
Langenbeck s Archives of Surgery, Journal Year: 2025, Volume and Issue: 410(1)
Published: March 31, 2025
Pancreatoduodenectomy (PD) is a complex surgery with high rate of postoperative complications, for which effective preoperative indicators are currently lacking. Inflammatory indices such as the pan-immune-inflammation value (PIV), platelet-neutrophil product (PPN), and platelet-albumin ratio (PAR) have shown potential biomarkers prognosis in various cancers. However, their predictive complications open-PD (OPD) patients remains underexplored. This study aims to investigate relationship between these inflammatory identify new biomarkers, provide theoretical basis improving perioperative management OPD patients. We analyzed data from 309 who underwent (OPD). Six indices-platelet-to-lymphocyte (PLR), PIV, PPN, PAR, neutrophil-to-HDL (NHR), neutrophil-albumin (NAR)-were assessed association using logistic regression restricted cubic spline analysis. Predictive performance was evaluated ROC curves decision curve PLR, PPN were significantly linked most outcomes had good performance. NHR associated severe complications. PAR effectively predicted hemorrhage (AUC = 0.684) delayed gastric emptying (DGE) 0.701). Combining enhanced accuracy. key patients, also useful predicting like DGE.
Language: Английский