Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review DOI Creative Commons

Andreea Smeu,

Iasmina Marcovici, Cristina Dehelean

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 231 - 231

Published: Feb. 8, 2025

Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.

Language: Английский

Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review DOI Creative Commons

Andreea Smeu,

Iasmina Marcovici, Cristina Dehelean

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 231 - 231

Published: Feb. 8, 2025

Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.

Language: Английский

Citations

0