Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 10, 2025

Diabetic kidney disease is one of the common complications in diabetic patients and has gradually become an important pathogenic factor chronic disease. Therefore, studying mechanisms its occurrence development great significance for prevention treatment Some researchers have pointed out that there a phenomenon hypoxia tissue believe hypoxia-inducible factor-1α closely related to progression Additionally, homeostasis zinc plays key role body's adaptation hypoxic environments. However, specific relationship among these three factors remains unclear. This article provides detailed review multiple roles pathogenesis disease, including: regulating angiogenesis, increasing expression erythropoietin, modulating oxidative stress through PI3K/AKT HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration release induce responses, facilitating epithelial-mesenchymal transition, pathological fibrotic factors, ultimately leading renal fibrosis. Furthermore, HIF-1α also participates such as apoptosis, inducing mitochondrial autophagy, vascular calcification. At same time, this clarifies regulatory trace element on references insights further research

Language: Английский

Blood arsenic levels and heart valve disease: A Mendelian randomization study

Published: Jan. 10, 2025

Language: Английский