Best Practice & Research Clinical Gastroenterology, Journal Year: 2024, Volume and Issue: 72, P. 101953 - 101953
Published: Sept. 1, 2024
Language: Английский
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: June 6, 2024
Microplastics (MPs) are particles with a diameter of <5 mm. The disposal plastic waste into the environment poses significant and pressing issue concern globally. Growing worry has been expressed in recent years over impact MPs on both human health entire natural ecosystem. feeding digestive capabilities marine organisms, as well hinder development plant roots leaves. Numerous studies have shown that majority individuals consume substantial quantities either through their dietary intake or by inhaling them. identified various biological samples, such lungs, stool, placenta, sputum, breast milk, liver, blood. can cause illnesses humans, depending how they enter body. Healthy sustainable ecosystems depend proper functioning microbiota, however, disrupt balance microbiota. Also, due to high surface area compared volume chemical characteristics, act pollutant absorbers different environments. Multiple policies initiatives exist at domestic global levels mitigate pollution caused MPs. Various techniques currently employed remove MPs, biodegradation, filtration systems, incineration, landfill disposal, recycling, among others. In this review, we will discuss sources types presence environments food, mechanisms adsorption methods removing algae microbes.
Language: Английский
Citations
6
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Sept. 17, 2024
Background The relationship between dysbiosis of the gastrointestinal microbiota and gastric cancer (GC) has been extensively studied. However, alterations in GC patients vary widely across studies, reproducible diagnostic biomarkers for early are still lacking multiple populations. Thus, this study aimed to characterize microbial communities involved carcinogenesis through a meta-analysis published open datasets. Methods We analyzed 16S rRNA sequencing data from 1,642 biopsy samples 394 stool 11 independent studies. VSEARCH, QIIME R packages such as vegan, phyloseq, cooccur, random forest were used processing analysis. PICRUSt software was employed predict functions. Results α-diversity results indicated significant differences intratumoral compared non-cancer patients, while no observed fecal microbiota. Network analysis showed that positive correlation with GC-enriched bacteria increased, GC-depleted decreased healthy individuals. Functional analyses pathways related carbohydrate metabolism significantly enriched GC, biosynthesis unsaturated fatty acids diminished. Additionally, we investigated non- Helicobacter pylori (HP) commensals, which crucial both HP -negative -positive GC. Random models, constructed using specific taxa associated identified LEfSe analysis, revealed combination Lactobacillus Streptococcus included alone could effectively discriminate individuals (area under curve (AUC) = 0.7949). This finding also validated an cohort (AUC 0.7712). Conclusions examined dual microecological perspective Lactobacillus, Streptococcus, Roseburia, Faecalibacterium Phascolarctobacterium intestinal-specific co-differential bacteria. Furthermore, it confirmed validity GC-specific markers populations, may aid non-invasive diagnosis
Language: Английский
Citations
5
Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)
Published: Dec. 23, 2024
Obesity is a multifactorial condition influenced by genetic, environmental, and microbiome-related factors. The gut microbiome plays vital role in maintaining intestinal health, increasing mucus creation, helping the epithelium mend, regulating short-chain fatty acid (SCFA) production. These tasks are for managing metabolism energy balance. Dysbiosis—an imbalance microbiome—leads to increased appetite rise of metabolic disorders, both fuel obesity its issues. Furthermore, childhood connects with unique shifts microbiota makeup. For instance, there surge pro-inflammatory bacteria compared children who not obese. Considering intricate nature variety microbiota, additional investigations necessary clarify exact involvement beginnings advancement related dilemmas. Currently, therapeutic methods like probiotics, prebiotics, synbiotics, fecal transplantation (FMT), dietary interventions Mediterranean ketogenic diets, physical activity show potential adjusting fight aid weight loss. review underscores integration microbial metabolites pharmacological agents such as orlistat semaglutide restoring homeostasis. However, more clinical tests essential refine doses, frequency, lasting effectiveness these treatments. This narrative overview compiles existing knowledge on multifaceted much more, showcasing possible treatment strategies addressing health challenges.
Language: Английский
Citations
5
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 21, 2024
Globally, people widely recognize cancer as one of the most lethal diseases due to its high mortality rates and lack effective treatment options. Ongoing research into therapies remains a critical area inquiry, holding significant social relevance. Currently used treatment, such chemotherapy, radiation, or surgery, often suffers from other problems like damaging side effects, inaccuracy, ability clear tumors. Conventional are usually imprecise ineffective develop resistance treatments recurs. Cancer patients need fresh innovative that can reduce effects while maximizing effectiveness. In recent decades several breakthroughs in these, areas medical research, have paved way for new avenues fighting including more focused alternatives. This study reviews exciting possibilities mesenchymal stem cells (MSCs), nanomaterials, microbial agents modern realm treatment. Nanoparticles (NPs) demonstrated surprisingly potential. They improve drug delivery systems (DDS) significantly, enhance imaging techniques remarkably, target selectively protecting healthy tissues. MSCs play double role tissue repair vehicle novel gene NPs loaded with therapeutic agents. Additionally, utilizing agents, particularly those involving bacteria, offer an inventive approach review investigates potential MSCs, addressing shortcomings conventional therapies. We will also discuss challenges limitations using these approaches.
Language: Английский
Citations
4
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 24, 2025
Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron an essential micronutrient plays vital role in various biological processes, but also has pro-oxidant pro-inflammatory effects may contribute to carcinogenesis. The relationship between iron CRC complex influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, excretion iron, well genetic environmental factors modulate homeostasis. This review article aims provide overview the current evidences on CRC, discussing potential mechanisms which affect development progression, implications for prevention treatment. tries focus following aspects: introduction its heme non-heme patterns, nutrition, overload deficiency especially surgery outcome therapy blood transfusion CRC.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 18, 2025
Antibiotics represent one of the most significant medical breakthroughs twentieth century, playing a critical role in combating bacterial infections. However, rapid emergence antibiotic resistance has become major global health crisis, significantly complicating treatment protocols. This paper provides narrative review current state resistance, synthesizing findings from primary research and comprehensive articles to examine various mechanisms bacteria employ counteract antibiotics. One sources is improper use antibiotics livestock industry. The drug-resistant microorganisms human activities industrial production presented environmental public concerns. Today, resistant nosocomial infections occur following long-term hospitalization patients, causing death many people, so there an urgent need for alternative treatments. In response this non-antibiotic therapeutic strategies have been proposed, including bacteriophages, probiotics, postbiotics, synbiotics, fecal microbiota transplantation (FMT), nanoparticles (NPs), antimicrobial peptides (AMPs), antibodies, traditional medicines, toxin-antitoxin (TA) system. While these approaches offer innovative solutions addressing preserving efficacy therapies, challenges such as safety, cost-effectiveness, regulatory hurdles, large-scale implementation remain. examines potential limitations strategies, offering balanced perspective on their managing mitigating broader impact resistance.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 1, 2025
There is a widespread distribution of gram-negative bacteria worldwide, which are responsible for the deaths numerous patients each year. The illnesses they cause can be localized and systemic, these possess several key virulence factors that contribute to their pathogenicity. In recent years, distinct mechanisms pathogenesis have evolved remain largely unknown scientists medical experts. Among these, outer membrane vesicles (OMVs) undoubtedly one most significant influencing virulence. OMVs contain various bacterial compounds diverse effects on host organisms immune system, potentially exacerbating disease inflammation while evading responses. This review comprehensively examines role in pathogenesis, interaction with cells, potential biomedical applications. Understanding molecular governing OMV biogenesis function could pave way novel antimicrobial strategies therapeutic interventions.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1252 - 1252
Published: April 7, 2025
The gut microbiome plays a pivotal role in modulating cancer therapies, including immunotherapy and chemotherapy. Emerging evidence demonstrates its influence on treatment efficacy, immune response, resistance mechanisms. Specific microbial taxa enhance checkpoint inhibitor while dysbiosis can contribute to adverse outcomes. Chemotherapy effectiveness is also influenced by composition, with engineered probiotics prebiotics offering promising strategies drug delivery reduce toxicity. Moreover, metabolites, such as short-chain fatty acids, systems have shown potential improve therapeutic responses. These findings underscore the importance of personalized microbiome-based approaches optimizing treatments.
Language: Английский
Citations
0
Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107572 - 107572
Published: April 1, 2025
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 30, 2025
The human microbiota comprises a diverse microbial ecosystem that significantly impacts health and disease. Among its components, the gut plays crucial role in regulating metabolic, immunologic, inflammatory responses. Dysbiosis, an imbalance composition, has been linked to carcinogenesis through mechanisms such as chronic inflammation, metabolic disturbances, epigenetic modifications, immune system dysregulation. Additionally, dysbiosis influences efficacy toxicity of cancer therapies. Given these associations, there is growing interest leveraging biomarker for detection outcome prediction. Notably, distinct signatures have identified across various types, suggesting their potential diagnostic markers. Furthermore, modulation presents promising avenue improving treatment outcomes strategies antibiotics, prebiotics, probiotics, fecal transplantation, dietary interventions, small-molecule inhibitors, phage therapy. To explore relationships, we conducted comprehensive literature review using Web Science, Scopus, PubMed, MEDLINE, Embase, Google Scholar our primary online databases, focusing on indexed peer-reviewed articles up present year. This aims elucidate development, examine molecular involved, assess impact highlight microbiota-based therapeutic discuss applications management. A deeper understanding intricate interplay between may pave way novel approaches prevention, early detection, optimization.
Language: Английский
Citations
0