Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis DOI Creative Commons
C. Llaó-Cid,

Blanca Peguera,

Piotr Kobialka

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 29, 2024

Abstract Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover role angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) development mouse. Early postnatal FLRT2 deletion reveals specific defects retinal veins, impacting proliferation, sprouting polarity that result reduced tip cells at front. interacts with VE-cadherin together endocytic adaptor Numb contribute modulation adherens junction morphology both retina cerebral cortex vivo. Utilizing expansion microscopy, visualize altered dynamic distribution tissue mutants. Additionally, cortical vessels regulates crosstalk between tight junctions, influencing blood-brain barrier development. Our findings position a vein-specific regulator CNS

Language: Английский

Identification of an autophagy- and macropinocytosis-related prognostic signature for the prediction of prognosis and therapeutic response in gastric cancer DOI
Yuhua Shi,

Aifeng Qiu,

Hengfeng Cui

et al.

Genes & Genomics, Journal Year: 2024, Volume and Issue: 46(10), P. 1149 - 1164

Published: Aug. 16, 2024

Language: Английский

Citations

0
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis DOI Open Access
C. Llaó-Cid,

Blanca Peguera,

Piotr Kobialka

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover significant role angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) development mouse. Early postnatal FLRT2 deletion reveals specific defects retinal veins, impacting proliferation, sprouting polarity that result reduced tip cells at front. interacts with VE-cadherin together endocytic adaptor Numb contribute modulation adherens junction morphology both retina cerebral cortex vivo . Utilizing expansion microscopy, visualize altered dynamic distribution tissue mutants. Additionally, cortical vessels regulates crosstalk between tight junctions, influencing blood-brain barrier development. Our findings position a vein-specific crucial regulator CNS

Language: Английский

Citations

0
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis DOI Creative Commons
C. Llaó-Cid,

Blanca Peguera,

Piotr Kobialka

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 29, 2024

Abstract Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover role angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) development mouse. Early postnatal FLRT2 deletion reveals specific defects retinal veins, impacting proliferation, sprouting polarity that result reduced tip cells at front. interacts with VE-cadherin together endocytic adaptor Numb contribute modulation adherens junction morphology both retina cerebral cortex vivo. Utilizing expansion microscopy, visualize altered dynamic distribution tissue mutants. Additionally, cortical vessels regulates crosstalk between tight junctions, influencing blood-brain barrier development. Our findings position a vein-specific regulator CNS

Language: Английский

Citations

0