The influence of increased protein intake and L-carnitine supply on the outcomes of term newborns in intensive therapy DOI Creative Commons
І. О. Анікін, L. S. Stryzhak

Pathologia, Journal Year: 2023, Volume and Issue: 20(3), P. 271 - 280

Published: Dec. 22, 2023

We studied the possibilities of increased protein and L-carnitine supplementation in full-term newborns with perinatal diseases to improve results intensive care. Aim: assess impact short-term consumption by on main indicators treatment effectiveness care unit. Materials methods. To check proposed method feeding newborns, life 59 children, who were randomly divided into two groups, studied. The first group (n = 30) received standard nutrition mother’s milk or formula, second 29) a food product fortified supplement subsidy during hospital stay. Results. Infants both groups had statistically equivalent anthropometric characteristics at beginning study. proportions infants sexes within 50 % percentile. Starting from third week, caloric intake for diet (SG) enrichment (FG), respectively, was 111.83 ± 7.19 kcal/kg/day, against 113.44 5.61 p 0.0667. Per 1 g protein, children FG amount non-protein calories as 28.68 (27.50; 29.80) compared indicator SG 42.37 (41.60; 38.00) U 28.0000; 0.0001. Carnitine led an increase level free carnitine last blood plasma samples, before discharged home. In general, strategy accompanied better physical development probable faster recovery body weight fortification group. Thus, generalized 3966.90 439.08 g, 3554.62 452.28 0.0033. consumed more transferred unit earlier – 12.00 (11.00; 16.00) days, 10.00 (8.00; 12.00) 235,00; 0.0024; previously 26.50 (22.00; 31.00) 21.00 (19.00; 27.00) 267.00, 0.0109. This proved be safe, confirmed normal levels phenylalanine urea all stages examination children. Conclusions. Short-term background improves hospitalization Larger studies catamnestic observation are needed.

Language: Английский

Associations between sociodemographic characteristics and neonatal length of the stay DOI

Natalie Amodei,

Ellen Nixon,

Shilling Zhang

et al.

Journal of Perinatology, Journal Year: 2024, Volume and Issue: 44(6), P. 851 - 856

Published: May 21, 2024

Language: Английский

Citations

3
Analysis of risk factors and establishment of predictive models for neonatal necrotizing enterocolitis: a retrospective study DOI Creative Commons
Keqin Liu, Jinjin Guo, Yaqi Zhu

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2025, Volume and Issue: 51(1)

Published: March 14, 2025

Abstract Background Necrotizing enterocolitis (NEC) is a leading gastrointestinal condition in preterm infants, characterized by significant morbidity and mortality. Early recognition of risk factors crucial for its prevention prediction. This study focuses on identifying that contribute to the development NEC neonates. Methods A case-control looked back at 144 newborns hospitalized Wuhan hospital between January 2010 March 2023 was carried out. Over same period, another children without were identified selected as non-NEC group comparison, following 1:1 pairing ratio. The relevant data from these two groups compared. Univariate analysis conducted using T-tests or χ 2 tests, followed multivariate logistic regression determine independent develop clinical prediction model. Results total 288 neonates (144 non-NEC) enrolled. variables NEC, shown ( p < 0.05), Small Gestational Age (SGA), neonatal sepsis, hyperbilirubinemia, non-human milk (HM) feeding. Furthermore, ROC (receiver operating characteristic) showed AUC (area under curve) Logistic model predicting effect necrotizing 0.746, suggesting high level discriminative ability differentiating efficacy. can be instrumental facilitating early identification infants prone developing settings. Conclusion In conclusion, associated with newborn include SGA, non-HM Newborn hyperbilirubinemia may potentially serve protective factor against NEC.

Language: Английский

Citations

0
Pregnancy and Birth Outcomes Among Middle Eastern or North African Infants and Mothers in Quebec, Canada, 2008-2020 DOI
Gabriel Côté‐Corriveau,

Nicole Silva-Lavigne,

Méloë Maigné

et al.

Public Health Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Objectives: The health status of Middle Eastern or North African (MENA) populations in Western countries is poorly understood. We assessed whether MENA infants and mothers have a greater risk adverse pregnancy birth outcomes than non-MENA Quebec, Canada. Methods: conducted population-based observational study 809 172 born to pregnant women Quebec from 2008 through 2020. identified the group based on self-reported mother tongue (Arabic Turkish) parents’ country (North country). compared infant maternal outcomes, including gestational diabetes, cesarean delivery, preterm birth, severe neonatal morbidity, other complications between groups. Using log-binomial regression models, we calculated ratios (RRs) 95% CIs measure for with group, adjusting age, comorbidity, patient characteristics. Results: Compared (n = 716 387), 92 785) had an elevated diabetes (RR 1.51; CI, 1.48-1.55), postterm 1.24; 1.08-1.42), short-stay intensive care unit admission 1.91; 1.82-1.99). However, were 15% 50% less likely be preterm, preeclampsia morbidity. Conclusions: Although findings among reassuring overall, may benefit closer perinatal follow-up improve diabetes.

Language: Английский

Citations

0
Time series analysis for forecasting neonatal intensive care unit census and neonatal mortality DOI Creative Commons

Hosein Dalili,

Mamak Shariat,

Leyla Sahebi

et al.

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

Language: Английский

Citations

0
Psychometric Testing of a Scale to Measure Family Resilience Among Parents of Preterm Infants in the NICU DOI Creative Commons
Geneviève Laporte, Céline Gélinas, Christine Genest

et al.

JOGN Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Meaningful clinical outcomes: perspectives of primary caregivers with lived experience of spontaneous preterm birth following spontaneous preterm labor DOI Creative Commons
Elizabeth Gargon, Rosie Sharp, Laura Grant

et al.

American Journal of Obstetrics & Gynecology MFM, Journal Year: 2025, Volume and Issue: unknown, P. 101701 - 101701

Published: May 1, 2025

Language: Английский

Citations

0
Development and validation of a novel risk classification tool for predicting long length of stay in NICU blood transfusion infants DOI Creative Commons

Nurbiya Arkin,

Ting Zhao, Yanqing Yang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 22, 2024

Abstract Newborns are as the primary recipients of blood transfusions. There is a possibility an association between transfusion and unfavorable outcomes. Such complications not only imperil lives newborns but also cause long hospitalization. Our objective to explore predictor variables that may lead extended hospital stays in neonatal intensive care unit (NICU) patients who have undergone transfusions develop predictive nomogram. A retrospective review 539 neonates underwent was conducted using median interquartile ranges describe their length stay (LOS). Neonates with LOS above 75th percentile (P75) were categorized having LOS. The Least Absolute Shrinkage Selection Operator (LASSO) regression method employed screen construct risk model for multiple logistic prediction then constructed selected from LASSO model. significance evaluated by calculating area under ROC curve (AUC) assessing confidence interval around AUC. calibration used further validate model’s predictability. clinical effectiveness assessed through decision analysis. To evaluate generalizability model, fivefold cross-validation employed. Internal validation models performed bootstrap validation. Among infants received transfusions, 398 had (LOS) within normal range 34 days, according range. However, 141 experienced beyond included six variables: gestational age (GA) (< 28 weeks), birth weight (BW) 1000 g), type respiratory support, umbilical venous catheter (UVC), sepsis, resuscitation frequency. receiver operating characteristic (ROC) training set 0.851 (95% CI 0.805–0.891), set, it 0.859 0.789–0.920). Fivefold indicates has good generalization ability. demonstrated strong correlation predicted observed actual risk, indicating consistency. When intervention threshold at 2%, analysis indicated greater utility. results our study led development novel nomogram can assist clinicians predicting probability hospitalization transfused reasonable accuracy. findings indicate GA BW(< UVC, frequency associated higher likelihood among

Language: Английский

Citations

2
Efficacy of short‐course antibiotics for culture‐positive neonatal sepsis: A systematic review and meta‐analysis DOI
Poonam Singh, Mayank Priyadarshi, Suman Chaurasia

et al.

Journal of Paediatrics and Child Health, Journal Year: 2024, Volume and Issue: 60(11), P. 630 - 639

Published: Aug. 16, 2024

Sepsis is a common cause of neonatal mortality and morbidity. Though antibiotics are the mainstay treatment in culture‐positive sepsis, dilemma persists for optimum duration antimicrobial therapy. The present study aimed to evaluate efficacy short‐course uncomplicated sepsis. This systematic review meta‐analysis (PROSPERO: CRD42023444899) identified, appraised, synthesised available evidence from randomised quasi‐randomised controlled trials related (7–10 days) versus standard‐course (14 sepsis on rate failure, mortality, hospitalisation, morbidities including antibiotics‐related adverse events, long‐term neurodevelopmental outcomes cost analysis. Data were pooled using RevMan 5.4 software. Certainty (COE) predefined was analysed by GRADE. Available showed no significant difference failure between 7‐ 10‐day 14‐day courses [risk ratio (95% confidence interval, CI), 2.45 (0.93–6.47), I 2 = 0%, six studies, n 573, very low COE]. No incidence death reported either arm two included studies. Duration hospitalisation significantly shorter with compared [mean −3.88 (−4.22 −3.54) days, five 507, Morbidities three studies similar. Other not reported. To conclude uncertain about effect antibiotic regimen, standard‐course, Adequately powered impairment needed.

Language: Английский

Citations

2
Factors affecting length of stay according to bronchopulmonary dysplasia severity: a nationwide cohort study in Korea DOI Creative Commons

Hye Mi Lee,

Jeongmin Shin, Sae Yun Kim

et al.

World Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 20(5), P. 470 - 480

Published: Feb. 15, 2024

Longer hospitalizations for preterm infants with bronchopulmonary dysplasia (BPD) delay developmental outcomes, increase the risk hospital-acquired complications, and exert a substantial socioeconomic burden. This study aimed to identify factors associated an extended length of stay (LOS) at different levels severity BPD. A cohort was conducted using Korean Neonatal Network registry very low birth weight BPD between 2013 2017 through retrospective analysis. total 4263 were diagnosed For mild BPD, requiring surgical treatment patent ductus arteriosus needed longer LOS [eadjusted β coefficients (adj β) 1.041; 95% confidence interval (CI): 0.01-0.08] hydrocephalus (eadj 1.094; CI 0.01-0.17). In moderate administered steroids or intraventricular hemorrhage required 0.00-0.07 eadj 1.271; 0.11-0.38, respectively). severe comorbidities LOS: pulmonary hypertension 1.174; 0.09-0.23), administrated steroid 1.116; 0.07-0.14), sepsis 1.062; 0.01-0.11), ligation 0.00-0.08), 1.016; 0.05-0.26). Additionally, higher clinical index score, in all groups. The affecting differed according Individualized approaches reducing may be devised knowledge various by severity.

Language: Английский

Citations

1
Colostrum immunotherapy and length of hospital stay in preterm infants: an intervention study DOI Creative Commons
Tatiana de Oliveira Vieira, Camilla da Cruz Martins, Michelle de Santana Xavier Ramos

et al.

Revista Brasileira de Saúde Materno Infantil, Journal Year: 2024, Volume and Issue: 24

Published: Jan. 1, 2024

Abstract Objectives: to evaluate the effect of oropharyngeal colostrum immunotherapy on length hospital stay in preterm newborns with very low birth weight. Methods: interventional ambispective study, which consisted eight daily administrations 0.2 ml (four drops) colostrum, totaling up 56 syringes (for seven days). The control was historic. main independent variable: (days). Survival analysis performed using Kaplan-Meier Method and survival estimated - Log Rank Test (Mantel-Cox) Breslow (Generalized Wilcoxon). A significance level 5% adopted. Results: 109 mother/child pairs, were part treatment 53 group. There no association between for weight general sample. However, after stratification, a shorter (42 versus 51 days, HR= 1.78, CI95%=1.02-3.09, p=0.04) demonstrated among premature infants ≥28 gestational weeks undergoing immunotherapy. Conclusions: we found an median subgroup ≥ 28 age, but did not find significant differences those <28 weeks.

Language: Английский

Citations

1