Association of triglyceride-glucose index and derived indices with cataract in middle-aged and elderly Americans: NHANES 2005–2008

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

Abstract Aim Explore the relationship between triglyceride-glucose (TyG) index, along with its derivative indices, and prevalence of cataracts. Methods Data from 20,497 participants in 2005–2008 National Health Nutrition Examination Survey (NHANES) were compiled. A final total 4,499 individuals met eligibility criteria. Cataract presence was assessed through a self-reported history cataract surgery. The TyG index derivatives—TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte (NLR), TyG-monocyte-to-lymphocyte (MLR), TyG-log platelet-to-lymphocyte (lgPLR), systemic inflammation (lgSII), TyG-systemic response (SIRI)—were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, receiver operating characteristic (ROC) analysis. Results Higher indices significantly associated ( P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, TyG-SIRI exhibited positive correlations prevalence, even after adjustment potential confounders (odds [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; 0.0403; 1.01; 1.00, 1.02; 0.0258; 1.08; 1.16; 0.0223; 1.03, 1.14; 0.001; 1.04; 0.0120). Furthermore, stratified analysis showed that 61–85 age group, TyG-lgPLR TyG-lgSII remained positively ([OR] 1.09; 0.024; 1.02, 1.13; 0.005). RCS revealed linear association these cataracts, no apparent threshold effect. ROC indicated TyG-MLR demonstrated highest predictive ability presence. Conclusion study results indicate TyG-related indicators cataracts middle-aged elderly individuals, suggesting markers may serve as practical biomarkers identifying high-risk individuals. Early detection management metabolic inflammatory factors could contribute to effective preventive strategies development population.

Language: Английский

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Association between METS-IR and female infertility: a cross-sectional study of NHANES 2013–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 28, 2025

Background Obesity and metabolic syndrome are significant contributors to infertility in women closely associated with insulin resistance (IR). The score for (METS-IR) is a new, non-insulin-based fasting index used measure IR. However, the potential of METS-IR as predictive indicator female risk has not been established. This study aimed explore association between infertility. Methods cross-sectional data from National Health Nutrition Examination Survey (NHANES) 2013 2018. We conducted multivariate logistic regression, restricted cubic spline (RCS), threshold effect analyses investigate relationship Results According self-reported data, 188 (12.20%) participants were classified infertile. A significantly higher proportion elevated found have Multivariable regression analysis revealed that was increased infertility, irrespective independent variable by continuous variables or tertiles fully adjusted model (Model 3, variable: OR = 1.02, 95% confidence interval (CI):1.01–1.04, p 0.005; tertile 3 vs. 1: 2.00, CI 1.21–3.28, 0.0128, trend =0.0126). RCS indicated linear correlation ( 0.121), further supported this 0.136). Moreover, above inflection point 32.94, increasing level &lt; 0.0001). Conclusion Our results suggest high levels positively among reproductive-aged females United States.

Language: Английский

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Association of insulin resistance indices with kidney stones and their recurrence in a non-diabetic population: an analysis based on NHANES data from 2007–2018

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 24, 2025

To systematically evaluate the association between insulin resistance indices and risk of kidney stones their recurrence in U.S. non-diabetic individuals, while identifying predictive indicators. This cross-sectional study analyzed data from 2007-2018 NHANES. Five IR were calculated. Weighted logistic regression, restricted cubic spline, mediation analyses used to assess independent associations these individuals. 9,605 participants showed an overall incidence 8.63% a rate 2.70%. regression RCS revealed significant positive METs-IR, HOMA-IR, TyG-BMI, recurrence. Every unit increase METs-IR was linked 2% rise (95% CI: 1.014-1.027, p < 0.001) 3.3% 1.018-1.048, 0.001); each HOMA-IR raised by 5% 1.025-1.078, 7.9% 1.041-1.118, 0.001). Adjusting for confounders shifted relationships nonlinear linear (p > 0.05). demonstrated strongest diagnostic accuracy predicting recurrence, with uric acid vitamin D mediating found that elevated (METs-IR, TyG-BMI) significantly increased stone population. Serum mediated this association, best

Language: Английский

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The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001–2018

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

The association between the triglyceride-glucose (TyG) index and mortality in general population remains controversial, with inconsistent findings across studies.

Language: Английский

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