Mapping the Scientific Research on Nutrition and Mental Health: A Bibliometric Analysis

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 399 - 399

Published: Jan. 22, 2025

Background/Objectives: The connection between nutrition and mental health has become a point of growing interest. In response, nutritional psychiatry research emerged as field dedicated to understanding these interactions. A bibliometric analysis was conducted map the growth trends in this area, providing insights into its evolving scope key contributions. Methods: literature search within Web Science Core Collection. Data performed using result citation report options well visualization software VOSviewer (Version 1.6.20). Results: total 31,556 articles on were published from 2000 2024 across various WoS categories, mainly “Psychiatry”, “Public, Environmental & Occupational Health”, “Nutrition Dietetics”. most prolific groups are based North America. Recent publications cover seven clusters: (1) public social factors, (2) interventions biological mechanisms, (3) elderly, (4) nutrition-related illnesses, (5) lifestyle behavior, (6) observational studies, (7) pregnancy postpartum period. Conclusions: view increasing activities allocation resources research, it is important define priorities close collaboration with service users stakeholders. Research should be approached holistic manner through multidisciplinary consortia ensure comprehensive impactful outcomes.

Language: Английский

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Amid Growing Evidence of Conflicts of Interest and Obdurate Groupthink in Medical Journals, Researchers Must Entertain Contrarian Ideas

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Mainstream medicine, like other academic fields, is shaped by prevailing paradigms and the dominant narratives they create. Over past half-century, these have increasingly reflected growing commercial influence of pharmaceutical industry. Dominant are closely tied to groupthink, which medical journals often subject. In addition, more "prestigious" tend further financial conflicts interest with These dynamics limit scientific progress suppressing awareness iatrogenic aspects industry products benefits alternative non-patentable unpatentable therapeutic interventions. Journals need adopt a open policy manuscripts that encompass contrarian perspectives while still adhering time-tested values methods.

Language: Английский

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Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Background and Hypothesis Convergent evidence shows the presence of brain metabolic abnormalities in psychotic disorders. This study examined reductive stress energy metabolism people with disorders impaired or average range cognition. We hypothesized that global cognitive impairment would be associated greater dysregulation. Study Design Participants affective non-affective psychosis (n = 62) were administered MATRICS Consensus Cognitive Battery (MCCB) underwent a 31P-magnetic resonance spectroscopy scan at 4T. used cluster-analysis approach to identify 2 clusters participants without dysfunction. compared on redox balance stress, measured by ratio nicotinamide adenine dinucleotide (NAD+) its reduced form NADH, addition creatine kinase (CK) enzymatic activity pH. Results The mean (SD) age was 25.1 (6.3) years. NAD+/NADH differed between groups, lower ratio, suggesting more cluster (t −2.60, P .01). There also significant reduction CK −2.19, .03). Intracellular pH did not differ groups 1.31, .19). significantly severity mood symptomatology other measures illness severity. Conclusions Our results demonstrate have dysregulation, decrease rate markers. provides new for potential emerging therapies treat deficits

Language: Английский

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Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 7, 2025

Schizoaffective disorder is a severe psychiatric condition characterized by mood disturbances and psychotic symptoms. Standard treatments, primarily pharmacological, often fail to control symptoms fully can lead significant metabolic side effects. Emerging evidence suggests that ketogenic therapy (KMT), also known as the diet, may offer powerful alternative conventional treatments for components resolve in patients with schizoaffective disorder. This case series investigates effects of KMT on two individuals diagnosed who pursued this due ineffectiveness treatments. Both presentations followed modified diet medical oversight. Symptom changes were assessed using validated tools, including Generalized Anxiety Disorder-7 (GAD-7), Depression Stress Scales (DASS-42), PTSD Checklist DSM-5 (PCL-5), Patient Health Questionnaire-9 (PHQ-9). experienced complete cessation improvements mood. Case 1, 17-year-old female, achieved full remission suicidal ideation, hallucinations, anxiety within 6 weeks, sustained at 24-week follow-up. 2, 32-year-old chronic months. Patients either deprescription or process time demonstrates disorder, leading functional recovery reported quality life extend beyond symptom standard care interventions.

Language: Английский

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Keto-Therapy: Unveiling the Potential of Ketogenic Diet in Psychiatric Care - A Scoping Review

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112710 - 112710

Published: Feb. 1, 2025

Language: Английский

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The effect of exogenous ketones on signs and symptoms of schizophrenia spectrum and bipolar disorders: study protocol for a triple-blind, randomized, controlled cross-over pilot study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract Introduction Inflammation, oxidative stress, and bioenergetic dysfunction are proposed underlying mechanisms of schizophrenia spectrum disorders (SSD) bipolar (BD), contributing to the largely untreated cognitive negative symptoms in these conditions. Ketone bodies may offer a therapeutic option for through their positive effects on aforementioned mechanisms. Exogenous ketones like ketone esters (KE) provide means quickly induce ketosis without dietary restrictions, though SSD BD have not yet been investigated. Here, we describe study protocol an ongoing triple-blind, randomized controlled crossover trial single ingestion KE signs BD. Methods A total 24 patients (12 SSD, 12 BD) receiving inpatient care at Amsterdam UMC will be included study. Patients ingest dose ((R)-3-hydroxybutyl-(R)-3-hydroxybutyrate deltaG® - dGK) isocaloric carbohydrate control with washout period three days between drinks. The primary outcome is change pre-pulse inhibition startle reflex (PPI) induced by dGK compared control. Secondary outcomes include resting-state EEG, P3B amplitude, performance, metabolic, immune, stress circadian rhythm parameters. Feasibility potential side also assessed. Discussion Our current offers valuable preliminary data patients. It can foundation future research into alleviating improving functional disorders. Trial registration www.ClinicalTrials.gov , ID: NCT06426134 .

Language: Английский

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Therapeutic effects of ketogenic diets on physiological and mental health

Published: March 25, 2025

Ketogenic diets are emerging dietary patterns that have demonstrated potential as therapeutic tools in a variety of symptoms and conditions, such epileptic seizures, diabetes, obesity, cancer, migraines, metabolic syndrome. This narrative review examines the effects ketogenic on physiological mental health, including their role modulating gut microbiome. promote weight loss, enhance insulin sensitivity, may lower dyslipidemia, which crucial factors preventing cardio-metabolic diseases. They also play significant composition function microbiome, serving approach to control autoimmune diseases, given effectiveness reducing pro-inflammatory cells. Conversely, downside these is decrease beneficial bacteria been positively associated with human health. Regarding capability stabilize neural networks, improve neuroplasticity, exert direct benefits brain bioenergetics, thereby potentially alleviating related several epilepsy, anxiety, depression, schizophrenia, bipolar disorder, autism spectrum certain neurodegenerative However, more randomized, long-term studies required assess efficacy, sustainability, safety, methodological rigor strengthen findings impacts.

Language: Английский

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Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework

Psychiatry Research, Journal Year: 2024, Volume and Issue: 342, P. 116220 - 116220

Published: Oct. 2, 2024

Language: Английский

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Ketogenic diets in clinical psychology: examining the evidence and implications for practice

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 26, 2024

Introduction The application of ketogenic dietary interventions to mental health treatments is increasingly acknowledged within medical and psychiatric fields, yet its exploration in clinical psychology remains limited. This article discusses the potential implications diets, traditionally utilized for neurological disorders, broader practices. Methods presents a perspective based on existing diet research historical use, biological mechanisms, therapeutic benefits. It examines these diets treatment their relevance practice. Results review informs psychologists benefits introduces literature underlying mechanisms involved, such as modulation neurotransmitters, reduction inflammation, stabilization brain energy metabolism, demonstrating biopsychosocial practice psychology. Conclusion By considering metabolic therapies, can broaden scope integration provides care model that incorporates knowledge option care. emphasizes need further training support effective implementation this psychiatry intervention.

Language: Английский

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Ketogenic Diet as a Nutritional Metabolic Intervention for Obsessive–Compulsive Disorder: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 31 - 31

Published: Dec. 25, 2024

The substantial evidence supporting the ketogenic diet (KD) in epilepsy management has spurred research into its effects on other neurological and psychiatric conditions. Despite differences characteristics, symptoms, underlying mechanisms, these conditions share common pathways that KD may influence. reverses metabolic dysfunction. Moreover, it been shown to support neuroprotection through mechanisms such as neuronal energy support, inflammation reduction, amelioration of oxidative stress, reversing mitochondrial adequate intake dietary nutrients is essential for maintaining normal brain functions, strong supports role nutrition treatment prevention many disorders. Obsessive–compulsive disorder (OCD) a neuropsychiatric condition marked by persistent, distressing thoughts or impulses (obsessions) repetitive behaviors performed response obsessions (compulsions). Recent studies have increasingly examined disorders OCD. This narrative review examines current potential We explore KD’s assess relevance OCD treatment. Additionally, we identify key gaps preclinical clinical warrant further study applying therapy

Language: Английский

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