Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity DOI Creative Commons

Yajie LIU Master,

Ruilin Wang

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Background Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Index (ALI) effectively reflects the systemic inflammation level nutritional metabolic status of patients. However, its relationship with hepatic steatosis fibrosis remains unclear. study aimed to provide novel insights into prevention by examining between ALI Controlled Attenuation Parameter (CAP) Liver Stiffness Measurement (LSM). Methods To identify connection fibrosis, this utilized descriptive analysis, multivariate linear regression, smooth curve fitting, threshold effect analysis investigate data from National Health Nutrition Examination Survey conducted 2017–2020. Results levels NAFLD (AHF) groups were considerably elevated than control group, statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 63.360, 0.001). Multiple regression analyses indicated significant positive associations quartiles both CAP LSM levels. There was a fitting LSM, inflection points at 88.287 98.420, respectively. Conclusion findings suggest correlation LSM. Maintaining within an appropriate range may help mitigate prevalence fibrosis.

Language: Английский

Predictive Efficacy of the Advanced Lung Cancer Inflammation Index in Hepatocellular Carcinoma After Hepatectomy DOI Creative Commons

Xin Qiu,

Shuang Shen,

Donghong Lu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5197 - 5210

Published: Aug. 1, 2024

Hepatocellular carcinoma (HCC) presents a significant global health challenge due to its poor prognosis and high recurrence rates post-surgery. This study examines the predictive efficacy of Advanced Lung Cancer Inflammation Index (ALI) in assessing post-hepatectomy patients with HCC.

Language: Английский

Citations

4
Advanced lung cancer inflammation index: a key predictor of hepatic steatosis and fibrosis severity DOI Creative Commons
Yajie Liu, Ruilin Wang

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The Advanced Lung Cancer Inflammation Index (ALI) reflects levels of systemic inflammation and nutrient metabolism in patients. However, connection between ALI hepatic steatosis fibrosis remains unclear. This study aims to explore the potential association ALI, Controlled Attenuation Parameter (CAP), Liver Stiffness Measurement (LSM), offering new perspectives for prevention fibrosis. Using data from National Health Nutrition Examination Survey database spanning 2017 2020, a cross-sectional 6591 participants aged 20 years older was performed assess relationship Smooth curve fitting generalized additive models were used further evaluate whether there nonlinear CAP, LSM, threshold effect analysis find inflection point. A two-part linear regression model applied estimate effects. Subgroup interaction LSM. Furthermore, verify efficacy we ROC curves compare with nutritional markers (FIB-4 index, GNRI) that have been reported be associated liver disease. MASLD 4 groups considerably elevated than control group, statistical significance (PMASLD<0.001, PAHF =0.013). Multiple analyses indicated significant positive associations its quartiles both CAP[b(95%CI) ALI=0.510(0.465,0.555), P<0.001] LSM [b(95%CI) ALI=0.011(0.009,0.013), P<0.001). There smooth CAP points at 88.287 98.420 (PLog likelihood ratio<0.001), respectively. interacts relation gender [OR(95%CI)female=0.095(0.039-0.150), OR(95%CI)male=0.174(0.118-0.230), Pfor interaction=0.044] smoking [OR(95% CI)<100cigarettes life=0.086(0.035-0.137), OR(95% CI)>100cigarettes life=0.177(0.115-0.240), interaction=0.023], patients HL CI)HL=0.014(0.008-0.019), interaction<0.001]. findings suggest correlation Maintaining within an appropriate range may help mitigate prevalence

Language: Английский

Citations

0
Prognostic value of advanced lung cancer inflammation index for upper tract urothelial carcinoma DOI Creative Commons
Qihan Fu, Peng Dou, Peng Zhang

et al.

Asian Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A novel nutritional inflammation index for predicting mortality in acute ischemic stroke patients: insights into advanced lung cancer inflammation index from the Medical Information Mart for Intensive Care-IV database DOI Creative Commons
Yongwei Huang,

Xiaoyi Wang,

Zongping Li

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 5, 2024

This investigation aimed to delineate the association between advanced lung cancer inflammation index (ALI) and all-cause mortality (ACM) in individuals experiencing acute ischemic stroke (AIS).

Language: Английский

Citations

2
Independent and joint influence of depression and advanced lung cancer inflammation index on mortality among individuals with chronic kidney disease DOI Creative Commons
Jianping Zhou, Wenjun Liu, Xiaoxin Liu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

Background The combined effect of depression and nutritional-inflammatory status on mortality in the chronic kidney disease (CKD) population is unclear. Methods We prospectively analyzed 3,934 (weighted population: 22,611,423) CKD participants from National Health Nutrition Examination Survey (2007–2018). Depression were assessed with Patient Questionnaire 9 (PHQ-9) Advanced Lung Cancer Inflammation Index (ALI), respectively. Weighted multivariate COX regression models, restricted cubic splines (RCS) stratified analyses used to investigate association PHQ-9 scores ALI all-cause mortality. Results During a median follow-up 5.8 years (interquartile range 3.4–8.6 years), total 985 patients died (25.0%). Each point increase patient’s score increased risk by 4% (HR, 1.04; 95% CI, 1.02–1.06; p &lt; 0.001), full adjusted model. However, an levels was associated decreased risk. HRs (95% CI) 0.76 (0.65–0.90), 0.70 (0.57–0.86), 0.51 (0.41–0.64) Q2, Q3, Q4 compared Q1 ALI, In addition, joint analysis showed that without higher reduced Namely, highest group (Q4) had lowest 0.32; 0.21–0.48). Furthermore, this consistent across all subgroups, no significant interaction found ( &gt; 0.05 for interaction). Conclusion nationally representative sample US CKD, coexisting poorer nutrition-inflammation significantly

Language: Английский

Citations

1
Predictive Value of the Advanced Lung Cancer Inflammation Index for the Postoperative Complications of Lung Resections in Patients with Bronchiectasis: A Retrospective Study Short Title : Study on the Correlation between the Advanced Lung Cancer Inflammation Index and Patients with Bronchiectasis DOI Creative Commons
Yang Gu, Jinbai Miao,

Hang Zheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Abstract Background: Bronchiectasis patients often suffer from systemic inflammation and malnutrition, which negatively affect their prognosis. The advanced lung cancer index (ALI) has emerged as a novel biomarker that reflects malnutrition. However, its utility in predicting postoperative complications bronchiectasis undergoing localized surgical resection remains to be clarified. Method: This retrospective study included 160 with who underwent single lobectomy at our center April 2012 December 2022. optimal ALI cutoff point was established using the receiver operating characteristic (ROC) curve. Univariate multivariate logistic regression analyses were employed identify independent risk factors for complications. Results: value determined 38.37. Compared high group, low group exhibited significantly greater incidence of open chest surgeries (P=0.001), increased duration (P=0.024), intraoperative blood loss (P=0.016), prolonged tube drainage extended hospital stays after operation rate (P=0.006). Multivariate analysis revealed duration, body mass (BMI), preoperative To predict likelihood these complications, we developed nomogram incorporating factors, demonstrated predictive accuracy an area under curve (AUC) 0.792. Conclusion: The serves predictor lobectomy.

Language: Английский

Citations

0
Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity DOI Creative Commons

Yajie LIU Master,

Ruilin Wang

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Background Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Index (ALI) effectively reflects the systemic inflammation level nutritional metabolic status of patients. However, its relationship with hepatic steatosis fibrosis remains unclear. study aimed to provide novel insights into prevention by examining between ALI Controlled Attenuation Parameter (CAP) Liver Stiffness Measurement (LSM). Methods To identify connection fibrosis, this utilized descriptive analysis, multivariate linear regression, smooth curve fitting, threshold effect analysis investigate data from National Health Nutrition Examination Survey conducted 2017–2020. Results levels NAFLD (AHF) groups were considerably elevated than control group, statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 63.360, 0.001). Multiple regression analyses indicated significant positive associations quartiles both CAP LSM levels. There was a fitting LSM, inflection points at 88.287 98.420, respectively. Conclusion findings suggest correlation LSM. Maintaining within an appropriate range may help mitigate prevalence fibrosis.

Language: Английский

Citations

0