Critical Reviews in Microbiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 18
Published: April 8, 2024
Ferroptosis
is
a
new
type
of
cell
death,
which
mainly
dependent
on
the
formation
and
accumulation
reactive
oxygen
species
lipid
peroxides
mediated
by
iron.
It
distinct
from
other
forms
regulation
death
in
morphology,
immunology,
biochemistry,
molecular
biology.
Various
mechanisms
have
been
observed
many
viral
infections,
virus-induced
has
long
considered
as
double-edged
sword
that
can
inhibit
or
aggravate
infections.
However,
understanding
role
ferroptosis
various
infections
limited.
Special
attention
will
be
paid
to
mediating
infection
antiviral
treatment
associated
with
ferroptosis.
In
this
paper,
we
outlined
mechanism
Additionally,
paper
also
review
research
perspective
virus,
discussed
status
virus
classified
summarized
interaction
between
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(22), P. 12234 - 12234
Published: Nov. 12, 2021
Disease
relapse
and
therapy
resistance
remain
key
challenges
in
treating
multiple
myeloma.
Underlying
(epi-)mutational
events
can
promote
myelomagenesis
contribute
to
multi-drug
apoptosis
resistance.
Therefore,
compounds
inducing
ferroptosis,
a
form
of
iron
lipid
peroxidation-regulated
cell
death,
are
appealing
alternative
treatment
strategies
for
myeloma
other
malignancies.
Both
ferroptosis
the
epigenetic
machinery
heavily
influenced
by
oxidative
stress
metabolism
changes.
Yet,
only
limited
number
enzymes
modifications
have
been
identified
as
regulators.
In
this
study,
we
found
that
MM1
cells
sensitive
induction
reprogramming
RSL3,
irrespective
their
glucocorticoid-sensitivity
status.
LC-MS/MS
analysis
revealed
formation
non-heme
iron-histone
complexes
altered
expression
histone
associated
with
DNA
repair
cellular
senescence.
line
observation,
EPIC
BeadChip
measurements
significant
methylation
changes
ferroptotic
demonstrated
an
enrichment
CpG
probes
located
genes
cycle
progression
senescence,
such
Nuclear
Receptor
Subfamily
4
Group
A
member
2
(NR4A2).
Overall,
our
data
show
death
is
epigenomic
response
might
advance
therapeutic
applicability
compounds.
Anticancer Research,
Journal Year:
2022,
Volume and Issue:
42(12), P. 5719 - 5729
Published: Dec. 1, 2022
Gastric
cancer
(GC)
is
the
fourth
leading
cause
of
cancer-related
death
worldwide.
Glutathione
peroxidase
4
(GPX4)
a
glutathione-dependent
antioxidant
enzyme
known
to
regulate
ferroptosis,
which
non-apoptotic
form
cell
accompanied
by
iron-dependent
accumulation
reactive
oxygen
species
(ROS).
This
study
evaluated
expression
and
function
GPX4
in
GC.The
was
examined
five
human
GC
lines
(KATO-III,
MKN-1,
MKN-28,
MKN-45,
MKN-74)
using
real-time
quantitative
PCR
western
blotting.
The
role
small
interference
RNA
proliferation
ROS
assays.
Finally,
we
analyzed
tumor
tissues
from
106
patients
who
underwent
surgery
immunohistochemistry
relationship
between
levels
clinical
outcomes
GC.GPX4
expressed
all
at
various
levels.
silencing
inhibition
significantly
reduced
increased
generation.
Furthermore,
mRNA
prostaglandin-endoperoxide
synthase
2,
biomarker
were
after
silencing.
found
be
an
independent
prognostic
factor
for
overall
disease-specific
survival
patients.GPX4
can
via
ferroptosis
represents
significant
risk
with
GC.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
40(1-3), P. 40 - 85
Published: May 3, 2023
The
multifactorial
nature
of
the
mechanisms
implicated
in
cancer
development
still
represents
a
major
issue
for
success
established
antitumor
therapies.
discovery
ferroptosis,
novel
form
programmed
cell
death
distinct
from
apoptosis,
along
with
identification
molecular
pathways
activated
during
its
execution,
has
led
to
uncovering
molecules
characterized
by
ferroptosis-inducing
properties.
Critical Reviews in Microbiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 18
Published: April 8, 2024
Ferroptosis
is
a
new
type
of
cell
death,
which
mainly
dependent
on
the
formation
and
accumulation
reactive
oxygen
species
lipid
peroxides
mediated
by
iron.
It
distinct
from
other
forms
regulation
death
in
morphology,
immunology,
biochemistry,
molecular
biology.
Various
mechanisms
have
been
observed
many
viral
infections,
virus-induced
has
long
considered
as
double-edged
sword
that
can
inhibit
or
aggravate
infections.
However,
understanding
role
ferroptosis
various
infections
limited.
Special
attention
will
be
paid
to
mediating
infection
antiviral
treatment
associated
with
ferroptosis.
In
this
paper,
we
outlined
mechanism
Additionally,
paper
also
review
research
perspective
virus,
discussed
status
virus
classified
summarized
interaction
between
