Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer DOI Creative Commons
Danfeng Lan, Junyu Wang,

Guishun Sun

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 16, 2024

Abstract Colorectal cancer (CRC), a digestive tract malignancy with high mortality and morbidity, lacks effective biomarkers for clinical prognosis due to its complex molecular pathogenesis. Nucleotide binding protein 2 (NUBP2) plays vital role in the assembly of cytosolic Fe/S has been implicated progression. In this study, we found that NUBP2 was highly expressed CRC by TCGA database analysis. Subsequently, verified expression tumor tissues para-carcinoma using IHC staining, further investigated association clinicopathological parameters. vitro cell experiments were conducted assess evaluating proliferation, migration, apoptosis upon dysregulation. Furthermore, established subcutaneous model evaluate impact on growth vivo. Additionally, performed mechanistic exploration Human Phospho-Kinase Array-Membrane. Our results showed higher tissues, which positively correlated pathological stage, indicating involvement malignancy. Functional studies demonstrated knockdown reduced increased apoptosis, impaired migration ability. Moreover, inhibited mice. We also observed significant changes phosphorylation level GSK3β or overexpression. treatment CHIR-99021 HCl, an inhibitor GSK3β, reversed malignant phenotype induced Overall, study elucidated functional progression both vivo, providing insights into mechanisms underlying potential implications targeted therapeutic strategies.

Language: Английский

FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production DOI Creative Commons
Bo Sun, Peng Ding, Yinghui Song

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103302 - 103302

Published: Aug. 6, 2024

Mitochondrial dysfunction and metabolic reprogramming can lead to the development progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein recent studies have shown that FDX1 plays an important role in tumor cuproptosis, but its HCC still elusive. In this study, we aim investigate expression novel functions HCC.

Language: Английский

Citations

17
Immunomodulation of cuproptosis and ferroptosis in liver cancer DOI Creative Commons

Jia-qian Mo,

S. Zhang,

Qiang Li

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 10, 2024

Abstract According to statistics, the incidence of liver cancer is increasing yearly, and effective treatment imminent. For early cancer, resection surgery currently most treatment. However, does not treat disease in advanced patients, so finding a method with better prognosis necessary. In recent years, ferroptosis cuproptosis have been gradually defined, related studies proved that they show excellent results therapy cancer. Cuproptosis new form cell death, use combined inhibit production hepatocellular carcinoma cells has good development prospects worthy in-depth discussion by researchers. this review, we summarize research progress on treating analyze value immune propose potential pathways oncotherapy combination ferroptosis, which can provide background knowledge for subsequent research.

Language: Английский

Citations

13
Mechanisms of cuproptosis and its relevance to distinct diseases DOI

Qiao-mei Lou,

Feifan Lai,

Jingwei Li

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(7-8), P. 981 - 1006

Published: June 2, 2024

Language: Английский

Citations

11
Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma DOI Creative Commons
Meilin Li, Yu Bin Tan, Zhixin Li

et al.

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 11, 2025

Lung cancer has high morbidity and mortality rates, which results in a poor prognosis. Cuproptosis is novel cell death mechanism. The aim of this study was to examine the biological characteristics clinical significance genes associated with cuproptosis lung adenocarcinoma (LUAD), understand molecular mechanisms underlying occurrence progression LUAD. We targeted 10 cuproptosis-related from previous studies used datasets GEO TCGA databases identify differential related cuproptosis; then data were analyzed by R package, Cytoscape, TISDB, cBioPortal, STRING, CancerSEA, Disgenet; finally, detected immunohistochemistry validation performed. CDKN2A MTF1 cuproptosis-associated LUAD differentially expressed immune subtypes. expression showed correlation multiple functional states LUAD.CDKN2A negatively correlated survival diagnosis LUAD, prognosis potential contribute early analysis

Language: Английский

Citations

0
Cuproplasia and cuproptosis in hepatocellular carcinoma: mechanisms, relationship and potential role in tumor microenvironment and treatment DOI Creative Commons
Ruoyu Zhang, Yunfei Tan, Ke Xu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper vital in function, and HCC cells rely on it for growth metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis. Tumor microenvironment (TME) pivotal HCC, especially immunotherapy, closely related TME pathogenesis. However, how these two mechanisms contribute intriguing. We conducted latest progress literature cuproplasia cuproptosis summarized their specific roles treatment strategies. The relationship role have been deeply summarized. Cuproplasia fosters formation, angiogenesis, whereas may alleviate mitochondrial dysfunction hypoxic conditions TME. Inhibiting enhancing are essential achieving therapeutic efficacy HCC. An in-depth analysis within unveils opposing nature impact regulation. Grasping equilibrium between factors crucial deeper understanding shed light novel directions treating

Language: Английский

Citations

0
Systematic analysis of the prognostic potential and functional roles of mitochondrially encoded protein coding genes in glioma DOI

Pengying Mei

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100350 - 100350

Published: April 1, 2025

Language: Английский

Citations

0
Emerging roles of cuproptosis in liver diseases DOI Creative Commons
Qi Yang, Xiaohong Liu,

Huixin Tang

et al.

Digestive and Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Intracellular copper levels should be maintained within a controlled range to obtain homeostasis. Cuproptosis, newly discovered form of cell death, occurs when excessive ions bind the lipoylated enzymes in tricarboxylic acid cycle, which leads protein aggregation, proteotoxic stress, and ultimately death. Herein, we summarize current knowledge regarding metabolism, discovery molecular mechanism cuproptosis. In addition, discuss implications cuproptosis pathogenesis various liver diseases, including hepatocellular carcinoma (HCC), Wilson disease (WD), metabolic-associated fatty (MAFLD), fibrosis, hepatic ischemia-reperfusion injury (HIRI) drug-induced (DILI). Understanding can not only provide deeper insights into diseases but also open up new avenues for development targeted therapies.

Language: Английский

Citations

0
Role of DLAT in Cuproptosis and Autophagy in Hippocampal Tissue of PTSD Rats with High-Voltage Electrical Burns DOI Creative Commons

Chenyang Ge,

Xuegang Zhao,

Jing Zhang

et al.

Burns, Journal Year: 2025, Volume and Issue: unknown, P. 107519 - 107519

Published: April 1, 2025

Language: Английский

Citations

0
The mechanism of copper homeostasis and its role in disease DOI Creative Commons
Y. Li, Jing Liang, Yuan Chen

et al.

iLABMED, Journal Year: 2023, Volume and Issue: 1(2), P. 109 - 120

Published: Aug. 8, 2023

Abstract Copper (Cuprum) is an essential trace metal indispensable for the function of numerous enzymatic molecules implicated in cellular metabolism. Emerging evidence has demonstrated role copper angiogenesis and signaling. Moreover, raised levels have been detected hepatocellular carcinoma other cancers. An inherited or acquired imbalance, including inadequately low excessively high levels, as well inappropriate distribution body, a number diseases. In addition, recent groundbreaking study identified copper‐induced type programmed cell death named cuprotosis, mechanism which greatly deferred from that known modes. The first part provides overview regulation homeostasis discusses underlying mechanisms cuprotosis. second part, authors focus on functions liver diseases metabolic disorders, before discussing how this knowledge could contribute to development effective targets treat such

Language: Английский

Citations

9
Novel prognostic biomarker TBC1D1 is associated with immunotherapy resistance in gliomas DOI Creative Commons

Daqiang Song,

Qian Yang, Liuying Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 11, 2024

Glioma, an aggressive brain tumor, poses a challenge in understanding the mechanisms of treatment resistance, despite promising results from immunotherapy. We identified genes associated with immunotherapy resistance through analysis The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), and Gene Expression Omnibus (GEO) databases. Subsequently, qRT-PCR western blot analyses were conducted to measure mRNA protein levels TBC1 Domain Family Member 1 (TBC1D1), respectively. Additionally, Set Enrichment Analysis (GSEA) was employed reveal relevant signaling pathways, expression TBC1D1 immune cells analyzed using single-cell RNA sequencing (scRNA-seq) data GEO database. Tumor Immune Dysfunction Exclusion (TIDE) database utilized assess T-cell function, while Immunotherapy Resource (TIGER) evaluate relation TBC1D1. Furthermore, predictive performance molecules on prognosis assessed Kaplan-Meier plots, nomograms, ROC curves. significantly elevated tumor tissue glioma patients. high observed macrophages compared other cells, which negatively impacted T cell impaired response, promoted tolerance, led poor prognosis. Inhibition found potentially synergistically enhance efficacy prolong survival cancer patients gliomas. Heightened may facilitate immunosuppressive microenvironment predict Blocking could minimize

Language: Английский

Citations

3