Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Language: Английский
Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Language: Английский
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 270, P. 156001 - 156001
Published: May 10, 2025
Language: Английский
Citations
1ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(2), P. 222 - 223
Published: Jan. 29, 2025
The development of targeted protein degraders offers novel strategies for treating cancer and chronic viral infections. This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, substituted oxazolone compounds targeting IKZF1–4 transcription factors. These demonstrate exceptional efficacy in degrading pathogenic proteins, reprogramming immune responses, facilitating tumor immunity. dual approach underscores the potential cellular degradation systems precision medicine.
Language: Английский
Citations
0Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Language: Английский
Citations
0