3609 of 25,578 persons survey who were 18 years age or older reported having asthma. After adjusting for all confounders, probability prevalence increased by 8% every unit rise BRI (OR = 1.08, 95% CI 1.06,1.11). The 16% WWI 1.16, 1.08,1.25). indices associated with nonlinearly correlated. inflection points threshold saturation effects 4.36 10.69, respectively (log-likelihood ratio test, P < 0.05). Relationship subgroup analyses showed that positive associations generalized across populations there was no significant interaction most subgroups. In addition, sensitivity verified robustness these results, further confirming conclusion as independent risk factors Finally, receiver operating characteristic (ROC) analysis outperformed predicting asthma, suggesting potential early screening. Overall, are important clinical applications.

Language: Английский

Citations

0
The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 DOI Creative Commons

Miaoyan Liu,

Chaofeng Gao,

Jinggeng Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

Background This research aims to explore the potential association between lung function and ratio of non-high-density lipoprotein cholesterol (NHL) high-density (NHHR). Previous has shown that lipid metabolism imbalance is closely linked cardiovascular disease, however, there a lack information regarding its impact on function. Methods used from National Health Nutrition Examination Survey (NHANES) spanning years 2007 2012, including large-scale sample 9,498 adults aged 20 older. A cross-sectional study employing multivariable regression models was aimed at examining relevance NHHR indicators (FEV1, FVC, FEV1/FVC). Adjustments were made for wide range confounding factors, encompassing race, gender, age, BMI, smoking status, physical activity, diabetes, alcohol consumption, education level. Data analysis included categorizing into quartiles using trend tests evaluate dose–response relationships Sensitivity analyses conducted by excluding participants with asthma COPD ensure reliability results. Results The results manifested significant correlation decreased FEV1 FVC values elevated NHHR, most notably within highest quartile (Q4), where pronounced. Additionally, test indicated linear negative both FVC. However, FEV1/FVC showed nonlinear U-shaped pattern. Suggesting differential impacts various indicators. findings’ robustness sensitivity analysis, which revealed even after omitting people COPD, remained significant. Conclusion emphasizes significance tracking levels in evaluating respiratory health offers early evidence favor as probable biomarker Further longitudinal occasion prove causal relationship underlying biological mechanisms.

Language: Английский

Citations

0