Medicine,
Journal Year:
2024,
Volume and Issue:
103(45), P. e40378 - e40378
Published: Nov. 8, 2024
Alcoholic
liver
disease
(ALD)
is
a
spectrum
of
damage
caused
by
chronic
alcohol
consumption.
The
progresses
in
stages,
starting
with
simple
fatty
liver,
progressing
to
alcoholic
hepatitis
and
potentially
leading
fibrosis
cirrhosis.
pathophysiology
ALD
complex
involves
several
cellular
molecular
mechanisms.
Recent
research
has
highlighted
the
role
long
non-coding
RNAs
(LncRNAs)
as
critical
regulators
development
progression
ALD.
This
article
reviews
current
understanding
LncRNAs
ALD,
focusing
on
their
functions
key
pathological
processes
potential
diagnostic
markers
therapeutic
targets.
Biocell,
Journal Year:
2024,
Volume and Issue:
48(3), P. 387 - 401
Published: Jan. 1, 2024
Glioblastoma
multiforme
(GBM),
the
most
common
and
aggressive
primary
brain
tumor
in
adults,
is
malignant
still
has
no
cure.However,
novel
role
of
long
non-coding
RNAs
(lncRNAs)
pathogenesis
glioblastoma
attracting
extensive
attention.LncRNAs
are
transcribed
RNA
molecules
over
200
nucleotides
that
do
not
encode
proteins.Unlike
small
RNAs,
such
as
microRNAs
(miRNAs),
lncRNAs
have
more
complex
secondary
tertiary
structures
enable
them
to
interact
with
DNA,
RNA,
proteins
perform
multiple
regulatory
functions.LncRNAs
act
molecular
sponges,
absorbing
sequestering
other
biomolecules,
particularly
miRNAs,
thereby
preventing
these
from
performing
their
normal
influence
through
gene
expression
regulation,
sponge
capacity,
epigenetic
modulation,
signaling
pathway
interactions.In
glioblastoma,
a
large
number
been
found
be
abnormally
expressed,
affecting
growth,
invasion
resistance
treatment.Due
its
disease-specific
patterns,
lncRNA
become
potential
biomarker
for
promising
new
therapeutic
target.This
paper
discusses
spongy
applications,
which
will
lay
foundation
our
understanding
biology
development
diagnostic
strategies
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10079 - 10079
Published: Sept. 19, 2024
RNAs,
especially
non-coding
RNAs
(ncRNAs),
are
crucial
players
in
regulating
cellular
mechanisms
due
to
their
ability
interact
with
and
regulate
other
molecules.
Altered
expression
patterns
of
ncRNAs
have
been
observed
prostate
cancer
(PCa),
contributing
the
disease’s
initiation,
progression,
treatment
response.
This
study
aimed
evaluate
a
specific
set
including
long
(lncRNAs),
microRNAs
(miRNAs),
mRNAs,
discriminate
between
PCa
non-neoplastic
condition
benign
prostatic
hyperplasia
(BPH).
After
selecting
by
literature
mining
most
relevant
differentially
expressed
biofluids
from
patients,
we
evaluated
discriminatory
power
samples
unfiltered
urine
50
BPH
patients
using
both
real-time
PCR
droplet
digital
(ddPCR).
Additionally,
also
optimized
protocol
for
sample
manipulation
RNA
extraction.
two-way
validation
allowed
us
establish
that
miRNAs
(i.e.,
miR-27b-3p,
miR-574-3p,
miR-30a-5p,
miR-125b-5p)
more
efficient
biomarkers
compared
(mRNAs
lncRNAs)
(e.g.,
PCA3,
PCAT18,
KLK3),
as
dysregulation
was
consistently
reported
whole
those
statistically
significant
manner
regardless
quantification
methodology
performed.
Moreover,
increase
diagnostic
performance
when
molecular
signatures
composed
different
were
considered.
Hence,
abovementioned
circulating
represent
excellent
potential
non-invasive
capable
effectively
distinguishing
individuals
BPH,
potentially
reducing
overdiagnosis.
Cancer and Metastasis Reviews,
Journal Year:
2024,
Volume and Issue:
43(4), P. 1611 - 1627
Published: Sept. 24, 2024
Prostate
cancer
(PCa)
is
one
of
the
most
commonly
diagnosed
malignancies
and
main
causes
cancer-related
deaths
worldwide.
It
characterized
by
high
heterogeneity,
ranging
from
slow-growing
tumor
to
metastatic
disease.
Since
both
therapy
selection
outcome
strongly
rely
on
appropriate
patient
stratification,
it
crucial
differentiate
benign
more
aggressive
conditions
using
new
improved
diagnostic
prognostic
biomarkers.
Extracellular
vesicles
(EVs)
are
membrane-coated
particles
carrying
a
specific
biological
cargo
composed
nucleic
acids,
proteins,
metabolites.
Here,
we
provide
an
overview
role
EVs
in
PCa,
focusing
their
function
clinical
value.
Specifically,
summarize
oncogenic
mediating
interactions
with
PCa
microenvironment
as
well
horizontal
transfer
traits
drug
resistance
between
cells.
Furthermore,
discuss
potential
usage
innovative
tools
for
diagnosis
prognosis.
