The future of whole genome sequencing in pediatrics

Liječnički vjesnik, Journal Year: 2023, Volume and Issue: 145(Supp 5)

Published: Oct. 10, 2023

Language: Английский

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A STEP ahead for CAR-T cell therapy of large B cell lymphoma: understanding the molecular determinants of resistance

Translational Cancer Research, Journal Year: 2023, Volume and Issue: 12(11), P. 2970 - 2975

Published: Nov. 1, 2023

Language: Английский

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Editorial: Liquid biopsies in hematological malignancies

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 12, 2024

Keywords: liquid biopsies, hematological malignancies, minimal residual disease (MRD), immunotherapy, next-generation sequence (NGS)

Language: Английский

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Novel Immunological Markers of Intestinal Impairment Indicative of HIV-1 Status and/or Subclinical Atherosclerosis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

ABSTRACT Antiretroviral therapy (ART) controls HIV-1 replication in people with (PWH), but immunological restauration at mucosal barrier surfaces is not achieved. This fuels microbial translocation, chronic immune activation, and increased comorbidities, including cardiovascular disease (CVD). Here, we sought to identify novel markers of impairment the blood predict HIV and/or CVD status. Flow cytometry was used characterize CD326/EpCAM + intestinal epithelial cells (IEC); CD4 T-cells; CD8 intraepithelial lymphocytes (IELs); subsets T-cells expressing Th17 (CCR6) gut-homing (Itgβ7) markers. To this aim, collected peripheral mononuclear (PBMCs) from 42 ART-treated PWH (HIV ) 40 uninfected participants - Canadian Aging Cohort Study (CHACS). Both groups were categorized based on presence coronary atherosclerotic plaques measured by CT scan angiography as total plaque volume (TPV, mm 3 ). Our findings associate status frequencies circulating CD326 IEC; activated (CD69 HLA-DR (ItgαE CCR6 CCR9 phenotypes, Itgβ7 decreased IELs. Logistic regression analyses confirmed predictive capacity above cellular regarding Spearman correlation revealed a positive between TPV T-cell frequencies.Together, these results highlighted significant dysregulation persistent alterations despite effective viral suppression ART linked abundance burden. Thus, strategies targeting gut-immune axis restoration may reduce onset improve long-term health outcomes PWH.

Language: Английский

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Mutational heterogeneity in large B-cell lymphoma: insights from paired biopsies

Annals of Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

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