Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 3, 2025
Aberrant
lipid
metabolism
is
a
well-recognized
hallmark
of
cancer.
Notably,
breast
cancer
(BC)
arises
from
lipid-rich
microenvironment
and
depends
significantly
on
metabolic
reprogramming
to
fulfill
its
developmental
requirements.
In
this
review,
we
revisit
the
pivotal
role
in
BC,
underscoring
impact
progression
tumor
microenvironment.
Firstly,
delineate
overall
landscape
highlighting
roles
patient
prognosis.
Given
that
lipids
can
also
act
as
signaling
molecules,
next
describe
exchanges
between
BC
cells
other
cellular
components
Additionally,
summarize
therapeutic
potential
targeting
aspects
processes,
lipid-related
transcription
factors
immunotherapy
BC.
Finally,
discuss
possibilities
problems
associated
with
clinical
applications
lipid‑targeted
therapy
propose
new
research
directions
advances
spatiotemporal
multi-omics.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
168, P. 115670 - 115670
Published: Oct. 13, 2023
Diabetic
nephropathy
(DN)
is
a
severe
complication
of
diabetes
mellitus,
posing
significant
challenges
in
terms
early
prevention,
clinical
diagnosis,
and
treatment.
Consequently,
it
has
emerged
as
major
contributor
to
end-stage
renal
disease.
The
glomerular
filtration
barrier,
composed
podocytes,
endothelial
cells,
the
basement
membrane,
plays
vital
role
maintaining
function.
Disruptions
podocyte
function,
including
hypertrophy,
shedding,
reduced
density,
apoptosis,
can
impair
integrity
resulting
elevated
proteinuria,
abnormal
rate,
increased
creatinine
levels.
Hence,
recent
research
increasingly
focused
on
injury
DN,
with
growing
emphasis
exploring
therapeutic
interventions
targeting
injury.
Studies
have
revealed
that
factors
such
lipotoxicity,
hemodynamic
abnormalities,
oxidative
stress,
mitochondrial
dysfunction,
impaired
autophagy
contribute
This
review
aims
summarize
underlying
mechanisms
DN
provide
an
overview
current
status
regarding
experimental
drugs
DN.
findings
presented
herein
may
offer
potential
targets
strategies
for
management
associated
Cancer and Metastasis Reviews,
Journal Year:
2023,
Volume and Issue:
43(2), P. 673 - 708
Published: Dec. 1, 2023
Abstract
Hepatocellular
carcinoma
(HCC)
is
an
increasing
burden
on
global
public
health
and
associated
with
enhanced
lipogenesis,
fatty
acid
uptake,
lipid
metabolic
reprogramming.
De
novo
lipogenesis
under
the
control
of
transcription
factor
sterol
regulatory
element-binding
protein
1
(SREBP-1)
essentially
contributes
to
HCC
progression.
Here,
we
summarize
current
knowledge
regulation
SREBP-1
isoforms
in
based
cellular,
animal,
clinical
data.
Specifically,
(i)
address
overarching
mechanisms
for
regulating
transcription,
proteolytic
processing,
nuclear
stability,
transactivation
(ii)
critically
discuss
their
impact
HCC,
taking
into
account
(iii)
insights
from
pharmacological
approaches.
Emphasis
placed
cross-talk
phosphatidylinositol-3-kinase
(PI3K)-protein
kinase
B
(Akt)-mechanistic
target
rapamycin
(mTOR)
axis,
AMP-activated
(AMPK),
A
(PKA),
other
kinases
that
directly
phosphorylate
SREBP-1;
factors,
such
as
liver
X
receptor
(LXR),
peroxisome
proliferator-activated
receptors
(PPARs),
γ
co-activator
(PGC-1),
signal
transducers
activators
(STATs),
Myc;
epigenetic
mechanisms;
post-translational
modifications
SREBP-1-regulatory
metabolites
oxysterols
polyunsaturated
acids.
By
carefully
scrutinizing
role
development,
progression,
metastasis,
therapy
resistance,
shed
light
potential
SREBP-1-targeting
strategies
prevention
treatment.
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(7)
Published: March 27, 2025
ABSTRACT
Background
Within
the
tumor
microenvironment,
cells
undergo
metabolic
reprogramming
of
cholesterol
due
to
intrinsic
cellular
alterations
and
changes
in
extracellular
milieu.
Furthermore,
within
this
microenvironment
influences
immune
landscape
tumors,
facilitating
evasion
consequently
promoting
tumorigenesis.
These
biological
involve
modifications
numerous
enzymes
associated
with
uptake
synthesis,
including
NPC1L1,
SREBP,
HMGCR,
SQLE,
PCSK9.
Review
This
review
systematically
summarizes
role
metabolism
its
cancer
progression,
examines
mechanisms
through
which
dysregulation
affects
discusses
recent
advancements
therapies
that
target
metabolism.
Conclusion
Targeting
metabolism‐related
can
inhibit
growth,
reshape
landscapes,
rejuvenate
antitumor
immunity,
offering
potential
therapeutic
avenues
treatment.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3948 - 3948
Published: Aug. 3, 2023
Statins,
a
class
of
HMG-CoA
reductase
inhibitors
best
known
for
their
cholesterol-reducing
and
cardiovascular
protective
activity,
have
also
demonstrated
promise
in
cancer
prevention
treatment.
This
review
focuses
on
potential
applications
head
neck
(HNC),
common
malignancy
which
established
treatment
often
fails
despite
incurring
debilitating
adverse
effects.
Preclinical
clinical
studies
suggested
that
statins
may
enhance
HNC
sensitivity
to
radiation
other
conventional
therapies
while
protecting
normal
tissue,
but
the
underlying
mechanisms
remain
poorly
defined,
likely
involving
both
cholesterol-dependent
-independent
effects
diverse
cancer-related
pathways.
brings
together
recent
discoveries
concerning
anticancer
activity
relevant
HNC,
highlighting
anti-inflammatory
impacts
DNA-damage
response.
We
explore
molecular
targets
discuss
integrate
into
regimens
improve
patient
outcomes.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(5), P. 2036 - 2050
Published: Feb. 7, 2023
Abstract
Gastrointestinal
cancer
(GIC),
including
gastric
and
colorectal
cancer,
is
a
common
malignant
tumor
originating
from
gastrointestinal
epithelial
cells.
Although
the
pathogenesis
of
GIC
remains
unclear,
aberrant
lipid
metabolism
has
emerged
as
hallmark
cancer.
Several
enzymes,
proteins,
transcription
factors
are
involved
in
reprogramming
GIC,
their
abnormal
expression
can
promote
synthesis
accumulation
droplets
through
numerous
mechanisms,
thereby
affecting
growth,
proliferation,
metastasis
Studies
show
that
some
natural
compounds,
flavonoids,
alkaloids,
saponins,
inhibit
de
novo
lipids
reduce
level
accumulation,
subsequently,
occurrence
development
by
regulating
Sterol
regulatory
element‐binding
protein
1
(SREBP‐1),
adenosine
monophosphate‐activated
kinase
(AMPK),
3‐hydroxy‐3‐methylglutaryl‐coenzyme
A
reductase
(HMGCR),
phosphatidylinositol‐3‐kinase/Akt
mammalian
target
rapamycin
PI3K/Akt/mTOR,
amongst
other
targets
pathways.
Therefore,
targeting
focus
anti‐gastrointestinal
therapy.
most
products
require
further
high‐quality
studies
to
firmly
establish
clinical
efficacy,
we
review
potential
treatment
summarize
application
prospect
new
for
hoping
provide
reference
drug
tumors.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114981 - 114981
Published: June 7, 2023
Lipid
metabolism
disorders
are
pivotal
in
the
development
of
various
lipid-related
diseases,
such
as
obesity,
atherosclerosis,
non-alcoholic
fatty
liver
disease,
type
2
diabetes,
and
cancer.
Celastrol,
a
bioactive
compound
extracted
from
Chinese
herb
Tripterygium
wilfordii
Hook
F,
has
recently
demonstrated
potent
lipid-regulating
abilities
promising
therapeutic
effects
for
diseases.
There
is
substantial
evidence
indicating
that
celastrol
can
ameliorate
lipid
by
regulating
profiles
related
metabolic
processes,
including
synthesis,
catabolism,
absorption,
transport,
peroxidation.
Even
wild-type
mice
show
augmented
after
treatment
with
celastrol.
This
review
aims
to
provide
an
overview
recent
advancements
properties
celastrol,
well
elucidate
its
underlying
molecular
mechanisms.
Besides,
potential
strategies
targeted
drug
delivery
combination
therapy
proposed
enhance
avoid
limitations
clinical
application.
Lipids in Health and Disease,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Aug. 3, 2023
Abstract
Glioblastoma
(GBM)
is
a
highly
aggressive
and
lethal
brain
tumor
with
limited
treatment
options,
such
as
the
chemotherapeutic
agent,
temozolomide
(TMZ).
However,
many
GBM
tumors
develop
resistance
to
TMZ,
which
major
obstacle
effective
therapy.
Recently,
dysregulated
lipid
metabolism
has
emerged
an
important
factor
contributing
TMZ
in
GBM.
The
dysregulation
of
hallmark
cancer
alterations
have
been
linked
multiple
aspects
biology,
including
proliferation,
migration,
In
this
review,
we
aimed
summarize
current
knowledge
on
TMZ-resistant
GBM,
key
metabolites
proteins
involved
synthesis,
uptake,
utilization,
recent
advances
application
metabolomics
study
We
also
discussed
potential
target
for
novel
therapeutic
interventions.
Finally,
highlighted
challenges
opportunities
associated
developing
these
interventions
clinical
use,
need
further
research
fully
understand
role
Our
review
suggests
that
targeting
may
be
promising
approach
overcome
improve
outcomes
patients
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: May 15, 2023
The
immune
function
of
normal
T
cells
partially
depends
on
the
maneuvering
lipid
metabolism
through
various
stages
and
subsets.
Interestingly,
T-cell
malignancies
also
reprogram
their
to
fulfill
bioenergetic
demand
for
rapid
division.
rewiring
in
not
only
provides
survival
benefits
but
contributes
stemness,
invasion,
metastasis,
angiogenesis.
Owing
distinctive
metabolic
programming
cancer,
quantitative,
qualitative,
spatial
enrichment
specific
molecules
occur.
formation
rafts
rich
cholesterol
confers
physical
strength
sustains
signals.
accumulation
lipids
de
novo
synthesis
uptake
free
contribute
reserve
required
robust
during
migration
metastasis.
Lipid
storage
leads
specialized
structures
known
as
droplets.
inimitable
changes
fatty
acid
(FAS)
oxidation
(FAO)
are
dynamic
balance
malignancies.
FAO
fuels
molecular
pumps
causing
chemoresistance,
while
FAS
offers
structural
signaling
cancer
having
immunosuppressive
abilities.
Moreover,
composition
membrane
has
implications
evasion
by
malignant
origin.
droplets
contributors
maintaining
hallmarks
cells.
In
preclinical
settings,
targeting
potentiates
antitumor
immunity
chemotherapeutic
response.
Thus,
direct
adjunct
benefit
is
expected
improve
clinical
management
