Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications DOI Open Access

Roman Beňačka,

Daniela Szabóová,

Zuzana Guľašová

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 127 - 127

Published: Dec. 26, 2024

Breast cancer (BC) is one of the most prevalent forms globally, and has recently become leading cause cancer-related mortality in women. BC a heterogeneous disease comprising various histopathological molecular subtypes with differing levels malignancy, each patient an individual prognosis. Etiology pathogenesis are complex involve considerable number genetic alterations dozens non-coding RNA expression. Non-coding RNAs part abundant family single-stranded molecules acting as key regulators DNA replication, mRNA processing translation, cell differentiation, growth, overall genomic stability. In context breast cancer, involved cycle control tumor migration invasion, well treatment resistance. Alterations expression may contribute to development progression making them promising biomarkers targets for novel therapeutic approaches. Currently, use not yet been applied routine practice; however, their potential very studied. The present review literature overview current knowledge its objective delineate function diverse classes particular emphasis on utility diagnostic prognostic markers or tools.

Language: Английский

Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications DOI Open Access

Roman Beňačka,

Daniela Szabóová,

Zuzana Guľašová

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 127 - 127

Published: Dec. 26, 2024

Breast cancer (BC) is one of the most prevalent forms globally, and has recently become leading cause cancer-related mortality in women. BC a heterogeneous disease comprising various histopathological molecular subtypes with differing levels malignancy, each patient an individual prognosis. Etiology pathogenesis are complex involve considerable number genetic alterations dozens non-coding RNA expression. Non-coding RNAs part abundant family single-stranded molecules acting as key regulators DNA replication, mRNA processing translation, cell differentiation, growth, overall genomic stability. In context breast cancer, involved cycle control tumor migration invasion, well treatment resistance. Alterations expression may contribute to development progression making them promising biomarkers targets for novel therapeutic approaches. Currently, use not yet been applied routine practice; however, their potential very studied. The present review literature overview current knowledge its objective delineate function diverse classes particular emphasis on utility diagnostic prognostic markers or tools.

Language: Английский

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