Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(11), P. 1623 - 1642
Published: Nov. 2, 2023
Tumors pose a significant global economic and health burden, with conventional cancer treatments lacking tumor specificity, leading to limited efficiency undesirable side effects. Targeted therapy is imminent. Tumor cells produce lactate hydrogen ions (H
Language: Английский
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329
Published: Aug. 5, 2024
Language: Английский
Citations
8
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103306 - 103306
Published: Oct. 5, 2024
Chronic wounds are a critical and costly complication that affects millions of patients each year, especially suffering from diabetes, constitute serious global healthcare problem needs immediate attention. In this direction, novel dressings can integrate appropriate physicochemical biological features, mechanical durability, the capacity for therapy great clinical importance. For instance, self-healable hydrogels, with antibacterial activity high tissue adhesion, have attracted increasing attention wound management applications. Despite their potential, existing hydrogel networks exhibit limitations in strength regeneration, efficacy, scalability, indicating need further improvement field. This review focuses on exactly these recent advances field special focus self-healing adhesive hydrogel-based as well structures, construction strategies, adhesion mechanisms, emerging usage healing By shedding light developments, we aim to contribute ongoing pursuit enhanced solutions chronic care.
Language: Английский
Citations
7
Journal of Peptide Science, Journal Year: 2024, Volume and Issue: 30(7)
Published: Feb. 21, 2024
Targeted cancer treatment should avoid side effects and damage to healthy cells commonly encountered during traditional chemotherapy. By combining small molecule or peptidic ligands as homing devices with cytotoxic drugs connected by a cleavable non‐cleavable linker in peptide–drug conjugates (PDCs) molecule–drug (SMDCs), tumours can be selectively targeted. The development of highly affine, selective peptides molecules recent years has allowed PDCs SMDCs increasingly compete antibody‐drug (ADCs). Integrins represent an excellent target for because they are overexpressed most the broad knowledge about native binding partners well multitude small‐molecule that have been developed over last 30 years. In particular, integrin α V β 3 addressed using variety different two decades, following various strategies. This review summarises describes integrin‐addressing while highlighting points great interest.
Language: Английский
Citations
6
Small, Journal Year: 2024, Volume and Issue: 21(1)
Published: Oct. 23, 2024
Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.
Language: Английский
Citations
6
Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(11), P. 1623 - 1642
Published: Nov. 2, 2023
Tumors pose a significant global economic and health burden, with conventional cancer treatments lacking tumor specificity, leading to limited efficiency undesirable side effects. Targeted therapy is imminent. Tumor cells produce lactate hydrogen ions (H
Language: Английский
Citations
16