Probiotic, Prebiotic, and Synbiotic Supplementation for the Prevention and Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis DOI Creative Commons
Freiser Eceomo Cruz Mosquera, Mayerli de la Rosa Caldas, Anisbed Naranjo Rojas

et al.

Children, Journal Year: 2025, Volume and Issue: 12(5), P. 591 - 591

Published: April 30, 2025

Background and Aim: Probiotics, prebiotics, synbiotics have been documented to modulate the microbiota, enhance immunity, reduce antibiotic resistance, making them a promising alternative in management of acute otitis media (AOM). Accordingly, aim this study was determine their effectiveness prevention treatment AOM patients. Methods: A systematic review meta-analysis randomized controlled trials published between 2000 2024 conducted using Science Direct, PubMed, LILACS, SCOPUS, Web Science, Cochrane Clinical Trials, following PRISMA guidelines. The methodological quality evaluated Jadad scale, performed with RevMan 5.4® Jamovi 2.3.28®. Results: total 16 4034 patients were included. showed that intervention did not affect time presentation (MD: −7.98; 95% CI: −19.74 3.78; p = 0.18), recurrence disease (RR: 0.99; 0.74–1.33; 0.96), or requirement for antibiotics 1.31; 0.92 1.84; 0.13); however, it associated reduced probability developing 0.80; 0.66 0.96; 0.02). Subgroup analysis suggests effect probiotic supplementation on incidence is influenced by duration, patient age, number strains product. Conclusions: Supplementation probiotics, significant reduction children, although no impact observed other key clinical parameters. These interventions may be considered as complementary strategy conventional treatments; further high-quality, standardized are needed confirm these findings define optimal protocols.

Language: Английский

Probiotic, Prebiotic, and Synbiotic Supplementation for the Prevention and Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis DOI Creative Commons
Freiser Eceomo Cruz Mosquera, Mayerli de la Rosa Caldas, Anisbed Naranjo Rojas

et al.

Children, Journal Year: 2025, Volume and Issue: 12(5), P. 591 - 591

Published: April 30, 2025

Background and Aim: Probiotics, prebiotics, synbiotics have been documented to modulate the microbiota, enhance immunity, reduce antibiotic resistance, making them a promising alternative in management of acute otitis media (AOM). Accordingly, aim this study was determine their effectiveness prevention treatment AOM patients. Methods: A systematic review meta-analysis randomized controlled trials published between 2000 2024 conducted using Science Direct, PubMed, LILACS, SCOPUS, Web Science, Cochrane Clinical Trials, following PRISMA guidelines. The methodological quality evaluated Jadad scale, performed with RevMan 5.4® Jamovi 2.3.28®. Results: total 16 4034 patients were included. showed that intervention did not affect time presentation (MD: −7.98; 95% CI: −19.74 3.78; p = 0.18), recurrence disease (RR: 0.99; 0.74–1.33; 0.96), or requirement for antibiotics 1.31; 0.92 1.84; 0.13); however, it associated reduced probability developing 0.80; 0.66 0.96; 0.02). Subgroup analysis suggests effect probiotic supplementation on incidence is influenced by duration, patient age, number strains product. Conclusions: Supplementation probiotics, significant reduction children, although no impact observed other key clinical parameters. These interventions may be considered as complementary strategy conventional treatments; further high-quality, standardized are needed confirm these findings define optimal protocols.

Language: Английский

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