Plasma proteins mediate the effects of the gut microbiota on the development of head and neck cancer: a two-sample and mediated Mendelian randomized study DOI Creative Commons
Jianyu Rao, Wenda Zhang, Chenyu Zha

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Although previous observational studies have highlighted a possible association between the gut microbiota (GM) and head neck cancer (HNC), causal relationships remain unclear, particularly regarding role of plasma proteins as potential mediators. Clarifying these connections is essential for uncovering underlying mechanisms HNC progression may lead to new therapeutic strategies. First, we examined link GM via two-sample Mendelian randomization (MR) approach. We then investigated causative same MR technique. The coefficient product approach was used clarify in pathway HNC. Finally, sensitivity investigations were performed assess robustness coherence results. analyses revealed protective effects one family six genera on (Lachnospiraceae, Parabacteroides, Phascolarctobacterium, Alistipes, Sutterella, Roseburia Alloprevotella). In contrast, three (Ruminococcus, Prevotella Bacteroides) significantly positively associated with risk. Through further examination, researchers discovered 18 that relationship Notably, mediation illustrated effect OTU97_86 (Phascolarctobacterium) (total IVW: OR = 0.879, 95% 0.810–0.954, p 0.002) mediated by Proteasome subunit alpha type-1 (PSMA1) (− 0.020, CI − 0.039 ~ 0.001, 0.036), accounting 15.25% total effect. Similarly, OTU99_35 (Ruminococcus) risk 1.109, 1.027–1.198, 0.008) protein FAM107B (0.015, 0.001–0.029, 0.031), 14.69% analysis specific GMs influence through proteins: Phascolarctobacterium protects against PSMA1, whereas Ruminococcus increases FAM107B. These pathways suggest preventative factor factor. This highlights possibility using biomarkers or targets prevention, diagnosis, treatment.

Language: Английский

Exploring the gut microbiome and head and neck cancer interplay DOI

Veeksha V Shetty,

Shilpa S. Shetty

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155603 - 155603

Published: Sept. 28, 2024

Language: Английский

Citations

4
Plasma proteins mediate the effects of the gut microbiota on the development of head and neck cancer: a two-sample and mediated Mendelian randomized study DOI Creative Commons
Jianyu Rao, Wenda Zhang, Chenyu Zha

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Although previous observational studies have highlighted a possible association between the gut microbiota (GM) and head neck cancer (HNC), causal relationships remain unclear, particularly regarding role of plasma proteins as potential mediators. Clarifying these connections is essential for uncovering underlying mechanisms HNC progression may lead to new therapeutic strategies. First, we examined link GM via two-sample Mendelian randomization (MR) approach. We then investigated causative same MR technique. The coefficient product approach was used clarify in pathway HNC. Finally, sensitivity investigations were performed assess robustness coherence results. analyses revealed protective effects one family six genera on (Lachnospiraceae, Parabacteroides, Phascolarctobacterium, Alistipes, Sutterella, Roseburia Alloprevotella). In contrast, three (Ruminococcus, Prevotella Bacteroides) significantly positively associated with risk. Through further examination, researchers discovered 18 that relationship Notably, mediation illustrated effect OTU97_86 (Phascolarctobacterium) (total IVW: OR = 0.879, 95% 0.810–0.954, p 0.002) mediated by Proteasome subunit alpha type-1 (PSMA1) (− 0.020, CI − 0.039 ~ 0.001, 0.036), accounting 15.25% total effect. Similarly, OTU99_35 (Ruminococcus) risk 1.109, 1.027–1.198, 0.008) protein FAM107B (0.015, 0.001–0.029, 0.031), 14.69% analysis specific GMs influence through proteins: Phascolarctobacterium protects against PSMA1, whereas Ruminococcus increases FAM107B. These pathways suggest preventative factor factor. This highlights possibility using biomarkers or targets prevention, diagnosis, treatment.

Language: Английский

Citations

0