Cancer Cell International,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: July 5, 2022
Abstract
Bioactive
lipid
molecules
have
been
proposed
to
play
important
roles
linking
obesity/metabolic
syndrome
and
cancers.
Studies
reveal
that
aberrant
metabolic
signaling
can
reprogram
cancer
cells
non-cancer
in
the
tumor
microenvironment,
contributing
initiation,
progression,
metastasis,
recurrence,
poor
therapeutic
response.
Existing
evidence
indicates
controlling
metabolism
be
a
potential
strategy
for
prevention
therapy.
By
reviewing
current
literature
on
various
cancers,
we
summarized
major
including
fatty
acids
cholesterol
as
well
droplets
discussed
their
critical
terms
of
either
promoting-
or
anti-tumorigenesis.
This
review
provides
an
overview
cellular
entities
adding
existing
knowledge
with
reprogramming
immune
associated
cells.
Comprehensive
understanding
regulatory
role
microenvironment
will
provide
new
direction
further
studies,
shift
away
from
conventional
research.
Exploring
lipid-related
targets
drive
block
development
may
lead
novel
anti-cancer
strategies
distinct
traditional
approaches
treatment.
Seminars in Cancer Biology,
Journal Year:
2022,
Volume and Issue:
86, P. 93 - 100
Published: Sept. 9, 2022
The
energy
metabolism
of
tumor
cells
is
considered
one
the
hallmarks
cancer
because
it
different
from
normal
and
mainly
consists
aerobic
glycolysis,
fatty
acid
oxidation,
glutaminolysis.
It
about
hundred
years
ago
since
Warburg
observed
that
prefer
glycolysis
even
in
normoxic
conditions,
favoring
their
high
proliferation
rate.
A
pivotal
enzyme
driving
this
phenomenon
lactate
dehydrogenase
(LDH),
review
describes
prognostic
therapeutic
opportunities
associated
with
enzyme,
focussing
on
tumors
limited
strategies
life
expectancy
(i.e.,
pancreatic
thoracic
cancers).
Expression
levels
LDH-A
tissues
correlate
clinicopathological
features:
overexpressed
during
carcinogenesis
showed
significantly
higher
expression
more
aggressive
tumors.
Similarly,
LDH
are
a
marker
negative
prognosis
patients
both
adenocarcinoma
or
squamous
cell
lung
carcinoma,
as
well
malignant
pleural
mesothelioma.
Additionally,
serum
may
play
key
role
clinical
management
these
diseases
they
tissue
damage
induced
by
burden.
Lastly,
we
discuss
promising
results
targeting
treatment
strategy,
reporting
recent
preclinical
translational
studies
supporting
use
LDH-inhibitors
combinations
current/novel
chemotherapeutics
can
synergistically
target
oxygenated
present
tumor.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3142 - 3142
Published: March 8, 2024
The
Warburg
effect,
characterized
by
the
preferential
conversion
of
glucose
to
lactate
even
in
presence
oxygen
and
functional
mitochondria,
is
a
prominent
metabolic
hallmark
cancer
cells
has
emerged
as
promising
therapeutic
target
for
therapy.
Elevated
levels
acidic
pH
within
tumor
microenvironment
(TME)
resulting
from
glycolytic
profoundly
impact
various
cellular
populations,
including
macrophage
reprogramming
impairment
T-cell
functionality.
Altogether,
effect
been
shown
promote
progression
immunosuppression
through
multiple
mechanisms.
This
review
provides
an
overview
current
understanding
its
implications.
We
summarize
recent
pharmacological
strategies
aimed
at
targeting
enzymes,
highlighting
challenges
encountered
achieving
efficacy.
Additionally,
we
examine
utility
early
diagnostic
tool.
Finally,
discuss
multifaceted
roles
TME,
emphasizing
potential
disrupt
interactions
between
immune
cells,
thereby
enhancing
anti-tumor
immunity.
Clinical & Experimental Metastasis,
Journal Year:
2024,
Volume and Issue:
41(3), P. 163 - 186
Published: Jan. 19, 2024
Abstract
Small
non-coding
RNA
or
microRNA
(miRNA)
are
critical
regulators
of
eukaryotic
cells.
Dysregulation
miRNA
expression
and
function
has
been
linked
to
a
variety
diseases
including
cancer.
They
play
complex
role
in
cancers,
having
both
tumour
suppressor
promoter
properties.
In
addition,
single
can
be
involved
regulating
several
mRNAs
many
miRNAs
regulate
mRNA,
therefore
assessing
these
roles
is
essential
better
understanding
cancer
initiation
development.
Pancreatic
leading
cause
death
worldwide,
part
due
the
lack
diagnostic
tools
limited
treatment
options.
The
most
common
form
pancreatic
cancer,
ductal
adenocarcinoma
(PDAC),
characterised
by
major
genetic
mutations
that
drive
progression.
regulation
interaction
with
driving
suggests
strong
link
between
two.
Understanding
this
PDAC
progression
may
give
rise
novel
treatments
tools.
This
review
summarises
PDAC,
downstream
signalling
pathways
they
in,
how
being
used
studied
as
therapeutic
targets
well
prognostic/diagnostic
improve
clinical
outcome
PDAC.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1879(4), P. 189120 - 189120
Published: May 25, 2024
Carbonic
anhydrases
(CAs),
are
metallo-enzymes
implicated
in
several
pathophysiological
processes
where
tissue
pH
regulation
is
required.
CA
IX
a
tumor-associated
isoform
induced
by
hypoxia
and
involved
the
adaptation
of
tumor
cells
to
acidosis.
Indeed,
tumor-driving
pathways
can
induce
expression,
this
turn
has
been
associated
cancer
invasion
metastatic
features
as
well
induction
stem-like
features,
drug
resistance
recurrence.
After
its
functional
structural
characterization
targeting
approaches
have
developed
inhibit
activity
neoplastic
tissues,
date
field
seen
an
incredible
acceleration
terms
therapeutic
options
biological
readouts.
Small
molecules
inhibitors,
hybrid/dual
drugs,
antibodies
adoptive
(CAR-T
based)
cell
therapy
at
preclinical
level,
whereas
sulfonamide
inhibitor
antibody
entered
Phase
Ib/II
clinical
trials
for
treatment
imaging
different
solid
tumors.
Here
recent
advances
on
biology
pharmacology
cancer,
will
be
discussed.
iScience,
Journal Year:
2024,
Volume and Issue:
27(6), P. 109979 - 109979
Published: May 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1659 - 1659
Published: Jan. 31, 2022
Mitochondrial
DNA
(mtDNA)
has
been
identified
as
a
significant
genetic
biomarker
in
disease,
cancer
and
evolution.
Mitochondria
function
modulators
for
regulating
cellular
metabolism.
In
the
clinic,
mtDNA
variations
(mutations/single
nucleotide
polymorphisms)
dysregulation
of
mitochondria-encoded
genes
are
associated
with
survival
outcomes
among
patients.
On
other
hand,
nuclear-encoded
have
found
to
regulate
gene
expression,
turn
mitochondrial
homeostasis.
These
observations
suggest
that
crosstalk
between
nuclear
genome
is
important
function.
Therefore,
this
review
summarizes
mechanisms
functional
roles
(DNA
level)
mtDNA-encoded
(RNA
protein
levels)
cancers
discusses
new
genome.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3710 - 3710
Published: Feb. 13, 2023
Hepatocellular
carcinoma
is
today
the
sixth
leading
cause
of
cancer-related
death
worldwide,
despite
decreased
incidence
chronic
hepatitis
infections.
This
due
to
increased
diffusion
metabolic
diseases
such
as
syndrome,
diabetes,
obesity,
and
nonalcoholic
steatohepatitis
(NASH).
The
current
protein
kinase
inhibitor
therapies
in
HCC
are
very
aggressive
not
curative.
From
this
perspective,
a
shift
strategy
toward
may
represent
promising
option.
Here,
we
review
knowledge
on
dysregulation
therapeutic
approaches
targeting
pathways.
We
also
propose
multi-target
approach
possible
new
option
pharmacology.
