Development of magnetically retrievable nanostructure Pd catalyst supported over magnetic nanocomposite assisted by Strawberry fruit extract and its application in the Suzuki-Miyaura coupling reaction and anti-colorectal, anti-gastric, and anti-pancreatic cancer effects

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123616 - 123616

Published: March 1, 2025

Language: Английский

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Prunin: An Emerging Anticancer Flavonoid

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678

Published: March 16, 2025

Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.

Language: Английский

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Improved cancer detection through feature selection using the binary Al Biruni Earth radius algorithm

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 19, 2025

With the advancement of medical technology, a large amount complex data on cancers is produced for diagnosing and treating cancers. However, not all this useful, as many features are redundant or irrelevant, which can reduce accuracy machine learning models. Metaheuristic algorithms have been employed to select address issue. Although efficacy these has demonstrated, challenges related scalability efficiency persist when handling datasets. In study, binary version Advanced Al-Biruni Earth Radius (bABER) algorithm proposed intelligent removal unnecessary identifying most essential cancer detection. Unlike traditional methods that rely single approach, bABER evaluated using seven datasets compared with eight widely used metaheuristic algorithms, including bSC, bPSO, bWAO, bGWO, bMVO, bSBO, bFA, bGA. Statistical tests such ANOVA Wilcoxon signed-rank test conducted ensure thorough performance assessment. The results indicate significantly outperforms other methods, making it valuable tool improving diagnosis. By refining feature selection, approach enhances existing models, leading more accurate reliable predictions. This study contributes improved data-driven decision-making in healthcare, bringing field closer faster precise

Language: Английский

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Current Research in Drug-Free Cancer Therapies

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 341 - 341

Published: March 26, 2025

Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.

Language: Английский

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A novel label-free electrochemiluminescence immunosensor for oral cancer marker monitoring based on luminol-functionalized PPy/AgNPs nanocomposite

Alexandria Engineering Journal, Journal Year: 2025, Volume and Issue: 123, P. 610 - 619

Published: March 30, 2025

Language: Английский

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CAR T Cells in Lung Cancer: Targeting Tumor-Associated Antigens to Revolutionize Immunotherapy

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155947 - 155947

Published: March 1, 2025

Language: Английский

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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 303 - 318

Published: April 5, 2025

Language: Английский

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Roles of anoikis in hepatocellular carcinoma therapy and the assessment of anoikis-regulatory molecules as therapeutic targets

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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Targeting KRAS-G12C in Lung Cancer: The Emerging Role of PROTACs in Overcoming Resistance

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155954 - 155954

Published: April 1, 2025

Language: Английский

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Advanced synthesis and biomedical applications of colloidal quantum dots: Innovations in Imaging, drug delivery, and theranostics

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114533 - 114533

Published: April 1, 2025

Language: Английский

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