Promising Cellular Immunotherapy for Colorectal Cancer Using Classical Dendritic Cells and Natural Killer T Cells

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 166 - 166

Published: Jan. 22, 2025

Colorectal cancer (CRC) remains one of the leading causes cancer-related morbidity and mortality around world. Despite advances in surgery, chemotherapy, targeted therapies, prognosis for patients with metastatic or advanced CRC poor. Immunotherapies comprising immune checkpoint inhibitors showed disappointing responses (mCRC). However, cellular immunotherapy, specifically using classical dendritic cells (cDCs), may hold unique promise recognition antigens. cDCs are substantial players instrumental orchestrating innate adaptive by processing presenting tumor antigens to effector cells. Natural killer T (NKT) insufficiently studied but because their ability bridge reactions crosstalk cancer. This review explores therapeutic potential both NKT as a synergistic therapy CRC, focusing on biological roles, strategies harnessing capabilities, clinical applications, challenges within microenvironment. Both can be used new effective approach cell-based therapies cancers provide hope that challenging treat.

Language: Английский

From Adenoma to Carcinoma: Oxidative Stress and Lipidomic Profile in Colorectal Cancer Patients

Journal of Mind and Medical Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 16 - 16

Published: April 8, 2025

Research undertaken over the past few years has brought attention to role of oxidative stress in development neoplasms by damaging nucleic acids, lipids, and proteins, thereby altering their normal function. In general, levels antioxidant enzymes are low patients with neoplasms, biomarkers used quantify have increased levels. Elevated 8-hydroxy-deoxyguanosine (8-OHdG) malondialdehyde (MDA), as well decreased enzymes, been observed diagnosed colorectal cancer (CRC) at various stages evolution, but further research is needed on correlation between these disease progression. Inflammation enhances production reactive oxygen species plays an important CRC development. Studies field metabolomics suggested that changes serum metabolites might be indicators progression from adenoma carcinoma, particularly those resulting lipid metabolism. The lipidomics pathogenesis warrants investigation, combinations (metabolic fingerprints) may potential become clinically useful markers. this article, we review our current understanding interplay stress, inflammatory markers lipidomic products CRC.

Language: Английский

Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1663 - 1663

Published: Oct. 8, 2024

Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer (CRC). We previously reported that synthase (FASN), a key enzyme of de novo synthesis, promotes the initiation and progression CRC. However, mechanisms how upregulation FASN CRC are not completely understood. Here, using

Language: Английский