The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 2: Comorbidities

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1487 - 1487

Published: April 28, 2025

Pediatric obesity is associated with a wide range of comorbidities beyond metabolic changes, affecting cardiovascular, endocrine, reproductive, musculoskeletal systems, and also mental health. Hypertension, commonly observed in children obesity, increases the risk long-term cardiovascular disease. Polycystic ovary syndrome (PCOS) presents another significant endo-reproductive challenge that often develops during adolescence females, leading to further adulthood. Additionally, excess adiposity can negatively impact bone health by modifying metabolism increasing fracture risk. Obesity strongly linked disorders, including depression, anxiety, low self-esteem, which exacerbate unhealthy lifestyle behaviors disorders. Given limitations poor adherence traditional treatment strategies, nutraceuticals have emerged as potential complementary therapies due their bioactive properties. Various compounds demonstrated antihypertensive, insulin-sensitizing, anti-inflammatory effects, while others support promote well-being. Herewith, we discuss role managing hypertension, PCOS, health, issues individuals evaluating mechanisms action clinical relevance. Integrating nutraceutical dietary interventions may improve outcomes prevent obesity-related comorbidities. Further, emphasize need for large-scale studies, especially pediatric patients.

Language: Английский

Exploring the In Vitro Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell Lines

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 693 - 693

Published: Dec. 9, 2024

Ensuring adequate bone health is crucial for preventing conditions such as osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained attention its potential benefits in health. This study evaluated the osteoprotective of zingerone effects on differentiation signalling pathways

Language: Английский