Exploring the Link Between Vitamin K and Depression: A Systematic Review DOI Creative Commons

M. Hashim,

Nik Nasihah Nik Ramli,

Siti Nur Atiqah Zulaikah Nasarudin

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 861 - 861

Published: May 7, 2025

Background and Objectives: Depression is a multifactorial mental health disorder involving inflammation, oxidative stress, neuroplasticity deficits, metabolic dysfunction. Emerging research suggests that vitamin K, beyond its classical roles in coagulation bone metabolism, may influence neurobiological processes relevant to mood regulation. This systematic review evaluates the association between K depressive symptoms explores potential underlying mechanisms. Materials Methods: A search was conducted across PubMed, Scopus, Cochrane Library, ScienceDirect, Google Scholar, following PRISMA 2020 guidelines. Eligible studies included human or animal examining associations status (dietary intake serum levels) depression-related outcomes. Fourteen met inclusion criteria: eleven observational studies, one randomized controlled trial (RCT), two preclinical studies. Results: Most reported an inverse levels diverse populations. One small RCT demonstrated modest improvements depression scores K2 (menaquinone-7) supplementation women with polycystic ovary syndrome. Two using non-depression models behavioral reduced stress administration. Conclusions: While preliminary findings suggest role for pathways depression, current evidence limited by cross-sectional designs, lack of isoform-specific analyses, absence depression-focused models. Mechanisms including inflammation reduction, modulation, sphingolipid regulation, K-dependent protein signaling (e.g., GAS6 osteocalcin) were discussed based on indirect require further investigation depression-specific contexts.

Language: Английский

Exploring the Link Between Vitamin K and Depression: A Systematic Review DOI Creative Commons

M. Hashim,

Nik Nasihah Nik Ramli,

Siti Nur Atiqah Zulaikah Nasarudin

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 861 - 861

Published: May 7, 2025

Background and Objectives: Depression is a multifactorial mental health disorder involving inflammation, oxidative stress, neuroplasticity deficits, metabolic dysfunction. Emerging research suggests that vitamin K, beyond its classical roles in coagulation bone metabolism, may influence neurobiological processes relevant to mood regulation. This systematic review evaluates the association between K depressive symptoms explores potential underlying mechanisms. Materials Methods: A search was conducted across PubMed, Scopus, Cochrane Library, ScienceDirect, Google Scholar, following PRISMA 2020 guidelines. Eligible studies included human or animal examining associations status (dietary intake serum levels) depression-related outcomes. Fourteen met inclusion criteria: eleven observational studies, one randomized controlled trial (RCT), two preclinical studies. Results: Most reported an inverse levels diverse populations. One small RCT demonstrated modest improvements depression scores K2 (menaquinone-7) supplementation women with polycystic ovary syndrome. Two using non-depression models behavioral reduced stress administration. Conclusions: While preliminary findings suggest role for pathways depression, current evidence limited by cross-sectional designs, lack of isoform-specific analyses, absence depression-focused models. Mechanisms including inflammation reduction, modulation, sphingolipid regulation, K-dependent protein signaling (e.g., GAS6 osteocalcin) were discussed based on indirect require further investigation depression-specific contexts.

Language: Английский

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