IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Long non-coding RNAs (LncRNAs) are that do not code for proteins and were thus earlier known as Junk RNAs. Recently, LncRNAs have emerged critical regulators in the expression of coding genes various important biological signaling pathways, controlling crucial developmental processes. Reports association with several diseases including cancer also been implicated. play a diverse role regulating influencing tumorigenesis, progression, metastasis. They can function both oncogenes or tumor suppressors, modulating key pathways cellular Mutation epigenetic-induced aberrant dysregulates different essential leading to malignant phenotype hallmarks types cancer. Tumor cells secrete specific endogenous into fluids depending on type, giving rise stable circulating LncRNAs, proving be great potential non-invasive minimally invasive diagnostic biomarkers. In this chapter, we explore multifaceted roles types, highlighting their diagnostic/prognostic biomarkers therapeutic targets. Additionally, discuss innovative strategies targeting treatment, RNA interference CRISPR technology. This chapter will provide comprehensive overview LncRNAs’ implications research personalized medicine.
Language: Английский