Difficulties in differential diagnosis of glial tumors and limbic encephalitis: literature data, clinical observations DOI Creative Commons
Anna A. Belkina, Е. О. Чеканова, Inessa Zakroyshchikova

et al.

Neurology neuropsychiatry Psychosomatics, Journal Year: 2024, Volume and Issue: 16(4), P. 54 - 60

Published: Aug. 21, 2024

Temporal and parahippocampal glial tumors at early morphological stages of their development may mimic the clinical neuroimaging picture limbic encephalitis. Delayed diagnosis glioblastoma can have a negative impact on prognosis disease, which is why there need to find approaches for its earlier detection. The aim this paper analyze possible difficulties errors in differential autoimmune encephalitis (AE) based literature data our own observations. Features such as onset disease young age, subacute symptoms, response immunosuppressive therapy MRI imaging bilateral T2 hyperintense changes areas are typical AE, but do not exclude primary tumor central nervous system. Therefore, caution should be exercised regarding likelihood brain when patients any age group present with symptoms characteristic especially if no specific AE antibodies detected. To shorten time diagnosis, multidisciplinary approach, critical analysis data, shortening examination interval an increase frequency follow-up examinations required.

Language: Английский

Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: A report of the PET/RANO group DOI
Norbert Galldiks, Timothy J. Kaufmann, Philipp Kickingereder

et al.

Neuro-Oncology, Journal Year: 2024, Volume and Issue: 26(7), P. 1181 - 1194

Published: March 11, 2024

Abstract Brain tumor diagnostics have significantly evolved with the use of positron emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation extent, prognostication, differentiation between relapse treatment-related changes, evaluation response anticancer therapy. particular, joint recommendations Response Assessment in Neuro-Oncology (RANO) Group, European Association Neuro-oncology, major American Nuclear Medicine societies highlighted that additional value radiolabeled amino acids compared MRI alone is outstanding its widespread should be supported. For steadily increasing practice, Standardization Subcommittee Jumpstarting Tumor Drug Development Coalition provided more recently an updated acquisition protocol widely used dynamic susceptibility contrast perfusion MRI. Besides acid PET other tracers techniques (e.g. MR spectroscopy) are considerable interest increasingly integrated into everyday practice. Nevertheless, shortcomings which considered routine. This comprehensive review provides overview potential challenges, limitations, pitfalls associated patients gliomas or brain metastases. Despite issues, continue play indispensable role management. Acknowledging mitigating challenges through interdisciplinary collaboration, standardized protocols, continuous innovation will further enhance utility guiding optimal patient care.

Language: Английский

Citations

16
Artificial intelligence-based radiogenomics reveals the potential immunoregulatory role of COL22A1 in glioma and its induced autoimmune encephalitis DOI Creative Commons

Bingchao Yan,

Qian Chen, Da‐Cheng Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Background The tumor microenvironment plays a crucial role in the progression of both glioma and glioma-induced autoimmune encephalitis. However, there remains significant lack effective therapeutic targets for these diseases. Method We collected 54 CT images patients encephalitis patients, respectively. Radiomics features were extracted from tumors regions using Python, followed by dimensionality reduction via random forest lasso regression, construction radiomics-based risk scores. Genomic data matched with clinical information analyzed to identify key prognostic genes significantly associated Gene expression was validated immunohistochemistry our samples. Immune infiltration evaluated five algorithms (MCP-counter, EPIC, TIMER, QUANT IPS). association between hub immune checkpoint markers as well immunoregulation-related also Spearman correlation. Results identified 980 radiomics patient selected four through regression build score. COL22A1 strongly correlated score gene. higher glioblastoma tissues cell lines, factors such age, WHO grade, IDH mutation status. analysis indicated associations diverse stromal populations, including CD8 + T cells, macrophages, CAFs. positively checkpoints immune-regulated genes. Conclusion Our study highlights critical gliomas glioma-Induced Autoimmune Encephalitis, demonstrating its strong poor prognosis involvement regulation.

Language: Английский

Citations

0
High-grade gliomas with autoimmune encephalitis-like presentation: case report and systematic review of the literature DOI
Giulia Sofia Cereda, Fabio Martino Doniselli, Francesco Deleo

et al.

Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Mimickers of autoimmune encephalitis: a literature review DOI Creative Commons
Mohamad Sami Alshutaihi, Muhammad Mazketly,

Mohannad Tabbakh

et al.

Journal of International Medical Research, Journal Year: 2024, Volume and Issue: 52(5)

Published: May 1, 2024

Autoimmune encephalitis (AIE) is a rapid, progressive neurological disorder characterized by nervous system inflammation. While the Graus criteria are best known for AIE diagnosis, other differential diagnoses meeting must be considered before management. This narrative review discusses most common etiologies that resemble AIE. We suggest routine exclusion of mimickers confirming an diagnosis. reviewed 28 studies including 356 patients. The main initial diagnosis was AIE, then paraneoplastic limbic and anti-N-methyl-D-aspartate receptor encephalitis. Only 194 patients met possible criteria. frequent conditions among total population were dementia, neurodegenerative diseases, psychiatric functional disorders. often misdiagnosed, leading to unnecessary treatment. Despite publication criteria, medical cases mimicking this condition being published. Many diseases entering could excluded through detailed history, examination, laboratory analysis, investigations, cerebrospinal fluid brain magnetic resonance imaging. However, some complied with having concurrent antineuronal antibodies, which true mimickers. suspicion primarily clinical, but definitive requires various diagnostic tools.

Language: Английский

Citations

1
Difficulties in differential diagnosis of glial tumors and limbic encephalitis: literature data, clinical observations DOI Creative Commons
Anna A. Belkina, Е. О. Чеканова, Inessa Zakroyshchikova

et al.

Neurology neuropsychiatry Psychosomatics, Journal Year: 2024, Volume and Issue: 16(4), P. 54 - 60

Published: Aug. 21, 2024

Temporal and parahippocampal glial tumors at early morphological stages of their development may mimic the clinical neuroimaging picture limbic encephalitis. Delayed diagnosis glioblastoma can have a negative impact on prognosis disease, which is why there need to find approaches for its earlier detection. The aim this paper analyze possible difficulties errors in differential autoimmune encephalitis (AE) based literature data our own observations. Features such as onset disease young age, subacute symptoms, response immunosuppressive therapy MRI imaging bilateral T2 hyperintense changes areas are typical AE, but do not exclude primary tumor central nervous system. Therefore, caution should be exercised regarding likelihood brain when patients any age group present with symptoms characteristic especially if no specific AE antibodies detected. To shorten time diagnosis, multidisciplinary approach, critical analysis data, shortening examination interval an increase frequency follow-up examinations required.

Language: Английский

Citations

0