Mendelian Randomization Analysis of the Relationship between Neurotransmitter-Related Genes and Cancer: Insights from Multi-omics Data
Abstract
Background: Epidemiological
evidence
indicates
a
potential
association
between
mental
disorders
and
cancer.
However,
the
specific
role
of
neurotransmitter-related
genes
(NRG)
in
cancer
development
remains
unclear.
This
study
employs
Mendelian
randomization
with
multi-omics
summary
data
to
explore
causal
effects
underlying
mechanisms
NRG
Materials
Methods:
The
relationships
10
14
types
were
investigated.
was
retrieved
from
GeneCards
database.
Transcriptome
datasets
breast
gathered
Gene
Expression
Omnibus
(GEO).
The
Summary-data-based
Randomization
(SMR)
method
utilized
for
genome-wide
(GWAS)
analysis,
incorporating
expression
quantitative
trait
loci
(eQTLs),
DNA
methylation
QTLs
(mQTLs),
genetic
variants
that
influence
gene
intestines
(intestinal
eQTLs)
composition
fecal
microbiota
(mbQTLs).
Colocation
analysis
performed
identify
links
host
gut
microbiota.
Sensitivity
analyses
conducted
using
two
additional
techniques.
Results:
Mendelian
established
A
meta-analysis
five
identified
821
differentially
expressed
(DEGs)
among
829
non-redundant
genes.
KRTCAP2
as
blood
tissues,
while
SMR
highlighted
cg24674445
significant
site.
inversely
correlated
cancer,
whereas
negatively
affected
expression,
suggesting
positive
on
progression.
Conclusion:
This
found
regulates
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Language: Английский