Advances in nanotechnology for targeting cancer-associated fibroblasts: A review of multi-strategy drug delivery and preclinical insights

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 1, 2025

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting growth, immune evasion, and metastasis. Recently, drug delivery systems targeting CAFs have emerged as promising long-term effective approach to cancer treatment. Advances nanotechnology, particular, led development of nanomedicine designed specifically target CAFs, offering new possibilities for precise personalized therapies. This article reviews recent progress using nanocarriers that CAFs. Additionally, we explore potential combining multiple therapies, such chemotherapy immunotherapy, with enhance efficacy overcome resistance. Although many preclinical studies show promise, clinical application still faces considerable challenges, especially terms penetration large-scale production. Therefore, this review aims provide fresh perspective on CAF-targeted highlight future research directions applications.

Language: Английский

Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189316 - 189316

Published: April 1, 2025

Language: Английский

Single-Cell RNA-Sequencing: Opening New Horizons for Breast Cancer Research

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9482 - 9482

Published: Aug. 31, 2024

Breast cancer is the most prevalent malignant tumor among women with high heterogeneity. Traditional techniques frequently struggle to comprehensively capture intricacy and variety of cellular states interactions within breast cancer. As global precision medicine rapidly advances, single-cell RNA sequencing (scRNA-seq) has become a highly effective technique, revolutionizing research by offering unprecedented insights into heterogeneity complexity This cutting-edge technology facilitates analysis gene expression profiles at level, uncovering diverse cell types microenvironment. By dissecting composition transcriptional signatures cells, scRNA-seq provides new perspectives for understanding mechanisms behind therapy, drug resistance metastasis in In this review, we summarized working principle workflow emphasized major applications discoveries research, highlighting its impact on our comprehension biology potential guiding personalized treatment strategies.

Language: Английский