Peer Review #3 of "Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma (v0.1)" DOI Creative Commons

Published: Dec. 19, 2022

Background: Ferroptosis is a new type of iron-and reactive oxygen species-dependent cell death, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear renal carcinoma (ccRCC) are limited.The purpose this study was to investigate the potential prognostic value FerLncRNAs and their relationship with immune microenvironment immunotherapy response ccRCC.Methods: RNA sequencing data 526 patients ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database.The TCGA randomly divided (1:1) into training testing cohort.ICGC GEO databases used for validation.Screening performed using Pearson's correlation analysis reported genes.A FerLncRNA signature constructed univariate, LASSO, multivariate Cox regression analyses cohort.Internal external datasets verify FRlncRNA signature.Four major FRlncRNAs verified through vitro experiment.Results: We identified seven (LINC00894, DUXAP8, LINC01426, PVT1, PELATON, LINC02609, MYG1-AS1), established risk nomogram predicting prognosis ccRCC.Four GEPIA K-M Plotter databases, expressions validated by realtime PCR.The can also effectively reflect environment, drug sensitivity ccRCC.These have great significance implementation individualized treatment disease monitoring patients.

Language: Английский

Application prospects of ferroptosis in colorectal cancer DOI Creative Commons

Gen Yang,

Biyun Qian, Liya He

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Colorectal cancer (CRC) is a serious threat to human health with the third morbidity and second cancer-related mortality worldwide. It urgent explore more effective strategy for CRC because of acquired treatment resistance from non-surgical conventional therapies, including radiation, chemotherapy, targeted therapy immunotherapy. Ferroptosis novel form programmed cell death characterized by iron-dependent lipid peroxidation species (ROS) accumulation has been identified as promising target treatment, especially those resistance. In this review, we mainly summarize recent studies on influence regulation ferroptosis which (including gut microbiota) modulating metabolism iron, amino acid lipid. Thus analysis may provide potential targets inducing shed lights future application in CRC.

Language: Английский

Citations

0
Noncoding RNAs in cancer ferroptosis: From biology to clinical opportunity DOI Creative Commons
Chan Shan, Yan Liang, Kun Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115053 - 115053

Published: June 28, 2023

Ferroptosis is a recently discovered pattern of programmed cell death that nonapoptotic and irondependent. It involved in lipid peroxidation dependent on reactive oxygen species. has been verified to play crucial regulatory role variety pathological courses disease, particularly cancer. Emerging research highlighted the potential ferroptosis tumorigenesis, cancer development resistance chemotherapy. However, mechanism remains unclear, which limits application treatment. Noncoding RNAs (ncRNAs) are noncoding transcripts regulate gene expression various ways affect malignant phenotypes cells. At present, biological function underlying ncRNAs have partially elucidated. Herein, we summarize current knowledge central network ferroptosis, with focus functions ferroptosis. The clinical prospects ferroptosis-related diagnosis, prognosis anticancer therapies also discussed. Elucidating along assessing significance ncRNAs, provides new perspectives for understanding biology treatment approaches, may benefit numerous patients future.

Language: Английский

Citations

7
Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway DOI
Yanfang Liu, Yan Wang, Bing Liu

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 67(4), P. 663 - 679

Published: Dec. 19, 2023

Language: Английский

Citations

7
Advances in understanding the role of lncRNA in ferroptosis DOI Creative Commons
Yating Wen,

Wenbo Lei,

Jie Zhang

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17933 - e17933

Published: Aug. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Language: Английский

Citations

2
A novel neutrophil extracellular traps-related lncRNA signature predicts prognosis in patients with early-stage lung adenocarcinoma DOI Creative Commons
Huan Wang, Yueli Shi,

Xia Xu

et al.

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(2)

Published: Nov. 19, 2023

Background Neutrophil extracellular traps (NETs) could entrap tumour cells and promote their dissemination metastasis. Further analysis of NETs-related molecules is expected to provide a new strategy for prognosis prediction treatment lung adenocarcinoma (LUAD) patients.

Language: Английский

Citations

4
Transcriptome Study of 2 Black Cohorts Reveals cis Long Noncoding RNAs Associated With Hypertension‐Related mRNAs DOI Creative Commons
Malak Abbas, Gabriel Goodney, Jose D. Vargas

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(11)

Published: May 31, 2024

Background Long noncoding RNAs (lncRNAs) have emerged as critical regulators of the expression genes involved in cardiovascular diseases. This project aims to identify circulating lncRNAs associated with protein‐coding mRNAs differentially expressed between hypertensive and normotensive individuals establish their link hypertension. Methods Results The analyses were conducted 3 main steps: (1) an unbiased whole blood transcriptome‐wide analysis was replicate by hypertension status 497 179 Black from GENE‐FORECAST (Genomics, Environmental Factors Social Determinants Cardiovascular Disease African‐Americans Study) MH‐GRID (Minority Health Genomics Translational Research Bio‐Repository Database) studies, respectively. Subsequently, (2) proximal lncRNAs, termed cis lncRNA quantitative trait loci, each mRNA identified study replicated study. Finally, (3) loci used predictors a random forest model predict both data sets. A total 129 significantly lncRNA‐mRNA association revealed 249 102 mRNAs, including VAMP2 (vesicle‐associated membrane protein 2), mitogen‐activated kinase 3, CCAAT enhancer binding beta, lymphocyte antigen 6 complex, locus E. predicted area under curve 0.79 0.71 Conclusions leveraged significant sample individuals, population facing disproportionate burden unveiled 271 relationships involving that play roles vascular pathways relevant pressure regulation. compelling findings, consistent across 2 independent sets, reliable foundation for designing vitro/in vivo experiments.

Language: Английский

Citations

1
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer DOI
Lin Yan, Lili Kong, Yiting Zhao

et al.

Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

Citations

1
Comprehensive Analysis Identifies Ameloblastin-Related Competitive Endogenous RNA as a Prognostic Biomarker for Testicular Germ Cell Tumour DOI Open Access
Tianxiang Geng, Catherine A. Heyward, Xi Chen

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(8), P. 1870 - 1870

Published: April 7, 2022

Testicular Germ Cell Tumour (TGCT) is one of the most common tumours in young men. Increasing evidence shows that extracellular matrix has a key role prognosis and metastasis various human cancers. This study analysed relationship between protein ameloblastin (AMBN) potential biological markers associated with TGCT diagnosis prognosis. The AMBN was determined by bioinformatic analysis using expression profiles three RNAs (long non-coding (lncRNAs), microRNAs (miRNAs) mRNAs) from Cancer Genome Atlas (TCGA) database, available clinical information corresponding patients. Prediction validation competitive endogenous RNA (ceRNA) regulatory networks related to performed. its ceRNA network were found be recurrence TGCT, LINC02701 may used as diagnostic factor TGCT. Furthermore, we identified PELATON (Plaque Enriched LncRNA In Atherosclerotic And Inflammatory Bowel Macrophage Regulation) an independent prognostic for progression-free interval.

Language: Английский

Citations

5
Systematic discrimination of the repetitive genome in proximity of ferroptosis genes and a novel prognostic signature correlating with the oncogenic lncRNA CRNDE in multiple myeloma DOI Creative Commons
Jiading Qin, Amit Sharma, Yulu Wang

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 20, 2022

Emerging insights into iron-dependent form of regulated cell death ferroptosis in cancer have opened a perspective for its use therapy. Of interest, systematic profiling gene signatures as prognostic factors has gained special attention several cancers. Herein, we sought to investigate the presence repetitive genomes vicinity genes that may influence their expression and establish signature associated with multiple myeloma (MM). Our analysis showed were enriched genome vicinity, strong predominance SINE family, followed by LINE, which most significant discriminant values SINE/Alu LINE/L1, respectively. In addition, examined detail performance these risk prediction model specified fourteen ferroptosis-related signatures, identified MM high-risk patients lower immune/stromal scores higher tumor purity immune microenvironment. also found lncRNA CRNDE correlated score was highly majority comprising signature. Taken together, propose molecular impact highlighted on local transcriptome cancer. Furthermore, revealed genomic signature/biomarker related can be used predict survival patients.

Language: Английский

Citations

5
Identification of a ferroptosis-related prognostic signature and validation of ITGA6-AS1 in enhancing cell proliferation, migration and invasion in glioma DOI

Minli Jiang,

Yu Liu, Tingting Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112438 - 112438

Published: June 13, 2024

Language: Английский

Citations

0