OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking DOI Creative Commons

Watcharapong Panthong,

Chamsai Pientong,

Thawaree Nukpook

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1089 - 1089

Published: Dec. 23, 2024

Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms potential therapeutic drugs have not been fully elucidated. This study investigated the key molecular hub proteins involved in using proteomics bioinformatic analysis. Dysregulated were validated by RT-qPCR nasal polyp (NP) tissues. Proteomic analysis revealed that differentially expressed clustered MCODE scores ≥ 4 into three modules. The specific each module analyzed pathways STRING, highlighting of histone modification spliceosome dysregulation. Spliceosome components SNRNP200 SF3A3 significantly downregulated RT-qPCR. Web-based applications L1000CDS2 iLINCS applied to identify 10 repurposable could reverse gene expression pattern associated SNSCC. Docking studies TAF1, protein modification, these small molecule inhibitors indicated OSI-027 be most promising due its strong binding interactions residues. These findings suggest underlying mechanism may serve as valuable targets for drug development, emerging novel candidate against TAF1

Language: Английский

Mechanisms and technologies in cancer epigenetics DOI Creative Commons
Zaki A. Sherif, Olorunseun O. Ogunwobi, Habtom W. Ressom

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 7, 2025

Cancer's epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling complex interplay between DNA methylation, histone chromatin remodeling, non-coding RNAs. We navigate through tumultuous seas dysregulation, exploring how these processes conspire to silence tumor suppressors unleash oncogenic potential. The narrative pivots cutting-edge technologies, revolutionizing our ability decode epigenome. From granular insights single-cell epigenomics holistic view offered by multi-omics approaches, we examine tools are reshaping understanding heterogeneity evolution. also highlights emerging techniques, such as spatial long-read sequencing, which promise unveil hidden dimensions regulation. Finally, probed transformative potential CRISPR-based epigenome editing computational analysis transmute raw data into biological insights. study seeks synthesize comprehensive yet nuanced contemporary landscape future directions research.

Language: Английский

Citations

0
OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking DOI Creative Commons

Watcharapong Panthong,

Chamsai Pientong,

Thawaree Nukpook

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1089 - 1089

Published: Dec. 23, 2024

Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms potential therapeutic drugs have not been fully elucidated. This study investigated the key molecular hub proteins involved in using proteomics bioinformatic analysis. Dysregulated were validated by RT-qPCR nasal polyp (NP) tissues. Proteomic analysis revealed that differentially expressed clustered MCODE scores ≥ 4 into three modules. The specific each module analyzed pathways STRING, highlighting of histone modification spliceosome dysregulation. Spliceosome components SNRNP200 SF3A3 significantly downregulated RT-qPCR. Web-based applications L1000CDS2 iLINCS applied to identify 10 repurposable could reverse gene expression pattern associated SNSCC. Docking studies TAF1, protein modification, these small molecule inhibitors indicated OSI-027 be most promising due its strong binding interactions residues. These findings suggest underlying mechanism may serve as valuable targets for drug development, emerging novel candidate against TAF1

Language: Английский

Citations

0