Revisiting the CXCL13/CXCR5 Axis in the Tumor Microenvironment in the Era of Single-cell Omics: Implications for Immunotherapy DOI Creative Commons

Xuanyu Gu,

Dongyu Li, Peng Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217278 - 217278

Published: Sept. 1, 2024

Language: Английский

Single-cell transcriptomic analysis reveals efferocytosis signature predicting immunotherapy response in hepatocellular carcinoma DOI

Longhu Li,

Guangyao Li,

Wangfeng Zhai

et al.

Digestive and Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
A Novel Gene Signature for Predicting Outcome in Colorectal Cancer Patients Based on Tumor Cell-Endothelial Cell Interaction via Single-Cell Sequencing and Machine Learning DOI Creative Commons

Lina Pang,

Qi Sun, Wenyue Wang

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42237 - e42237

Published: Jan. 1, 2025

Language: Английский

Citations

0
Crosstalk of SPINK4 Expression With Patient Mortality, Immunotherapy and Metastasis in Pan-Cancer Based on Integrated Multi-Omics Analyses DOI Open Access

Xiuhua Cao,

Na Luo, Xiaoyan Liu

et al.

OncoTargets and Therapy, Journal Year: 2025, Volume and Issue: Volume 18, P. 161 - 177

Published: Feb. 1, 2025

Background: Cancer remains a major global health challenge, with early detection and prompt treatment being crucial for reducing mortality rates. The SPINK4 has been linked to the development of several tumors, there is growing evidence its involvement. However, specific functions effects in different cancer types remain unclear. Methods: association between expression levels tumor progression was investigated confirmed using TCGA dataset. Kaplan-Meier curves were utilized examine correlation survival outcomes pan-cancer patients. Pearson method employed investigate microenvironment, stemness score, immunoinfiltrating subtype, chemotherapy sensitivity human types. Wound healing Transwell assays performed confirm roles model gene colon adenocarcinoma cells. Results: shows heterogeneity across tissues, closely associated poor prognosis, immune cell invasion, resistance, metastasis various cancer. Mutation hold significant predictive value prognosis In addition, significantly correlated microenvironment (stromal cells cells) score (DNAss RNAss) particularly BLCA COAD. Single-cell sequencing analysis showed that mainly expressed endothelial malignant Drug resistance drugs. Importantly, overexpression promoted lines (HCT116 RKO), whereas knockout markedly inhibited their metastasis. Conclusion: These findings reveal role process may have implications diagnosis future. Keywords: analysis, infiltration, genetic alteration, single-cell sequencing, drug

Language: Английский

Citations

0
Genetic Signatures Upon Transition from Colorectal Polyps to colon Cancer DOI
Mehran Radak,

Farahnoosh Khodabakhsh Ravand,

Nakisa Ghamari

et al.

Current Tissue Microenvironment Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
TNFRSF12A expression in stomach adenocarcinoma and its preliminary role in predicting immunotherapy response DOI Creative Commons

Linde Sun,

Linlin Zhang, Zheng Wan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 5, 2025

TNFRSF12A is abnormally expressed in various malignancies, especially stomach adenocarcinoma (STAD), which related to tumor invasiveness and prognosis of patients. This study examined the expression pattern STAD predicted immunotherapy response. Data were derived from The Cancer Gene Atlas (TCGA), Expression Omnibus (GEO), Profiling Interactive Analysis (GEPIA) analyze pan-cancer STAD, as well its correlation with clinical features. Biological pathways involved analyzed by "clusterProfiler" package. Immune cell infiltration was evaluated "GSVA" "CIBERSORT" packages. Immunotherapy response assessed TIDE score mutation burden (TMB) level. level single scRNA-seq. Finally, vitro test detected mRNA cells, Wound healing Transwell assays performed measure capabilities migrate invade. highly STAD. However, did not shown significant difference relation exhibited notably positive many carcinogenic signaling immune cells such T macrophages. High group showed a higher score, Exclusion TMB than low group, indicated that patients high responded more poorly immunotherapy. most checkpoint genes. By scRNA-seq analysis, chiefly Fibroblasts Mast Further, verified migration invasion suppressed silencing (p<0.05). present only reveals potential therapeutic target for but also explores great finding opens up new way thinking personalized treatment

Language: Английский

Citations

0
Revisiting the CXCL13/CXCR5 Axis in the Tumor Microenvironment in the Era of Single-cell Omics: Implications for Immunotherapy DOI Creative Commons

Xuanyu Gu,

Dongyu Li, Peng Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217278 - 217278

Published: Sept. 1, 2024

Language: Английский

Citations

2