Harnessing the Role of ESR1 in Breast Cancer: Correlation with microRNA, lncRNA, and Methylation DOI Open Access
Shengping Yang, Claudio Manna, Pulak R. Manna

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3101 - 3101

Published: March 27, 2025

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that encoded by gene 1 (ESR1), which modulates signaling. ESR1, facilitating overproduction, plays an indispensable role in progression survival of majority BCs. To obtain molecular insights into these phenomena, we analyzed The Cancer Genome Atlas (TCGA) breast invasive carcinoma (BRCA) RNA-Seq datasets for expression ESR1 its correlation to microRNAs (miRNAs) long non-coding RNAs (lncRNAs), along with methylation patterns. Regulation was also assessed total 43 cancerous non-cancerous cell lines. Analyses both TCGA BRCA line data revealed specific lncRNAs, i.e., MEG3, BIK, MLL, FAS are negatively correlated PARP1 demonstrates positive association. Additionally, miR-30a miR-145 showed negative correlations expression. Of 54 loci analyzed, them exhibited expression, highlighting potentially modifiable regulatory mechanism. These findings underscore complex events influencing interaction diverse signaling pathways, demonstrating novel pathogenesis potential therapeutics.

Language: Английский

Long Non-Coding RNAs in Stem Cell Regulation and Regenerative Medicine: Stemness, Differentiation, and Therapeutic Innovation DOI Creative Commons

Melika Emarati,

Hossein Azizi, Nima Ghasemi

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Long non-coding RNAs (lncRNAs) have emerged as critical regulators in stem cell biology, influencing cellular functions such pluripotency, differentiation, and self-renewal. Their unique ability to modulate gene expression at multiple levels—epigenetic, transcriptional, post-transcriptional—makes lncRNAs powerful tools for controlling fate. In regenerative medicine, understanding the roles of specific can enhance therapeutic approaches, particularly cell-based tissue repair engineering. By modulating lncRNA activity, researchers potentially direct differentiation toward desired lineages, facilitating development functional tissues clinical applications. This chapter explores how influence states, highlights current research therapies, discusses potential future applications where lncRNA-based interventions could drive advancements engineering medicine.

Language: Английский

Citations

0
Harnessing the Role of ESR1 in Breast Cancer: Correlation with microRNA, lncRNA, and Methylation DOI Open Access
Shengping Yang, Claudio Manna, Pulak R. Manna

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3101 - 3101

Published: March 27, 2025

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that encoded by gene 1 (ESR1), which modulates signaling. ESR1, facilitating overproduction, plays an indispensable role in progression survival of majority BCs. To obtain molecular insights into these phenomena, we analyzed The Cancer Genome Atlas (TCGA) breast invasive carcinoma (BRCA) RNA-Seq datasets for expression ESR1 its correlation to microRNAs (miRNAs) long non-coding RNAs (lncRNAs), along with methylation patterns. Regulation was also assessed total 43 cancerous non-cancerous cell lines. Analyses both TCGA BRCA line data revealed specific lncRNAs, i.e., MEG3, BIK, MLL, FAS are negatively correlated PARP1 demonstrates positive association. Additionally, miR-30a miR-145 showed negative correlations expression. Of 54 loci analyzed, them exhibited expression, highlighting potentially modifiable regulatory mechanism. These findings underscore complex events influencing interaction diverse signaling pathways, demonstrating novel pathogenesis potential therapeutics.

Language: Английский

Citations

0