Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 8, 2024
Osteosarcoma,
a
highly
aggressive
malignant
bone
tumor,
is
significantly
influenced
by
the
intricate
interactions
within
its
tumor
microenvironment
(TME),
particularly
involving
neutrophils.
This
review
delineates
multifaceted
roles
of
neutrophils,
including
tumor-associated
neutrophils
(TANs)
and
neutrophil
extracellular
traps
(NETs),
in
osteosarcoma’s
pathogenesis.
TANs
exhibit
both
pro-
anti-tumor
phenotypes,
modulating
growth
immune
evasion,
while
NETs
facilitate
cell
adhesion,
migration,
immunosuppression.
Clinically,
neutrophil-related
markers
such
as
neutrophil-to-lymphocyte
ratio
(NLR)
predict
patient
outcomes,
highlighting
potential
for
neutrophil-targeted
therapies.
Unraveling
these
complex
crucial
developing
novel
treatment
strategies
that
harness
TME
to
improve
osteosarcoma
management.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(3), P. 368 - 368
Published: Jan. 23, 2025
Fusobacterium
nucleatum,
a
gram-negative
anaerobic
bacterium,
has
emerged
as
significant
player
in
colorectal
cancer
(CRC)
pathogenesis.
The
bacterium
causes
persistent
inflammatory
reaction
the
mucosa
by
stimulating
release
of
pro-inflammatory
cytokines
like
IL-1β,
IL-6,
and
TNF-α,
creating
an
environment
conducive
to
progression.
F.
nucleatum
binds
penetrates
epithelial
cells
through
adhesins
such
FadA,
impairing
cell
junctions
encouraging
epithelial-to-mesenchymal
transition
(EMT),
which
is
associated
with
advancement.
Additionally,
modulates
host
immune
system,
suppressing
activity
conditions
favorable
for
tumor
growth.
Its
interactions
gut
microbiome
contribute
dysbiosis,
further
influencing
carcinogenic
pathways.
Evidence
indicates
that
can
inflict
DNA
damage
either
directly
via
reactive
oxygen
species
or
indirectly
environment.
it
triggers
oncogenic
pathways,
especially
Wnt/β-catenin
signaling
pathway,
promotes
growth
longevity.
Moreover,
alters
microenvironment,
impacting
behavior,
metastasis,
therapeutic
responses.
purpose
this
review
elucidate
molecular
mechanisms
contributes
CRC.
Understanding
these
crucial
development
targeted
therapies
diagnostic
strategies
CRC
nucleatum.
Military Medical Research,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Feb. 11, 2025
Abstract
Cancer
recurrence,
driven
by
the
phenomenon
of
tumor
dormancy,
presents
a
formidable
challenge
in
oncology.
Dormant
cancer
cells
have
ability
to
evade
detection
and
treatment,
leading
relapse.
This
review
emphasizes
urgent
need
comprehend
dormancy
its
implications
for
recurrence.
Despite
notable
advancements,
significant
gaps
remain
our
understanding
mechanisms
underlying
lack
reliable
biomarkers
predicting
provides
comprehensive
analysis
cellular,
angiogenic,
immunological
aspects
dormancy.
It
highlights
current
therapeutic
strategies
targeting
dormant
cells,
particularly
combination
therapies
immunotherapies,
which
hold
promise
preventing
By
elucidating
these
proposing
innovative
research
methodologies,
this
aims
deepen
ultimately
facilitating
development
more
effective
recurrence
improving
patient
outcomes.
International Journal of Oncology,
Journal Year:
2022,
Volume and Issue:
62(2)
Published: Dec. 27, 2022
Genetic
alterations
drive
tumor
onset
and
progression.
However,
the
cross‑talk
between
cells
benign
components
of
surrounding
stroma
can
also
promote
initiation,
progression
metastasis
solid
tumors.
These
cellular
non‑cellular
stromal
form
microenvironment
(TME),
which
co‑evolves
with
cells.
Their
dynamic
mutualistic
interactions
are
currently
considered
to
be
among
distinctive
hallmarks
cancer.
Biochemical
physical
cues
from
TME
serve
an
essential
role
in
regulating
They
associated
resistance
treatment
poor
prognosis
patients
Therefore,
a
deep
understanding
is
vital
for
developing
potent
anticancer
therapeutics
improving
patient
outcomes.
The
present
review
aims
biology
both
constituents
novel
findings
regarding
their
contribution
core
as
well
emerging
cancer
hallmarks.
describes
key
markers
that
either
targeted
interventional
clinical
trials
or
promising
potential
therapies.
Understanding
intercellular
toward
identifying
mechanisms
resistance.
Such
utmost
significance
personalized
effective
therapy
strategies.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: July 10, 2023
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
deadliest
subtypes
(BC)
for
its
high
aggressiveness,
heterogeneity,
and
hypoxic
nature.
Based
on
biological
clinical
observations
TNBC
related
mortality
very
worldwide.
Emerging
studies
have
clearly
demonstrated
that
hypoxia
regulates
critical
metabolic,
developmental,
survival
pathways
in
TNBC,
which
include
glycolysis
angiogenesis.
Alterations
to
these
accelerate
stem
cells
(CSCs)
enrichment
immune
escape,
further
lead
tumor
invasion,
migration,
metastasis.
Beside
this,
also
manipulates
epigenetic
plasticity
DNA
damage
response
(DDR)
syndicate
progression.
Hypoxia
fundamentally
creates
low
oxygen
condition
responsible
alteration
Hypoxia-Inducible
Factor-1alpha
(HIF-1α)
signaling
within
microenvironment,
allowing
tumors
survive
making
them
resistant
various
therapies.
Therefore,
there
an
urgent
need
society
establish
target-based
therapies
overcome
resistance
limitations
current
treatment
plan
TNBC.
In
this
review
article,
we
thoroughly
discussed
plausible
significance
HIF-1α
as
a
target
therapeutic
regimens
such
chemotherapy,
radiotherapy,
immunotherapy,
anti-angiogenic
therapy,
adjuvant
therapy
photodynamic
adoptive
cell
combination
therapies,
antibody
drug
conjugates
vaccines.
Further,
reviewed
here
intrinsic
mechanism
existing
issues
targeting
while
improvising
strategies.
This
highlights
discusses
future
perspectives
major
alternatives
by
hypoxia-induced
signaling.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 15, 2023
Abstract
The
pivotal
role
of
the
tumor
microenvironment
(TME)
in
initiation
and
advancement
hepatocellular
carcinoma
(HCC)
is
widely
acknowledged,
as
it
fosters
proliferation
metastasis
HCC
cells.
Within
intricate
TME
HCC,
tumor-associated
macrophages
(TAMs)
represent
a
significant
constituent
non-malignant
TAMs
engage
direct
communication
with
cancer
cells
while
also
exerting
influence
on
other
immune
to
adopt
tumor-supportive
phenotype
that
facilitates
progression.
Among
multifaceted
mechanisms
at
play,
metabolic
reprogramming
both
leads
phenotypic
alterations
functional
modifications
macrophages.
This
comprehensive
review
elucidates
interplay
between
cellular
metabolism
macrophage
phenotype/polarization,
providing
an
overview
associated
signaling
molecules
potential
therapeutic
strategies
for
HCC.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15827 - 15827
Published: Dec. 13, 2022
Neutrophils
represent
the
most
abundant
cell
type
of
leukocytes
in
human
blood
and
have
been
considered
a
vital
player
innate
immune
system
first
line
defense
against
invading
pathogens.
Recently,
several
studies
showed
that
neutrophils
play
an
active
role
response
during
cancer
development.
They
exhibited
both
pro-oncogenic
anti-tumor
activities
under
influence
various
mediators
tumor
microenvironment.
can
be
divided
into
subpopulations,
thus
contradicting
traditional
concept
as
homogeneous
population
with
specific
function
immunity
opening
new
horizons
for
therapy.
Despite
promising
achievements
this
field,
full
understanding
tumor–neutrophil
interplay
is
currently
lacking.
In
review,
we
try
to
summarize
current
view
on
neutrophil
heterogeneity
cancer,
discuss
different
communication
pathways
between
tumors
neutrophils,
focus
implementation
these
findings
develop
neutrophil-based
therapies.
Cancer Cell International,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: July 5, 2022
Abstract
Bioactive
lipid
molecules
have
been
proposed
to
play
important
roles
linking
obesity/metabolic
syndrome
and
cancers.
Studies
reveal
that
aberrant
metabolic
signaling
can
reprogram
cancer
cells
non-cancer
in
the
tumor
microenvironment,
contributing
initiation,
progression,
metastasis,
recurrence,
poor
therapeutic
response.
Existing
evidence
indicates
controlling
metabolism
be
a
potential
strategy
for
prevention
therapy.
By
reviewing
current
literature
on
various
cancers,
we
summarized
major
including
fatty
acids
cholesterol
as
well
droplets
discussed
their
critical
terms
of
either
promoting-
or
anti-tumorigenesis.
This
review
provides
an
overview
cellular
entities
adding
existing
knowledge
with
reprogramming
immune
associated
cells.
Comprehensive
understanding
regulatory
role
microenvironment
will
provide
new
direction
further
studies,
shift
away
from
conventional
research.
Exploring
lipid-related
targets
drive
block
development
may
lead
novel
anti-cancer
strategies
distinct
traditional
approaches
treatment.
European journal of medical research,
Journal Year:
2023,
Volume and Issue:
28(1)
Published: Sept. 7, 2023
Cervical
cancer
the
fourth
most
frequently
diagnosed
and
leading
cause
of
death
in
women,
with
an
estimated
604,000
new
cases
342,000
deaths
worldwide
2020
for
high
rates
recurrence
metastasis.
Identification
novel
targets
could
aid
prediction
treatment
cervical
cancer.
NADPH
oxidase
1
(NOX1)
gene-mediated
production
reactive
oxygen
species
(ROS)
induce
migration
invasion
cells.
Tumor-associated
macrophages
(TAMs)
play
important
roles
Tumor
cell-derived
exosomes
mediate
signal
transduction
between
tumor
microenvironment.
Elucidation
mechanisms
NOX1-carrying
involved
regulation
TAMs
may
provide
valuable
insights
into
progression
cancer.Uniformly
standardized
mRNA
data
pan-carcinoma
from
UCSC
database
were
downloaded.
Expression
NOX1
adjacent
normal
tissues
each
type
was
calculated
using
R
language
software
significant
differences
analyzed.
SNP
set
downloaded
all
TCGA
samples
processed
MuTect2
GDC.
Cell
experiment
animal
formation
used
to
evaluate
whether
exosomal
stimulating
ROS
promote
M2
polarization
TAM
cancer.NOX1
is
highly
expressed
a
low
mutational
frequency
pan-carcinoma.
Upregulation
be
associated
infiltration
M2-type
tissues,
promotes
malignant
features
cells
by
production.
Exosomal
enhances
vivo
production.Exosomal
polarization-mediated
through
