Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Abstract Autodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and delivery have hindered its clinical translation owing induction of adverse effects cytotoxicity in healthy In this study, a novel approach auto‐initiated dynamic conjugating zwitterionic near‐infrared fluorophores cell‐penetrating peptide is proposed. This enables efficient cellular uptake specific targeting desired cells while avoiding off‐target uptake. The bioconjugate causes cancer‐specific toxicity following internalization into cells, triggered intracellular conditions lysosomes. innovative selective lysosomes malignant minimizing cytotoxic on normal By lysosomes, method overcomes inherent risks side associated with conventional treatments, offering effective therapy.

Language: Английский