Invasion and metastasis in cancer: molecular insights and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

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Dual-target nanotherapy for vascular endothelium and bone mesenchymal stem cells halt steroid-induced osteonecrosis of the femoral head progression

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 219 - 239

Published: Feb. 5, 2025

Language: Английский

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Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1075 - 1075

Published: May 13, 2024

The phenomenon of bone metastases presents a significant challenge within the context advanced cancer treatments, particularly pertaining to breast, prostate, and lung cancers. These metastatic occurrences stem from dissemination cancerous cells into bone, thereby interrupting equilibrium between osteoblasts osteoclasts. Such disruption results in skeletal complications, adversely affecting patient morbidity quality life. This review discusses intricate interplay microenvironment, positing not merely as passive recipient but an active contributor progression through its distinctive biochemical cellular makeup. A thorough examination structure dynamics remodeling is undertaken, elucidating how exploit these processes. explores genetic molecular pathways that underpin onset development metastases. Particular emphasis placed on roles cytokines growth factors facilitating osteoclastogenesis influencing osteoblast activity. Additionally, this paper offers meticulous critique current diagnostic methodologies, ranging conventional radiography imaging techniques, implications nuanced understanding metastasis biology for therapeutic intervention. includes targeted therapies strategies managing pain other skeletal-related events. Moreover, underscores imperative ongoing research efforts aimed at identifying novel targets refining management approaches It advocates multidisciplinary strategy integrates advancements medical oncology radiology with insights derived genetics, enhance prognostic outcomes life patients afflicted by debilitating condition. In summary, constitute complex issue demands comprehensive informed approach treatment. article contributes discourse consolidating existing knowledge avenues future investigation, overarching objective ameliorating care domain oncology.

Language: Английский

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New Image Processing Method for Plain Radiography Improves Detection of Bone Metastases

Journal of Nippon Medical School, Journal Year: 2025, Volume and Issue: 92(1), P. 37 - 43

Published: Feb. 25, 2025

Background: Diagnosis of bone metastases would be hastened if they could detected on plain radiographs obtained at the first visit to an orthopedic surgeon. However, lesions are often undetectable radiography. Bone metastasis is diagnosed in only a few patients, and diagnosis delayed many cases. We investigated diagnostic performance radiography that used new image processing method, Dynamic Visualization II (DV), diagnose metastases. Methods: enrolled 29 patients with symptomatic pelvic who visited our hospital between April 2018 March 2021. The evaluation images were created by original data default settings for DV (Presets 1-4). Processing Preset 1 resulted converted conventional film parameters, whereas Presets 2-4 utilized different methods. readers six trainees, reading time was 30 seconds per image. rate correct answers processed compared rates those other presets. Additionally, analyzed relation clinical variables. Results: answer significantly higher 3 (43.7%) 4 (42.5%) than (28.7%). Correct elderly male innominate lesions, osteolytic metastases, normal body weight. Conclusions: Image improved might hasten help prevent associated complications.

Language: Английский

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Lung Adenocarcinoma With Bone Metastases: Clinicogenomic Profiling and Insights Into Prognostic Factors

Cancer Control, Journal Year: 2025, Volume and Issue: 32

Published: Feb. 1, 2025

Introduction Lung adenocarcinoma is the leading cause of cancer-related mortality worldwide. Understanding clinicopathological profiles and genomic drivers its metastatic patterns a crucial step for risk stratification. Herein, we investigated clinicogenomic features bone metastases in lung their prognostic value. Methods A retrospective cohort study with total 4064 patients various were included, obtaining relevant clinical data profiles. Patients categorized based on presence or absence metastases. comparative analysis both groups terms demographics, disease status, somatic mutations, microsatellite instability was carried out. Significantly different variables tested association Cox regression analyses utilized to identify independent survival sub-cohort. Results Gender, concomitant (to adrenal gland, nervous system, lymph nodes, liver, lung, mediastinum, pleura, skin), aberrations TP53 , EGFR KEAP1 MYC associated adenocarcinoma. Survival within sub-cohort have illustrated following possess poor signature including age > 75, female gender, White ethnicity, distant (adrenal central intra-abdominal, liver), (wild type), (mutant), KRAS SMARCA4 (mutant). Conclusion Key factors been highlighted, providing exploratory insights into high-risk individuals. Future studies should be directed validate these larger, more diverse cohorts enhance generalizability.

Language: Английский

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Lipid metabolism dysregulation for bone metastasis and its prevention

Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Bone metastasis often develops in advanced malignancies. Lipid metabolic dysregulation might play pivotal role cancer progression and subsequent deterioration of bone health at metastatic condition. In-depth understanding lipid reprogramming metastasized cells other stromal including marrow adipocyte (BMA) is an urgent need to develop effective therapy. This paper emphasizes providing overview multifaceted dysregulated lipids BMA association with by utilizing search terms metabolism, PubMed. study extends address mechanism linked metabolism various crucial genes (e.g. CSF-1, RANKL, NFkB NFATc1) involved metastasis. review examines therapeutic strategies targeting offer potential avenues disrupt lipid-driven On condition, molecules especially not only favors but also potentiate within cells. Distinct lipid-metabolism associated may act as biomarker, these challenging task for specific treatment. Curbing function resorption controlling drugs statins, omega-3 FA metformin) provide additional support curtail lipid-associated

Language: Английский

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Oxymatrine and Gut Microbiota Modulation: A Potential Therapeutic Strategy for Bone Cancer Pain Management

Journal of Pain, Journal Year: 2024, Volume and Issue: 25(10), P. 104588 - 104588

Published: June 5, 2024

Language: Английский

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Biomimetic engineered nanoparticles target drug-resistant tumor cells and heterogeneous blood vessels for combination therapy of osteosarcoma

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 149761 - 149761

Published: Feb. 16, 2024

Given that the treatment of drug-resistant osteosarcoma is a significant clinical challenge, in tumors, role endothelial cells has been recently emphasized. We noted heterogeneous vascular (HVECs) tissues may inhibit macrophage-mediated killing tumor cells, thus promoting occurrence drug resistance. Accordingly, we designed type hybrid membrane-coated multifunctional nanoparticle (NP), SiO2@PDA/Fe3+@Cis@HM. The NPs had good biocompatibility and enhanced low-temperature photothermal Fenton-like reactions. membrane endowed with homing ability homologous cell targeting ability, simultaneously HVECs, addition to via efficient delivery cisplatin ROS produced by accelerated Through vivo vitro experiments, confirmed SiO2@PDA/Fe3+@Cis@HM efficiently killed as well HVECs. endogenous exosomes damaged HVECs induced anti-tumor M1 macrophage polarization indirectly kill achieve synergistic therapy. This immune regulation was completely inherent exhibited consistent efficacy, without ethical connotations. In conclusion, this strategy first adopt cell/vascular double-targeted concept, which realized direct natural enhancement response could become new paradigm for osteosarcoma.

Language: Английский

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Macrophage heterogeneity in bone metastasis

Journal of bone oncology, Journal Year: 2024, Volume and Issue: 45, P. 100598 - 100598

Published: March 21, 2024

Previous studies illustrated that macrophage, a type of innate immune cells, plays critical roles in tumour progression and metastasis. Bone is the most frequent site metastasis for several cancer types including breast, prostate, lung. In bone metastasis, osteoclast, macrophage subset specialized resorption, was heavily investigated past. Recent other subsets, e.g. monocyte-derived macrophages resident macrophages, promoted independent osteoclast function. These novel mechanisms further improved our understanding heterogeneity context new opportunities future studies.

Language: Английский

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Long non-coding RNAs in bone metastasis: progresses and perspectives as potential diagnostic and prognostic biomarkers

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: April 17, 2023

In a precision medicine perspective, among the biomarkers potentially useful for early diagnosis of cancers, as well to define their prognosis and eventually identify novel more effective therapeutic targets, there are long non-coding RNAs (lncRNAs). The term lncRNA identifies class RNA molecules involved in regulation gene expression that intervene at transcriptional, post-transcriptional, epigenetic level. Metastasis is natural evolution some malignant tumours, frequently encountered patients with advanced cancers. Onset development metastasis represents detrimental event worsen patient's by profoundly influencing quality life responsible ominous progression disease. Due peculiar environment biomechanical properties, bone preferential site secondary growth breast, prostate lung Unfortunately, only palliative pain therapies currently available metastases, while no definitive treatments available. understanding pathophysiological basis formation progression, improvement clinical management patient, central but challenging topics basic research practice. identification new molecular species may have role hallmarks metastatic process could open door definition new, effective, diagnostic approaches. Non-coding and, particularly, lncRNAs promising compounds this setting, study bring relevant processes. review, we highlight emerging mediating possible cancer prognosis, targets counteract spread.

Language: Английский

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