Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases DOI Creative Commons
Dario Rusciano

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1957 - 1957

Published: Nov. 27, 2024

This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), diabetic retinopathy. EGCG, potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, neuroprotective effects, making it promising candidate for reducing oxidative stress inflammation ocular tissues. Forskolin, diterpene Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) provides neuroprotection. Both compounds target critical pathways involved disease progression, including stress, mitochondrial dysfunction, inflammation, offering complementary benefits. consolidates preclinical clinical studies, highlighting EGCG as adjunctive or alternative treatments diseases. Future research should explore synergistic effects these compounds, particularly combination therapies aimed at addressing multiple pathogenic mechanisms health.

Language: Английский

Is Multiwavelength Photobiomodulation Effective and Safe for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis DOI Creative Commons
Kuo-Su Chen, Helena Lee,

Hoi-Chun Chan

et al.

Ophthalmology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

This systematic review and meta-analysis compares the complications effects of photobiomodulation (PBM) therapy with sham treatment in patients age-related macular degeneration (AMD). AMD is a leading cause visual impairment older adults, current treatments primarily focusing on symptom management. PBM emerging as potential intervention to improve clinical anatomical outcomes AMD, necessitating comparative analysis determine its efficacy safety. A search was conducted across PubMed/Medline, Google Scholar Cochrane Library from inception January 13, 2025. Randomised controlled trials (RCTs) meeting predefined inclusion criteria were selected. Meta-analysis employed random-effects models. The risk bias included studies assessed using tools. total six studies, comprising 360 477 eyes, focused for dry AMD. Five eligible meta-analysis. Best-corrected acuity (BCVA) showed no significant improvement (SMD − 0.30, 95% CI 0.85 0.26, p = 0.30), high heterogeneity (I2 83%). Macular drusen volume also change 0.08, 0.52 0.37, 0.74), moderate 48%). single study reported effect geographic atrophy 0.28, 1.26 0.71, 0.58). Central subfield thickness 0.11, 0.25 0.47, 0.58) microperimetry 0.02, 0.48 0.44, 0.94) changes. adverse events indicated statistically increase group within 6 months (RR 0.48, 0.29–0.82, 0.007), while overall non-significant 1.04, 0.51–2.12, 0.91, I2 78%). Qualitative suggested that might enhance quality life compared treatment. suggests that, date, there are benefits Further long-term needed establish relevance safety profile.

Language: Английский

Citations

1
Effect of Photobiomodulation on Proliferative Changes in the Retina: Evidence from an In Vitro Model of PVR DOI
Oliver J. Watson, Riemke Aggio‐Bruce, Rohan W. Essex

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 195 - 200

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficiency ophthalmochromotherapy in the complex treatment of patients with computer vision syndrome DOI Open Access
I. G. Ovechkin, Darya A. Shavshina, E. I. Belikova

et al.

Ophthalmology Reports, Journal Year: 2025, Volume and Issue: 18(1), P. 55 - 62

Published: April 4, 2025

BACKGROUND: One of the leading principles asthenopia treatment is a comprehensive approach based on multidirectional methods physical impact organ vision. This provision determines relevance considering ophthalmochromotherapy, use which determined from position photobiomodulation as non-thermal biological process activated by certain wavelengths light. AIM: To evaluate clinical efficacy ophthalmochromotherapy in complex rehabilitation patients with computer vision syndrome. MATERIALS AND METHODS: The study involved 132 syndrome, accompanied characteristic manifestations accommodative — habitual excessive tension accommodation (HETА) or asthenic form (AFAA). Patients were divided into four groups two control groups, underwent traditional method treating and main which, along method, (green color for HETА red AFAA, respectively). RESULTS: A significantly higher level restorative was established when included confirmed more pronounced dynamics indices (p 0.01), contrast sensitivity at low (0.5, 1.0 cycles/deg.) frequencies critical frequency fusion flickering 0.05), quality life 0.01). CONCLUSIONS: syndrome symptoms may be considered an effective correction functional state visual analyzer, (in comparison method) pronounced, statistically significant improvement system eye, well reflecting “sensory” fatigue patient’s life. At same time, accordance standardization, inclusion ensured achievement standard indicators life, reflects full targets perspective “medical social” health model.

Language: Английский

Citations

0
Evaluating the Preclinical Efficacy of Photobiomodulation in Alleviating Neuropathic Corneal Pain: A Behavioral Study DOI Creative Commons

Mohd. Afzal Khan,

Gehan Fatima,

Akm Ashiquzzaman

et al.

Ophthalmology Science, Journal Year: 2024, Volume and Issue: unknown, P. 100680 - 100680

Published: Dec. 1, 2024

Language: Английский

Citations

1
Prolonged Photobiomodulation with Deep Red Light Mitigates Incipient Retinal Deterioration in a Mouse Model of Type 2 Diabetes DOI Open Access
Gabriela Opazo, Felipe Tapia, Alejandra Díaz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12128 - 12128

Published: Nov. 12, 2024

Diabetic retinopathy is a prevalent complication of type 2 diabetes mellitus, characterized by progressive damage to the retinal structure and function. Photobiomodulation therapy, using red or near-infrared light, has been proposed as non-invasive intervention mitigate damage, but tested generally with short-term stimuli. This study aimed evaluate effects prolonged photobiomodulation deep light on function in mouse model. Transgenic LepRdb/J (db/db) mice were exposed therapy via LED devices emitting 654 nm for 12 h daily over ten weeks compared untreated mice. Retinal was evaluated flash electroretinography, while structural changes assessed through histology immunohistochemistry detect astro- microgliosis. At 33 age, db/db obese severely diabetic, exhibited only incipient indicators deterioration. Electroretinogram b-wave peak latencies at intermediate intensities, outer plexiform layer displayed significantly elevated IBA1 expression. prevented these two markers early deterioration had no effect other morphological functional parameters. well-tolerated maintains potential complementary treatment option diabetic requires further optimization therapeutic settings combinatory approaches.

Language: Английский

Citations

0
Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases DOI Creative Commons
Dario Rusciano

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1957 - 1957

Published: Nov. 27, 2024

This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), diabetic retinopathy. EGCG, potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, neuroprotective effects, making it promising candidate for reducing oxidative stress inflammation ocular tissues. Forskolin, diterpene Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) provides neuroprotection. Both compounds target critical pathways involved disease progression, including stress, mitochondrial dysfunction, inflammation, offering complementary benefits. consolidates preclinical clinical studies, highlighting EGCG as adjunctive or alternative treatments diseases. Future research should explore synergistic effects these compounds, particularly combination therapies aimed at addressing multiple pathogenic mechanisms health.

Language: Английский

Citations

0