Roles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma DOI Creative Commons

Ruyuan Liu,

Huanyu Cui,

Di Li

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 2493 - 2504

Published: Dec. 1, 2024

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, characterized by a poor prognosis. In recent decades, both incidence and mortality rates of HCC have risen sharply. Sorafenib has emerged as first conventional drug approved US Food Drug Administration for first-line treatment in advanced patients due to its favorable safety profile. However, effectiveness severely hindered acquired resistance, which leads only approximately 30% benefited from sorafenib therapy. resistance involves various mechanisms that inhibit cellular uptake iron reactive oxygen species (ROS). Consequently, ferroptosis novel form cell death contingent upon accumulation intracellular ROS plays critical role mediating through Hippo YAP pathway or Keap1-Nrf2 system. This review aimed comprehensively elucidate underlying HCC, particularly focusing on pathways, provide valuable insights into targeting pathways sorafenib-resistant treatment.

Language: Английский

Novel Insight into the Role of Src Family Kinases in Hepatocellular Carcinoma and Therapeutic Potential DOI

Zhao Yunlong,

Letian Xie,

Binwei Liu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151970 - 151970

Published: May 1, 2025

Language: Английский

Citations

0
Roles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma DOI Creative Commons

Ruyuan Liu,

Huanyu Cui,

Di Li

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 2493 - 2504

Published: Dec. 1, 2024

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, characterized by a poor prognosis. In recent decades, both incidence and mortality rates of HCC have risen sharply. Sorafenib has emerged as first conventional drug approved US Food Drug Administration for first-line treatment in advanced patients due to its favorable safety profile. However, effectiveness severely hindered acquired resistance, which leads only approximately 30% benefited from sorafenib therapy. resistance involves various mechanisms that inhibit cellular uptake iron reactive oxygen species (ROS). Consequently, ferroptosis novel form cell death contingent upon accumulation intracellular ROS plays critical role mediating through Hippo YAP pathway or Keap1-Nrf2 system. This review aimed comprehensively elucidate underlying HCC, particularly focusing on pathways, provide valuable insights into targeting pathways sorafenib-resistant treatment.

Language: Английский

Citations

2