Investigation of Nutritional Factors and Malnutrition Risk Prediction Model in Hospitalized Patients with Systemic Lupus Erythematosus in China

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8891 - 8904

Published: Nov. 1, 2024

Nutritional status is a critical indicator of overall health and immune function, significantly influencing treatment outcomes. Despite its importance, the nutritional patients with systemic lupus erythematosus (SLE) often receives insufficient attention. This study aims to evaluate SLE, identify factors associated malnutrition, develop risk prediction model for malnutrition in this population.

Language: Английский

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Prognostic and clinicopathological role of pretreatment systemic inflammation response index (SIRI) in gastric cancer: a systematic review and meta-analysis

World Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 20, 2024

The systemic inflammatory response index (SIRI) is calculated via the following formula: SIRI = monocyte count × neutrophil count/lymphocyte count. value of in predicting prognosis gastric cancer (GC) remains controversial. This study revealed precise effect GC through a meta-analysis. ability to predict was evaluated by calculating combined hazard ratios (HRs) and 95% confidence intervals (CIs). Furthermore, odds (ORs) CIs were determined analyze associations between clinicopathological characteristics patients with GC. Seven publications on total 1763 cases included this study. threshold 0.58 1.35, median 0.85. Our pooled findings that higher significantly linked poor overall survival (OS) (HR 1.87, CI 1.59–2.20, p < 0.001) disease-free (DFS; HR 1.88, 1.50–2.36, patients. However, did not exhibit significant association sex (OR 1.98, 0.82–4.75, 0.126), surgery type 0.96, 0.61–1.51, 0.847), tumor differentiation 0.75, 0.54–1.06, 0.099), or TNM stage 1.25, 0.34–4.62, 0.743) An elevated associated unfavorable OS DFS Thus, reliable biomarker for clinical practice.

Language: Английский

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Prognostic value of pretreatment peripheral blood hemoglobin×lymphocyte/monocyte ratio in patients with nasopharyngeal carcinoma.

PubMed, Journal Year: 2024, Volume and Issue: 49(12), P. 1909 - 1918

Published: Dec. 28, 2024

Peripheral whole blood cell counts have been used as prognostic indicators for various cancers, but their predictive value in nasopharyngeal carcinoma remain unclear. This study aims to evaluate the significance of pretreatment hemoglobin×lymphocyte/monocyte ratio (HLMR) non-recurrent, non-metastatic NPC patients undergoing definitive radiotherapy. Clinical and follow-up data from 805 who completed radiotherapy or chemoradiotherapy were retrospectively analyzed. Pretreatment hemoglobin, lymphocyte count, monocyte count collected calculate HLMR. Receiver operating characteristic (ROC) curves determine optimal cut-off Patients then classified into high low HLMR groups. The association between clinicopathological was assessed using chi-square tests. Independent factors overall survival (OS) progression-free (PFS) identified Cox proportional hazards models. A nomogram constructed based on independent predictors estimate patient rates, internal validation performed a cohort. ROC curve 605.5 predicting 5-year survival. Multivariate regression analysis revealed that T stage (HR=1.886, 95% CI 1.331 2.673, P<0.001), N (HR=2.021, 1.267 3.225, P=0.003), Eastern Cooperative Oncology Group (ECOG) score (HR=3.991, 1.257 12.677, P=0.019), concurrent regimen (HR=0.338, 0.156 0.731, P=0.006), (HR=0.648, 0.460 0.912, P=0.013) OS. including stage, training cohort predict 3-, 5-, 7-year OS, with C-index 0.713. area under OS 0.744, 0.665, 0.682, respectively. Calibration showed good agreement predicted observed rates. above results further confirmed may serve promising biomarker carcinoma.

Language: Английский

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Association of systemic immune-inflammatory index with cancer prevalence and mortality: Results from NHANES 1999-2010

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 8, 2023

Abstract Objective: To study the predictive effect of systemic immune-inflammatory index (SII) on cancer prevalence and mortality. Methods: Participants with SII status were screened from National Health Nutrition Examination Survey database 1999 to 2010, their baseline characteristics analyzed according tertile. Multivariable logistical or Cox proportional hazards models used analyze associations between The mortality was followed through December 31 2018. For further evaluation specified outcomes, restricted cubic spline two piecewise regression adopted. Results: This eventually included 26,049 individuals, whom 2,432 patients. According tertile group, increased significantly rise SII. In highest SII, related (OR=1.45, 95%CI= 1.31 - 1.61, p<0.05). Moreover, during a median follow-up 12.75 year, 329, 351, 1,202 cardiovascular, all-cause deaths occurred among patients, respectively. results indicated that level associated cardiovascular (HR=1.80, 1.28 2.52), (HR=1.64, 2.09) (HR=1.56, 1.31- 1.85). model adjusted for multiple covariates still showed same trend. U-shaped dose-response log-transformed (ln-SII) detected. threshold values ln-SII lowest risk prevalence, 5.44, 6.21, 6.27 Above thresholds, positively above outcomes. Conclusion: may be potential earlier warning marker total cancers.

Language: Английский

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