Serum Antibodies Against the E5 Oncoprotein from Human Papillomavirus Type 16 Are Inversely Associated with the Infection and the Degree of Cervical Lesions DOI Creative Commons
Dolores Azucena Salazar-Piña,

Minerva Maldonado-Gama,

Ana M. Gonzalez-Jaimes

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2699 - 2699

Published: Nov. 26, 2024

Background: The humoral immune response against human papillomavirus (HPV) has been suggested as a source of biomarkers for the early detection cervical cancer (CC). Therefore, we aimed to characterize antibody HPV16 E5 in natural history and determine its usefulness biomarker HPV-associated lesions. Methods: This study was conducted at Cuautla General Hospital, Morelos, Mexico, with women (18 64 years) who agreed participate. Samples were obtained from 335 lesions 150 negative Papanicolaou tests. HPV genotyping performed by PCR pyrosequencing, anti-E5 antibodies detected slot blot. Results: overall prevalence 17.9%, higher observed no lesion (NL, 49.4%) group, downward trend according degree lesion, intraepithelial neoplasia-1 (CIN1, 32.2%) CIN2 (11.5%) CIN3/CC (6.9%). logistic regression model showed associations CIN1 (OR = 0.38), 0.42), 0.32) groups, being statistically significant. Contrast analysis an inverse relationship between DNA 0.35), 0.39), 0.31) groups. Conclusions: These results suggest that could be associated clearance infection without since presence antibodies. In contrast, progression CIN2/CIN3 CC, reversed, disappeared, frequency viral genome increased.

Language: Английский

Cervical cancer: Part I human papilloma virus vaccination in Taiwan DOI Creative Commons

Szu‐Ting Yang,

Peng‐Hui Wang,

Hung‐Hsien Liu

et al.

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(3), P. 320 - 328

Published: May 1, 2024

A significant decline in both incidence and prevalence of cervical cancers after widespread-introducing screening strategy by Papanicolau test (Pap test) has been found the world, but cancer is still one most common female cancers, reporting fourth also leading causes to result main women-associated morbidity mortality, particularly for those women living low- middle-income countries. Cervical important health concerns directly destroying global health-care system, partly because not only increasing disability either secondary diseases themselves victims or mediated treatment-related adverse events survivors acting as a cause death diseased patients worldwide, alarming urgent need do something minimize catastrophic diseases-related heavy socioeconomic burden. It fortunate that preventable disease, based on its strong association with human papillomavirus (HPV) infection (more than 95%), high-risk HPV (HR-HPV) high possibility detecting before development well an effective prevention vaccination. That why WHO (World Health Organization) considers public problem attempts accelerate elimination program three-pillar approach (90:70:90% targets), including (1) 90% girls are fully vaccinated vaccine 15 years age; (2) 70% screened high-performance 35 45 age precancerous lesions treated early; (3) identified receive appropriate adequate treatment. Herein, this review focuses vaccination Part I, recommendations Taiwan government's policy

Language: Английский

Citations

12
CRISPR integrated biosensors: A new paradigm for cancer detection DOI

Ashok Saini,

Neeraj Dilbaghi, Neelam Yadav

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 569, P. 120179 - 120179

Published: Feb. 1, 2025

Language: Английский

Citations

1
Applications of cell therapy in the treatment of virus-associated cancers DOI
Keri Toner, Chase D. McCann, Catherine M. Bollard

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(10), P. 709 - 724

Published: Aug. 19, 2024

Language: Английский

Citations

4
Challenging the status quo: Why artificial intelligence models must go beyond accuracy in cervical cancer diagnosis DOI
Yousry AbdulAzeem, Hossam Magdy Balaha,

Hanaa ZainEldin

et al.

Biomedical Signal Processing and Control, Journal Year: 2025, Volume and Issue: 105, P. 107620 - 107620

Published: Feb. 3, 2025

Language: Английский

Citations

0
HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates DOI Creative Commons
Emilia Włoszek,

Katherine Krupa,

Eliza Skrok

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(3), P. 122 - 122

Published: Feb. 22, 2025

One of the most significant breakthroughs in cancer research has been identification persistent infection with certain human papillomaviruses (HPV) genotypes as cause cervical cancer. Since then, a range diagnostic and therapeutic methods developed based on this discovery. This article aims to describe latest updates biology, prevention, treatment HPV-related The current state knowledge regarding vaccinations, tests, therapies is presented. WHO guidelines vaccinations are presented, well announcements upcoming changes. final part summarizes promising new methods, perspectives findings self-administered use vaccines, circulating cell-free DNA diagnosis. Despite progress made recent years, strategy vaccination testing remains cornerstone fight against

Language: Английский

Citations

0
Basic Knowledge About Cervical Cancer and its Screening Tests Among Secondary School Teachers in Baghdad City DOI Creative Commons
Susan Abed Zaidan

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 215 - 220

Published: March 17, 2025

Background: Cervical cancer is a well-defined and preventable major health problem. The main cause behind it persistent human papillomavirus (HPV) infection. There are more than 200 HPV subtypes, but only minority of them oncogenic. mode transmission this infection by sexual intercourse. It can be prevented regular checking for premalignant states taking cervical smears (Pap smears) vaccinating young girls. In Iraq, there no official policies the preventive measures, personal awareness way to make women seek screening tests or vaccines. Objectives: To explore general information secondary school teachers in Baghdad city/Iraq who college graduates about cancer. Methods: A cross-sectional study was done, including 232 female were interviewed asked fill out written questionnaire. Results: Only 5.6% respondents mentioned viral as cancer, 14.2% answered sexually transmitted disease. 14.7% included recognize smear test. one teacher (0.4%) knows vaccine prevent Teaching material mostly has significant association with teacher’s information. source social media (76.7%). Conclusions: poor knowledge among educated class, teachers, affect rate occurrence disease future. Social used disseminate regarding Iraqi women.

Language: Английский

Citations

0
Oncological outcomes, survival analysis, and failure patterns in patients with resectable squamous cell carcinoma of the oral tongue treated with glossectomy DOI Creative Commons
Hadi Afandi Al-Hakami, Atheer Ali Al-Talhi, Bassam AlRajhi

et al.

The Egyptian Journal of Otolaryngology, Journal Year: 2025, Volume and Issue: 41(1)

Published: March 25, 2025

Abstract Background Oral squamous cell carcinoma (OSCC), particularly of the oral tongue (OTSCC), poses significant challenges due to its aggressive nature and high incidence rates. Treatment options for cancer include surgery, radiation therapy chemotherapy. Single modality or multimodality are made after a multidisciplinary team decision. Surgical intervention is preferable treatment resectable OTSCC, often supplemented with adjuvant therapies improve outcomes. Objective This study systematically evaluates oncological outcomes, survival rates, failure patterns in patients OTSCC treated glossectomy. The aims identify prognostic factors, assess efficacy, understand reasons locoregional recurrence poor Methodology A retrospective analysis 56 who underwent glossectomy between 2010 2021 at King Abdulaziz Medical City was conducted. Data on demographics, clinical characteristics, modalities, outcomes were collected analyzed. Statistical analyses including Kaplan–Meier curves Cox regression employed evaluate recurrence. Results cohort predominantly included OTSCC. interventions varied, proportion receiving therapies. Oncological showed 5-year overall rate 35.7%, notable rates Pathological staging, lymphovascular invasion, perineural invasion emerged as predictors Conclusion Despite advancements strategies, remains challenging modest frequent Early detection, comprehensive tailored approaches crucial improving patient quality life.

Language: Английский

Citations

0
Analysing the Gene Expression Profiles of the Orphan Nuclear Receptors NR4A1, NR4A2 and NR4A3 in Premalignant Lesions of the Cervix and Cervicitis DOI Creative Commons

Rosa P Cruz-Nieves,

Gladys Eloísa Ramírez-Rosales,

Javier González-Ramírez

et al.

European Journal of Obstetrics & Gynecology and Reproductive Biology X, Journal Year: 2024, Volume and Issue: 24, P. 100355 - 100355

Published: Nov. 13, 2024

The main objective of the present study was to evaluate expression nuclear orphan receptors in development Uterine Cervical Cancer (UCC). principal cause dysplastic changes cervical epithelium is presence human papilloma virus leading intraepithelial neoplasia I (CIN I), high-grade lesions II and CIN III) and, finally, invasive cancer. Despite existence various treatments vaccines, there still a high mortality rate. There evidence participation group called orphans diseases, including

Language: Английский

Citations

1
The potential role of HPV oncoproteins in the PD-L1/PD-1 pathway in cervical cancer: new perspectives on cervical cancer immunotherapy DOI Creative Commons
Jin Li, Yuhong Ma, Qing-Feng Wu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 13, 2024

Cervical cancer (CC) is a common malignant tumour of the female reproductive system that highly harmful to women’s health. The efficacy traditional surgery, radiotherapy and chemotherapy limited, especially for recurrent metastatic CC. With continuous progress in diagnostic treatment technology, immunotherapy has become new approach treating CC therapy However, not effective all patients with Therefore, factors related have focus researchers. High-risk human papillomavirus (HPV) infection an important factor drives development affects its progression prognosis. Increasing attention been given mechanism E5, E6 E7 proteins, which are encoded by HPV gene, occurrence their interaction programmed cell death ligand-1/programmed death-1 (PD-L1/PD-1). Although some preliminary studies conducted on these topics, comprehensive systematic review topics available. This comprehensively summarizes articles from journals impact greater than 3 published past 5 years; it also reviews CC, PD-L1/PD-1 axis regulation between HPV-related oncoproteins pathway prognosis study provides theoretical support use immunotherapies basis selection specific medications target different perspective discovery targets

Language: Английский

Citations

1
Syringin: plant source, traditional uses, anti‐cancer, brain protection and related pharmacological properties DOI
Chuan Liu, Huijuan Xu, Peng Wang

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Traditional herbal medicines, containing syringin in different parts of the world, have been used to enhance memory, relieve pain, cough, clear fever, treat psoas tension, tonsillitis, sore throat, acute gastroenteritis, and anti‐inflammatory, analgesic, so on. In this article, extraction, analytical method, pharmacological action, research progress syringin‐containing plants were reviewed. Various extraction methods detection summarized, especially ultrasonic‐assisted high‐performance liquid chromatography, which recommended for determination syringin. We spotlighted anti‐cancer, brain‐protective, anti‐inflammatory effects An in‐depth analysis four contains syringin— Eleutherococcus senticosus , Codonopsis pilosula Daphne tangutica Maxim, Syringa reticulata subsp. amurensis . addition, safety efficacy these preparations (Shugan Jieyu Capsule, compound Coginseng tablet, hyoscyamine ointment, Qinfenghong Zhike capsule) analyzed. Although has widely traditional medicine, its specific mechanism action clinical are still not completely understood, further is needed explore verify it. This study provides a valuable theoretical basis potential direction development new drugs such as anti‐cancer brain protection.

Language: Английский

Citations

0