APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(5-6), P. 835 - 848
Published: April 4, 2024
Language: Английский
Cancer Letters, Journal Year: 2023, Volume and Issue: 559, P. 216119 - 216119
Published: March 7, 2023
Language: Английский
Citations
61
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 3, 2024
Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture intracellular content release. Originally investigated as targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential complement chemotherapy, immunotherapy, radiotherapy in various types. However, it can lead side effects, including immune death, bone marrow impairment, liver kidney damage, cachexia (severe weight loss muscle wasting), secondary tumorigenesis. In this review, we discuss the advantages offer an overview diverse range documented effects. Furthermore, examine underlying mechanisms explore strategies effect mitigation.
Language: Английский
Citations
31
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155907 - 155907
Published: March 12, 2025
Language: Английский
Citations
2
Hepatology, Journal Year: 2023, Volume and Issue: 80(3), P. 721 - 739
Published: April 4, 2023
The most widespread type of liver cancer, HCC, is associated with disabled cellular death pathways. Despite therapeutic advancements, resistance to current systemic treatments (including sorafenib) compromises the prognosis patients driving search for agents that might target novel cell Ferroptosis, a form iron-mediated nonapoptotic death, has gained considerable attention as potential cancer therapy, especially in HCC. role ferroptosis HCC complex and diverse. On one hand, can contribute progression through its involvement both acute chronic conditions. In contrast, having affect cells be desirable. This review examines from cellular, animal, human perspectives while examining mechanisms, regulation, biomarkers, clinical implications.
Language: Английский
Citations
31
Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216147 - 216147
Published: March 24, 2023
Language: Английский
Citations
26
Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155220 - 155220
Published: Nov. 18, 2023
Language: Английский
Citations
24
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Aug. 27, 2024
Abstract The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, unique type regulated cell death, plays pivotal role inhibiting tumour growth, presenting new opportunities treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine vulnerability to ferroptosis. In this review, we first summarize the growth/development. Then, core molecular mechanisms ferroptosis, its upstream regulation, and downstream effects on Finally, review recent advances understanding how ncRNAs regulate ferroptosis from such modulate This aims enhance general ncRNA-mediated regulatory which highlighting ncRNA-ferroptosis axis as key druggable target overcoming
Language: Английский
Citations
15
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(9), P. 3621 - 3637
Published: Jan. 1, 2024
Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane rupture death. Many canonical signalling pathways biological processes are involved in ferroptosis. Furthermore, cancer cells more susceptible ferroptosis due the high load ROS unique metabolic characteristics, including iron requirements. Recent investigations have revealed that plays a crucial role progression tumours, especially HCC. Specifically, induction can not only inhibit growth hepatoma cells, thereby reversing tumorigenesis, but also improves efficacy immunotherapy enhances antitumour immune response. Therefore, triggering has become new therapeutic strategy for therapy. In this review, we summarize characteristics based on its underlying mechanism HCC provide possible applications.
Language: Английский
Citations
12
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234
Published: May 20, 2024
Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.
Language: Английский
Citations
10
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related
Language: Английский
Citations
10