International Journal of Polymeric Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9
Published: April 29, 2025
Language: Английский
Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 136, P. 108958 - 108958
Published: Jan. 22, 2025
Language: Английский
Citations
4
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: Feb. 26, 2025
Abstract Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging age-related lung diseases such as chronic obstructive disease idiopathic fibrosis cancer. HIF plays a pivotal role cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, inflammation. Meanwhile, leads irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes inflammation, tissue remodeling, fibrosis. Dysregulation of these pathways accelerates progression by promoting oxidative stress, mitochondrial dysfunction, epigenetic alterations. Recent studies indicate that interact at multiple levels, where can both induce suppress senescence, depending on conditions. While transient activation supports repair stress resistance, dysregulation exacerbates pathologies. Furthermore, emerging evidence suggests targeting could offer new therapeutic strategies mitigate diseases. This review explores intricate crosstalk between mechanisms, shedding light how their interplay influences progression. Additionally, we discuss potential interventions, including senolytic therapies modulators, enhance health longevity.
Language: Английский
Citations
2
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 11, 2025
Language: Английский
Citations
2
Hereditas, Journal Year: 2025, Volume and Issue: 162(1)
Published: March 24, 2025
Abstract Diffuse large B-cell lymphoma (DLBC) is the most common subtype of non-Hodgkin lymphoma, characterized by its aggressive nature and poor prognosis in advanced stages. Despite advances treatment, molecular mechanisms driving DLBC progression remain incompletely understood, necessitating identification novel biomarkers for diagnosis prognosis. In this study, we analyzed two publicly available datasets (GSE32018 GSE56315) from Gene Expression Omnibus database (GEO) to identify overlapping differentially expressed genes (DEGs). Later on, a comprehensive silico vitro methodology was adopted decipher role DEGs DLBC. analysis GSE32018 GSE56315 identified five gene: SP3, CSNK1A1, STYX, SIRT5, MGEA5. validation using GEPIA2 confirmed upregulation downregulation MGEA5 tissues compared normal controls. Furthermore, mutational revealed that CSNK1A1 only gene among these exhibit mutations, with 2.7% mutation frequency patients. Methylation highlighted negative correlation between methylation levels mRNA expression, while survival high STYX expression as significantly associated poorer overall Functional assays demonstrated knockdown U2932 cells led reduced cell proliferation, colony formation, enhanced wound healing, indicating STYX’s pivotal migration. Additionally, enrichment involvement key biological processes, including intracellular trafficking myeloid progenitor differentiation. These findings emphasize potential therapeutic targets DLBC, particularly highlighting promising prognostic marker target intervention.
Language: Английский
Citations
1
Journal of Microencapsulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27
Published: Feb. 24, 2025
Gadolinium (Gd) nanoparticles hold significant promise in medical theranostics due to their unique properties. This review outlines the synthesis, characterisation, and applications of Gd nanostructures combating microbial threats advancing cancer theragnostic strategies. Synthesis methods such as co-precipitation, microemulsion, laser ablation are discussed, alongside TEM, SEM, magnetic characterisation. The antimicrobial efficacy nanostructures, potential combination therapy, promising anticancer mechanisms explored. Biocompatibility, toxicity, regulatory considerations also evaluated. Challenges, future perspectives, emerging trends nanostructure research highlighted, emphasising transformative applications.
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123454 - 123454
Published: Feb. 27, 2025
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120215 - 120215
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123597 - 123597
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)
Published: March 1, 2025
ABSTRACT Oral squamous cell carcinoma (OSCC) is experiencing a progressive increase in global incidence. Regrettably, this entity typically discovered at an advanced stage the majority of patients, which indicates increased therapeutic challenges and poorer prognosis. Programmed death protein 1 (PD‐1) appears to have significant role immunotherapy monoclonal antibodies targeting molecule been utilized as intervention. A decade research that neoadjuvant has garnered greater interest than adjuvant OSCC. This may be due serving preventive adjunctive treatment. Enhanced outcomes achieved by optimizing cancer microenvironment before surgery. Of note, introduced preoperatively for untreated
Language: Английский
Citations
0
Transition Metal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Language: Английский
Citations
0