Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 30, 2025

Abstract Recent advances in oncology research have highlighted the promising synergy between low-dose radiation therapy (LDRT) and immunotherapies, with growing evidence highlighting unique benefits of combination. LDRT has emerged as a potent tool for stimulating immune system, triggering systemic antitumor effects by remodeling tumor microenvironment. Notably, demonstrates remarkable efficacy even challenging metastatic sites such liver ( uveal ) brain cutaneous ), particularly advanced melanoma stages. The increasing interest utilizing secondary uveal, mucosal, or melanomas underscores its potential combination various immunotherapies. This comprehensive review traverses journey from laboratory to clinical applications, elucidating LDRT’s immunomodulatory role on microenvironment (TIME) responses. We meticulously examine preclinical ongoing trials, throwing light prospects complementary treatment. Furthermore, we explore challenges associated integration into therapies, addressing crucial factors optimal dosage, fractionation, treatment frequency, other pharmacological agents. Considering low toxicity profile, presents compelling case application across multiple lesions, augmenting response poly-metastatic disease scenarios. convergence disciplines holds immense developing novel radiotherapy-combined modalities, paving way more effective personalized strategies beyond. Moreover, dose-related toxicities immunotherapies may be reduced synergistic amplification LDRT.

Language: Английский

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Nanoparticle-based Traditional Chinese Medicine for Immunotherapy in Gastrointestinal Tumors

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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CAR T cell therapies in gastrointestinal cancers: current clinical trials and strategies to overcome challenges

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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