Revolutionizing Nanovaccines: A New Era of Immunization

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 27, 2025

Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.

Language: Английский

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Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110921 - 110921

Published: Feb. 1, 2025

Language: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

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Cancer‐Targeting Peptides Functionalized With Polyarginine Enables GRP78‐Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells

Journal of Peptide Science, Journal Year: 2025, Volume and Issue: 31(3)

Published: Feb. 18, 2025

ABSTRACT This study investigated a peptide‐based GRP78‐targeting strategy for short‐interfering (si) RNA delivery in cancer cells. Synthetic fluorescein‐labeled amphiphilic peptides composed of the hydrophobic cell surface (cs) and hydrophilic, polycationic arginine‐rich penetrating demonstrated GRP78‐dependent uptake DU145 prostate cells, to lesser extent non‐cancerous human lung fibroblast WI‐38 line. Mechanistic studies revealed energy‐dependent GRP78 receptor‐mediated endocytosis peptide with polyarginine (W1‐R9). The cytosolic accumulation this underscored its potential utility siRNA delivery. Peptide:siRNA complexes formed stably condensed nanoparticles, calcium functioning as an ionic stabilizer additive promoting endosomal escape interference (RNAi) activity. Preliminary transfections cells that knockdown led interplay between pro‐survival death outcomes under ER stress induction. Thus, enables efficient specific class bio‐active synthetic is important investigation biology, leading innovation cancer‐targeted gene therapy approaches.

Language: Английский

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Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 170 - 170

Published: Feb. 26, 2025

Cancer is a global health concern. Various therapeutic approaches, including chemotherapy, photodynamic therapy, and immunotherapy, have been developed for cancer treatment. Silica nanoparticles, quantum dots, metal–organic framework (MOF)-based nanomedicines gained interest in therapy because of their selective accumulation tumors via the enhanced permeability retention (EPR) effect. However, bare nanoparticles face challenges poor biocompatibility, low stability, limited drug-loading capacity, rapid clearance by reticuloendothelial system (RES). Gels with unique three-dimensional network structures formed through various interactions such as covalent hydrogen bonds are emerging promising materials addressing these challenges. Gel hybridization enhances facilitates controlled drug release, confers cancer-targeting abilities to nanoparticles. This review discusses gel–nanoparticle hybrid systems treatment past five years analyzes roles gels systems.

Language: Английский

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Advancements in Nanotechnology for Targeted and Controlled Drug Delivery in Hematologic Malignancies: Shaping the Future of Targeted Therapeutics

Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(1), P. 16 - 16

Published: March 5, 2025

Hematologic malignancies, including leukemia, lymphoma, and multiple myeloma, pose significant therapeutic challenges due to their heterogeneity high relapse rates. Nanotechnology has emerged as a promising avenue for precision drug delivery in these allowing enhanced concentration at tumor sites reducing systemic toxicity. Recent developments nanocarriers—such liposomes, polymeric nanoparticles, inorganic nanoparticles—have enabled targeted approaches, utilizing molecular markers specific malignant cells increase efficacy while minimizing adverse effects. Evidence from preclinical clinical studies underscores the potential of nanotechnology improve patient outcomes by facilitating controlled release, improved bioavailability, reduced However, translating advancements into practice requires further research validate safety efficacy. This review provides comprehensive analysis latest innovations hematologic addressing current achievements future directions integrating approaches Clinical Hemato-Oncology.

Language: Английский

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Clinical Applications of Targeted Nanomaterials

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 379 - 379

Published: March 17, 2025

Targeted nanomaterials are at the forefront of advancements in nanomedicine due to their unique and versatile properties. These include nanoscale size, shape, surface chemistry, mechanical flexibility, fluorescence, optical behavior, magnetic electronic characteristics, as well biocompatibility biodegradability. attributes enable application across diverse fields, including drug delivery. This review explores fundamental characteristics emphasizes importance clinical applications. It further delves into methodologies for nanoparticle programming alongside discussions on trials case studies. We discussed some promising nanomaterials, such polymeric nanoparticles, carbon-based metallic role biomedical underscores significant translating applications highlights potential these innovative approaches revolutionizing medical field.

Language: Английский

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Pancreatic cancer: failures and hopes—a review of new promising treatment approaches

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: March 18, 2025

Pancreatic cancer is a challenging disease with limited treatment options and high mortality rate. Just few therapy advances have been made in recent years. Tumor microenvironment, immunosuppressive features mutational status represent important obstacles the improvement of survival outcomes. Up to now, first-line did achieve median overall less than 12 months this discouraging data lead clinicians all over world focus their efforts on various fields investigation: 1) sequential cycling different systemic order overcome mechanisms resistance; 2) discovery new predictive bio-markers, target specific patient population; 3) combination treatment, modulate tumor microenvironment pancreatic cancer; 4) modalities delivery drugs pass physical barrier desmoplasia stroma. This review shows future directions strategies advanced through deep analysis these macro areas research.

Language: Английский

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Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 422 - 422

Published: March 26, 2025

Background: Ganoderma lucidum (GL), commonly known as the “Lingzhi” or “Reishi” mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. The unique combination of bioactive compounds present GL, such triterpenoids, polysaccharides, peptides, inspired interest leveraging their therapeutic In recent years, emerging field nanotechnology opened up new possibilities using remarkable GL at nanoscale. Objetive: main objective this review is to explore innovative therapies, particularly cancer treatment, assess how nanotechnology-based strategies can enhance applications.is explore. Results: Nanotechnology-based have investigated efficient extraction purification from GL. Additionally, nanocarriers nanoformulations developed protect these sensitive degradation, ensuring stability during storage transportation. use GL-based nanomaterials shown promising results several biomedical applications, namely due anticancer activity by targeting cells, inducing apoptosis, inhibiting tumor growth. Conclusions: presents an exciting frontier development novel applications. Nevertheless, further research interdisciplinary are warranted fully exploit synergistic offered nanotechnology. Future prospects include robust clinical trials focused on therapies clarify mechanisms actions optimize formulations, ultimately leading solutions human well-being.

Language: Английский

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Lipid-based Nanoparticles: Strategy for Targeted Cancer Therapy

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Lipid-based Nanoparticles (LBNPs) have emerged as a transformative approach in cancer treatment, offering innovative drug delivery solutions that enhance therapeutic efficacy while minimizing adverse effects. By exploring the characterization, classification, synthesis, targeting strategies, and advantages of LBNPs, this study highlights how LBNPs been used to overcome limitations traditional chemotherapy improve patient outcomes. As nanotechnology revolutionizes therapy, emergence promising strategy for targeted has led optimism regarding future treatment. This review extensively assesses structure, categories, production methods, benefits, recent advancements treating cancer. It also current challenges possible directions. is aimed at providing comprehensive understanding LBNPs’ potential therapy. Liposomes, nanostructured lipid carriers, solid nanoparticles, lipid-polymer hybrid nanoparticles are all types each with unique features interest These particles can be synthesized through various procedures, such bulk nanoprecipitation, solvent-based emulsification, or microfluidics. Passive systems, active responsive platforms direct tumors. Consequently, provide an improved release pattern minimizes side effects enhancing efficacy. With combination offer hopeful Continued research expected outcomes overall quality life care.

Language: Английский

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